MMP-3

Matrix metalloprotease-3 (MMP3, SL-1, STMY, STR1, CHDS6, MMP-3, STMY1, stromelysin-1) is a member of the matrix metalloproteinase family of endopeptidases which are critically important in extracellular matrix remodeling. They are highly homologous to each other and belong to a larger family of proteases known as the metzincin superfamily. MMP-3 plays an important role in the degradation and reconstitution of extracellular matrix. MMP-3 is produced as an inactive preform and is proteolytically cleaved to its active form. An important function of MMP-3 is to activate other latent-type MMPs, such as MMP-9, which are originally secreted as proenzymes. Recent studies have implicated MMP-3 in the pathogenesis of Alzheimer’s disease. MMP-3 has also been associated with conditions such as rheumatoid arthritis and cancer cell invasion.

 

MMP-3 Singleplex Products

Our MMP-3 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MMP-3. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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MMP-3 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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