R-PLEX Human GITR Antibody Set

R-PLEX Human GITR Antibody Set Overview
The R-PLEX Human GITR Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of GITR in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX and U-PLEX analytes, can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products click here.

R-PLEX Human GITR Antibody Set Features
  • Measures human GITR in serum, plasma, and cell lysate
  • Dynamic range: 0.52-10,000 pg/mL
  • Median LLOD: 0.52 pg/mL
  • Can be used to develop individual analyte assays as well as multiplex panels

Typical Data
Calibration curve for the R-PLEX Human GITR Antibody Set was assessed and representative data is presented below.

Figure 1. R-PLEX Human GITR Antibody Set Calibration Curve
Calibration Curve for R-PLEX Human GITR Antibody Set
GITR Analyte

Description - Glucocorticoid-Induced TNFR-Related protein (GITR, TNFRSF18, AITR, CD357) is an immune checkpoint, cell surface receptor expressed on T cells, and its expression increases when the T cells are activated. GITR binds GITRL (AITRL), a cytokine that is secreted by endothelial cells. Knockout studies in mice suggest that GITR helps regulate CD3-driven T cell activation and programmed cell death. The soluble form of GITR is elevated in cancer.

Disease Research Area - Autoimmune & Inflammation

Application Area - Immunology/Inflammation, Immuno-Oncology

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5 plate size
50 plate size
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