OX40L

OX40L (TNFSF4, CD252, gp34, OX40 ligand) is an immune checkpoint protein that is expressed by certain antigen-presenting cells. When OX40L binds to OX40 on cytotoxic T cells it promotes replication and survival of those T cells. When OX40L binds to OX40 on regulatory T cells (Treg) their suppression of cytotoxic T cells is muted resulting in enhanced T-cell activation. OX40L is also expressed by other cell types such as smooth muscle cells and endothelial cells, after specific triggering events. OX40L is also known to suppress apoptosis and is involved in T cell-dependent B-cell proliferation and differentiation.

 

OX40L Singleplex Products

Our OX40L immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of OX40L. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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