KC/GRO

KC/GRO is a CXC chemokine also known as CXCL1, GROα, neutrophil-activating protein 3 (NAP-3), and melanoma growth stimulating activity alpha (MGSA-α). KC/GRO is produced by fibroblasts induced by platelet-derived growth factor and expressed in macrophages and endothelial cells. It produces a biological signal by binding to its receptor, CXCR2. During inflammation, it is involved in neutrophil activation, and it shows hematopoietic activity. Upon secretion from bone marrow stromal cells through proteolytic cleavage, the N-terminal processed form of KC (5-72) shows highly enhanced hematopoietic activity. KC/GRO and its receptor are responsible for neutrophil chemotaxis in epidemic keratoconjunctivits.

 

KC/GRO Singleplex Products

Our KC/GRO immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of KC/GRO. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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