GITR

Glucocorticoid-Induced TNFR-Related protein (GITR, TNFRSF18, AITR, CD357) is an immune checkpoint, cell surface receptor expressed on T-cells, and its expression increases when the T cells are activated. GITR binds GITRL (AITRL), a cytokine that is secreted by endothelial cells. Knockout studies in mice suggest that GITR helps regulate CD3-driven T-cell activation and programmed cell death. The soluble form of GITR is elevated in cancer.

 

GITR Singleplex Products

Our GITR immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of GITR. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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