Myosin light chain 3 (Myl3) is an essential light chain of the myosin molecule that is found in cardiac and slow-twitch skeletal muscle. Myosin is a hexamer ATPase motor protein and a major constituent of thick muscle filament. It consists of a head domain that “walks” along the actin chain to contract the muscle and a tail domain that is responsible for binding the myosin to its cargo. Two heavy chain subunits intertwine to form the head and tail domains and 4 light chain subunits—2 regulatory light chains with phosphorylation sites (encoded by the MYL2 genes) and 2 essential light chains (encoded by the MYL3 genes)—bind the heavy chains together in the neck region between the head and tail domains. After damage to muscle tissue, myosin breaks down and Myl3 becomes elevated in the blood. Myl3 can be used in conjunction with other toxicity biomarkers to confirm cardiac and slow twitch skeletal muscle injury.


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Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.


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