Troponin T (cardiac)

Cardiac Troponin T (TNNT2, TnTC, cTnT) is one protein of a heterotrimer (along with Troponins C and I) that regulates muscle contraction in skeletal and cardiac muscle. Troponin acts with intracellular calcium to control the interaction of actin and myosin filaments in striated muscle fibers. Though they perform similar functions, cardiac and skeletal troponins differ in sequence and can be differentiated in immunoassays. Troponin T interacts with tropomyosin to form the troponin-tropomyosin complex. Troponin I is an inhibitory subunit that prevents muscle contraction in the absence of calcium. It is responsible for the binding of the troponin-tropomyosin complex to actin. Troponin I exists in three isoforms: slow-twitch (striated) skeletal muscle, fast-twitch (striated) skeletal muscle, and cardiac. Troponin C binds calcium, producing a conformational change in troponin I and activating the troponin-tropomyosin complex. When muscle tissue is damaged, the troponin-tropomyosin complex breaks down, and troponin I and troponin T are released into the blood. Troponin T (cardiac) and troponin I (cardiac) can be readily distinguished from their skeletal muscle analogs, allowing confirmation of cardiac muscle tissue damage over skeletal muscle tissue damage. Troponins are generally considered excellent biomarkers for myocardial injury in cardiotoxicity research because of the demonstrated tissue specificity of cardiac and skeletal troponins.

 

Troponin T (cardiac) Singleplex Products

Our Troponin T (cardiac) immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Troponin T (cardiac). MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Troponin T (cardiac) Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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