PDGFR-β

Platelet-derived growth factor receptor (PDGFR) exists as two closely related receptor tyrosine kinases, PDGFR- α and PDGFR- β. PDGFR consists of five extracellular Ig-like domains involved in ligand binding, a single transmembrane domain, and two intracellular tyrosine kinase domains split by a kinase insert region. Upon ligand binding, PDGFR dimerizes into one of three forms (α/ α, α/ β, or β/ β) in response to the isoform of the PDGF ligand. Dimerization of the receptor results in autophosphorylation of multiple tyrosines (579, 581, 716, 740, 751, 763, 771, 775, 857, 1009, and 1021) in the cytoplasmic domain, recruiting and binding many cytoplasmic signaling and adaptor proteins containing SH2 domains. The PDGF/PDGFR cellular signaling system is essential for the embryonic development of various tissue types and is also important in angiogenesis and wound healing. The characterization of PDGFR overexpression in many solid tumor types and its role in angiogenesis make it an attractive target for anti-cancer therapeutic development.

 

PDGFR-β Singleplex Products

Our PDGFR-β immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of PDGFR-β. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

View All
Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-PDGFR-β -
Browse Our Products

By Analytes
By Applications
Search
Customer Service/Orders


Scientific/Technical Support


Instrument Support


Company Headquarters