Click image to enlarge
C-Kit is a member of a subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3/flk-2 receptors. Studies have shown that c-Kit plays a critical role in the activation and growth of a number of cell types including hematopoietic stem cells, mast cells, melanocytes, and germ cells. Mutations in c-Kit have been associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, and acute myeloid leukemia. Antibodies to c-Kit are widely used in immunohistochemistry to distinguish between different types of tumors in histological tissue sections. MSD’s Phospho/Total c-Kit uses a traditional immuno-sandwich format to accurately measure total and phosphorylated levels of human c-Kit in cellular lysates and whole cells, and is compatible with many cell types. This kit provides the assay-specific components for the quantitative determination of phosphorylated c-Kit in human serum and plasma samples.
-
-
Specifications
-
-
Documentation
-
References
Product Inserts
|
|
|
Datasheets
|
|
|
SDS
|
|
|
Title
|
Journal
|
Year
|
|
Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse.
|
|
|
|
Placental Growth Factor and Soluble c-Kit Receptor Dynamics Characterize the Cytokine Signature of Imatinib in Prostate Cancer and Bone Metastases.
|
|
|
|
Placental growth factor and soluble c-kit receptor dynamics characterize the cytokine signature of imatinib in prostate cancer and bone metastases.
|
|
|
|
Phase 1 study of the investigational, oral angiogenesis inhibitor motesanib in Japanese patients with advanced solid tumors.
|
|
|
|
|
Customer Service/Orders
Scientific/Technical Support
Instrument Support
Company Headquarters