Serpin A1

Serpin A1 (PI, A1A, AAT, PI1, PRO2275, α1AT, α-1-anti-trypsin) is the major serine protease inhibitor of the serpin superfamily. Serpin A1 is primarily produced in and secreted by the liver and inhibits a wide variety of proteases including trypsin and neutrophil elastase, as well as bacterial proteases. The concentration of serpin A1 in plasma can rise significantly in acute inflammation. It's absence is associated with lung-related diseases including chronic obstructive pulmonary disease (COPD) and emphysema. It has been hypothesized that the inhibition of serine proteinases by serpin A1 may play a role in the suppression of cancer cell growth due to the prevention of the proteolytic release of membrane-bound transforming growth factor-α. Differentially sialylated forms of serpin A1 have been associated with dementia caused during Alzheimer's disease and Parkinson's disease.

 

Serpin A1 Singleplex Products

Our Serpin A1 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Serpin A1. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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