V-PLEX Plus Human IL-1β Kit


Human interleukin-1β (IL-1β), also known as IL-1F2, is a 30.7 kDa pro-inflammatory cytokine that is produced by activated macrophages. IL-1β stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. Along with IL-1α, IL-1β binds directly to IL-1 RI, which is then associated with IL-1 R accessory protein (IL-1RAcP) to form a high-affinity receptor complex for signal transduction. IL-1β is involved in a number of biological activities ranging from aging to wound healing. Along with IFN-γ, IL-6, and TNF-α, IL-1β is a pyrogenic cytokine that induces the production of prostaglandins, the major mediators of fever induction. The Human IL-1β Kit provides the assay-specific components for the quantitative determination of endogenous IL-1β in human urine, serum, plasma, and cell culture supernatants.

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25 plates
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