ErbB2

ErbB2 (HER-2/Neu) belongs to a family of four type I receptor-tyrosine kinases structurally consisting of an ectodomain, a single transmembrane segment, and a cytoplasmic region that includes a protein tyrosine kinase domain. ErbB2 currently does not have any known direct ligand but becomes activated through overexpression or heterodimerization with other members of the ErbB family. Activation of ErbB2 results in the autophosphorylation of several tyrosines (including 1248) on the intracellular domain of the receptor. This tyrosine phosphorylation links ErbB2 with several intracellular signaling pathways—including the PI-3 kinase, ERK, and p38 pathways—through proteins such as Ras, Grb2, and Shc. ErbB2 activation exerts an effect on a variety of cellular processes including development, apoptosis, and transformation, proliferation and survival. Overexpression of ErbB2 has been detected in several types of human cancers including breast, ovarian, and prostate, and its overexpression alone, as well as coupled with p53 accumulation and the cytoplasmic location of p21, is correlated with a poor breast cancer patient prognosis. ErbB2 is a major target of anti-cancer drugs, with the ectodomain-directed antibody Herceptin currently approved for breast cancer treatment.

 

ErbB2 Singleplex Products

Our ErbB2 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of ErbB2. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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ErbB2 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-ErbB2 -
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