Macrophage migration inhibitory factor (MIF) is a pleiotropic protein, involved in both innate and adaptive immune responses. MIF was one of the first cytokines discovered through its role in delayed type sensitivity and regulation of macrophage action against bacterial pathogens. MIF is ubiquitously expressed in tissues such as the anterior pituitary, gut and kidney epithelia, skin, and in neuronal and non-neuronal cells of the brain. MIF has been shown to be a key regulator of acute and chronic inflammatory conditions including rheumatoid arthritis, atherosclerosis, and systemic lupus erythematosus. MIF displays a unique regulatory role in its ability to sustain inflammatory responses despite the presence of endogenous or exogenous glucocorticoids. Once released, it “overrides” or counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production. This property makes MIF an attractive therapeutic target for autoimmune and inflammatory diseases.


MIF Singleplex Products

Our MIF immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MIF. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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MIF Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.


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