Ang-1

Angiopoietin 1 (AGP1, AGPT, ANG1, ANGPT1) is a growth factor that belongs to the Angiopoietin family of proteins. Four different angiopoietins have been identified: Ang-1, Ang-2, Ang-3, and Ang-4. Angiopoietins play a crucial role in the modulation, maturation, and maintenance of the vascular and lymphatic systems. Despite their often opposing regulatory roles in angiogenesis, both Ang-1 and Ang-2 are ligands for the endothelial cell receptor tyrosine kinase, Tie-2. Angiopoietin/Tie-2 signaling promotes angiogenesis during the development, remodeling, and repair of the vascular system. These interactions are complex and often mediated by the local cytokine and growth factor microenvironment. Ang-1 and Ang-2 are essential for the formation of mature blood vessels and have been implicated in several human cancers, in tumor angiogenesis, growth, and progression.

 

Ang-1 Singleplex Products

Our Ang-1 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Ang-1. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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