MMP-1

Matrix metalloproteinase-1 (MMP1, CLG, CLGN, interstitial collagenase) is a member of a family of endopeptidases which are critically important in extracellular matrix remodeling. They are highly homologous to each other and belong to a larger family of proteases known as the metzincin superfamily. MMP-1 cleaves collagens of types I, II, III, VII and X. MMP-1 is thought to play an important role in the pathogenesis of rheumatoid arthritis and osteoarthritis by mediating cartilage and bone destruction. MMP-1 has been found to be up-regulated in a variety of cancers and has been suggested to be associated with tumor invasion and metastasis. In addition to collagen, MMP-1 also cleaves a number of non-matrix substrates and probably plays a role in the regulation of cellular behavior.

 

MMP-1 Singleplex Products

Our MMP-1 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MMP-1. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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MMP-1 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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