GLP-1 (inactive)

Glucagon-like peptide-1 (GLP-1), a post-translational product of preproglucagon, is a protein hormone produced in intestinal
L cells that plays a key role in the promotion of glucose-dependent insulin secretion and insulin biosynthesis. GLP-1 works in concert with insulin to inhibit glucose secretion and lower overall blood glucose levels. GLP-1 plays roles in gastric emptying upon nutrient intake and in the regulation of short-term feeding behavior. Upon release, it acts through a single G-protein-coupled receptor. GLP-1 receptors are present in several tissues, including pancreatic islets, lung, gastrointestinal tract, and central nervous system. Evidence suggests GLP-1 also can provide beneficial, cyto-protective effects on neuronal cells, skeletal muscle, and the myocardium, elevating its potential role in Alzheimer’s and cardiovascular homeostasis and disease. The cleaved peptides, commonly referred to as GLP-1 (7-36) amide and GLP-1 (7-37) are the biologically active forms of GLP-1. In vivo, these active isoforms are rapidly cleaved by dipeptidyl peptidase IV (DPPIV) to generate the inactive forms. The primary amino acid sequence for GLP-1 is conserved among mammalian species, i.e., human, mouse, rat, monkey, canine, etc. GLP-1 (inactive) consists of the 9-36 and smaller fragments of the GLP-1 peptide forms.

 

GLP-1 (inactive) Singleplex Products

Our GLP-1 (inactive) immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of GLP-1 (inactive). MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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GLP-1 (inactive) Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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