R-PLEX Human Granzyme B Antibody Set Overview
The R-PLEX Human Granzyme B Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of Granzyme B in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX and U-PLEX analytes, can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products
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R-PLEX Human Granzyme B Antibody Set Features
- Measures human Granzyme B in serum, plasma, and cell lysate
- Dynamic range: 0.30-2,000 pg/mL
- Median LLOD: 0.30 pg/mL
- Can be used to develop individual analyte assays as well as multiplex panels
Typical Data
Calibration curve for the R-PLEX Human Granzyme B Antibody Set was assessed and representative data is presented below.
Figure 1. R-PLEX Human Granzyme B Antibody Set Calibration Curve
Granzyme B Analyte
Description - Granzyme B (GZMB, C11, CTLA-1, CTSGL1, SECT) is a protease found in secretory granules of cytotoxic T cells and NK cells. When secreted into the target cell, Granzyme B causes cell death by activating many of the caspase enzymes present inside cells. Granzyme B has other functions including stimulating the release of proinflammatory cytokines and remodeling of extracellular matrices. It may also play a role in the development of chronic obstructive pulmonary disease and hair loss.
Disease Research Area - Infectious Diseases
Application Area - Immunology/Inflammation, Immuno-Oncology
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Recommended Components
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Specifications
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Kit Contents
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References
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Documentation
Why do I need other components
Catalog No.
Product Name
Size
R51BB-4
R50AA-4
R92TG-3
L45SA-1
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Application(s)
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Immunology/Inflammation
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Immunogenicity
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Analyte(s)
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Granzyme B
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Species
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Human
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Goat Polyclonal
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LLOD (Sensitivity)
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0.30 pg/mL
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Dynamic Range
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0.30-2,000 pg/mL
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Sample Type
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Serum, Plasma, Cell Lysate
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Gene ID(s)
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3002
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UniProt ID(s)
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P10144
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Assay Diluent(s)
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Diluent 2
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Antibody Diluent(s)
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Diluent 3
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Product Description
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Storage
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Quantity per Kit
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Human Granzyme B Antibody Set
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2-8°C
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1 each
(5 plate size)
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Human Granzyme B Calibrator
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≤-70°C
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5 vial
(1 vial)
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Product Description
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Storage
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Quantity per Kit
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Human Granzyme B Antibody Set
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2-8°C
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10 each
(5 plate size)
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Human Granzyme B Calibrator
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≤-70°C
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50 vial
(1 vial)
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Title
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Journal
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Year
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Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics
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Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial
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Product Inserts
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Datasheets
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Handouts
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SDS
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Order Details
Catalog No
Size
Price in USD
Qty
Customer Service/Orders
Scientific/Technical Support
Instrument Support
Company Headquarters