LBP

Lipopolysaccharide binding protein (LBP) is a protein that was first isolated from acute phase rabbit serum. LBP is constitutively produced by hepatocytes in the liver. It binds to Lipopolysaccharides (LPS) and presents it to the CD14 receptors on monocytic cells. In the presence of LBP, cytokines are released by monocytes at lower concentrations of LPS as compared to that produced in the absence of LBP. Thus, the primary function of LBP is to enhance the ability of the host to detect LPS early in infection. It has been shown that although LBP is required for the induction of inflammatory response, it is not necessary for the clearance of LPS from circulation.

 

LBP Singleplex Products

Our LBP immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of LBP. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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