BDNF

Brain-Derived Neurotrophic Factor (BDNF, ANON2, BULN2) is part of the nerve growth factor family. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. The protein is active in the hippocampus, cortex, and basal forebrain, areas vital to learning, memory, and higher thinking, and is important for long-term memory. BDNF is neuroprotective in neurodegenerative conditions, peripheral nerve injury, and stroke. BDNF interacts with the tropomyosin receptor kinase B (TrkB) and p75 neurotrophin receptors, thereby eliciting its biological effects. BDNF is biologically active as a homodimer. BDNF monomers are 122-amino-acid in length and have three intramolecular disulfide bonds in a cysteine knot configuration. Due to the intricate folding and assembly of BDNF, there is low heterologous productivity of the protein. BDNF has been associated with brain trauma and neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and schizophrenia.

 

BDNF Singleplex Products

Our BDNF immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of BDNF. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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BDNF Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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