IL-18

Interleukin-18 (IL-18) is an 18 kDa cytokine and a co-stimulatory factor that is produced in Kuppfer cells, activated macrophages, keratinocytes, and intestinal epithelial cells. One of the main functions of IL-18 is to promote the production of IFN-γ from T and NK cells, particularly in the presence of IL-12p70. IL-18 also promotes the secretion of other proinflammatory cytokines like TNF-α, IL-1β, and GM-CSF that enhance the migration and activation of neutrophils during microbial infections. In addition, IL-18 enhances cytotoxic activity and proliferation of CD8+ T and NK cells and has been shown to stimulate the production of IL-13 and other Th2 cytokines. Dysregulation of IL-18 may therefore contribute to inflammatory-associated disorders, unchecked infections, autoimmune diseases such as rheumatoid arthritis, acute and chronic kidney injury, cancer, and pathogenic conditions related to metabolic syndrome.

 

IL-18 Singleplex Products

Our IL-18 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of IL-18. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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IL-18 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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