R-PLEX Human Granzyme A Antibody Set

R-PLEX Human Granzyme A Antibody Set Overview
The R-PLEX Human Granzyme A Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of Granzyme A in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX and U-PLEX analytes, can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products click here.

R-PLEX Human Granzyme A Antibody Set Features
  • Measures human Granzyme A in serum, plasma, and cell lysate
  • Dynamic range: 1.4-2,000 pg/mL
  • Median LLOD: 1.4 pg/mL
  • Can be used to develop individual analyte assays as well as multiplex panels

Typical Data
Calibration curve for the R-PLEX Human Granzyme A Antibody Set was assessed and representative data is presented below.

Figure 1. R-PLEX Human Granzyme A Antibody Set Calibration Curve
Calibration Curve for R-PLEX Human Granzyme A Antibody Set
Granzyme A Analyte

Description - Granzyme A (GZMA, CTLA3, CTL tryptase) is a protease found in abundant quantities in secretory granules of cytotoxic T cells and NK cells. When secreted into the target cell via the immunological synapse, Granzyme A causes cell death by cleaving various proteins including those in the mitochondria and in the nucleosome which then degrade the DNA. This protease has been found to be elevated in infectious diseases or an otherwise pro-inflammatory state.

Disease Research Area - Infectious Diseases, Oncology

Application Area - Immunology/Inflammation, Immuno-Oncology

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5 plate size
50 plate size
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