IL-31

Interleukin-31 (IL-31) is a four-helix bundle cytokine that belongs to the gp130/IL-6 cytokine family. IL-31 is produced by TH2 cells and signals through a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor. Signaling by IL-31 activates the JAK-STAT, the RAS/ERK, and the PI3K/AKT pathways. IL-31 has been implicated in allergic skin conditions such as atopic dermatitis and has been shown to promote the expression of proinflammatory cytokines in irritable bowel syndrome. IL-31 elevates the expression of EGF, VEGF, and MCP-1, and activates MAPK protein, which induces bronchial inflammation. Due to its active role in inflammation, IL-31 and its receptor are promising therapeutic targets for conditions including atopic dermatitis, airway hypersensitivity, and irritable bowel disease.

 

IL-31 Singleplex Products

Our IL-31 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-31. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-31 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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