R-PLEX Human CTLA-4 Antibody Set

R-PLEX Human CTLA-4 Antibody Set Overview
The R-PLEX Human CTLA-4 Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of CTLA-4 in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX and U-PLEX analytes, can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products click here.

R-PLEX Human CTLA-4 Antibody Set Features
  • Measures human CTLA-4 in serum, plasma, and cell lysate
  • Dynamic range: 12-15,000 pg/mL
  • Median LLOD: 12 pg/mL
  • Can be used to develop individual analyte assays as well as multiplex panels

Typical Data
Calibration curve for the R-PLEX Human CTLA-4 Antibody Set was assessed and representative data is presented below.

Figure 1. R-PLEX Human CTLA-4 Antibody Set Calibration Curve
Calibration Curve for R-PLEX Human CTLA-4 Antibody Set
CTLA-4 Analyte

Description - Cytotoxic T-lymphocyte associated protein 4 (CTLA-4, ALPS5, CD152) is a protein receptor that acts as an immune checkpoint and can transmit an inhibitory signal to T cells when bound to CD80 or CD86. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Blocking CTLA-4 and CD80/86 interaction augments antitumor T-cell activity. Mutations in this gene have been associated with many autoimmune diseases.

Disease Research Area - Autoimmune & Inflammation

Application Area - Immunology/Inflammation, Immuno-Oncology

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5 plate size
50 plate size
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