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Tau is a microtubule-associated protein with multiple splice forms found primarily in neurons. Hyperphosphorylated tau is the major component of paired helical filaments and other large intracellular aggregates in the brains of patients with Alzheimer's disease and some other neurodegenerative disorders. The Phospho(Thr231)/Total Tau Base Kit provides basic components for the quantitative determination of phospho-tau (Thr231) and total tau in human and mouse brain homogenates and tissue culture supernatants. Base kits generally include only MSD plates coated with the capture antibody, SULFO-TAG-labeled antibody, and MSD proprietary read buffer. (See product insert for a list of kit components). Base kits are most commonly used for high-throughput screening and assay development.
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Specifications
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Documentation
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References
Application(s)
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Alzheimer’s Disease
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Phosphoproteins
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Neurobiology/Neurodegeneration
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Intracellular Signaling
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Analyte(s)
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Tau (total)
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Species
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Human, Mouse
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Instrument(s)
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SECTOR Imager 2400
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SECTOR Imager 6000
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MESO QuickPlex SQ 120
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MESO QuickPlex SQ 120MM
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MESO SECTOR S 600
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MESO SECTOR S 600MM
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Plate Type
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96-well
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LLOD (Sensitivity)
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Phospho-Tau: 0.09 units Total Tau: 0.05 ng/mL
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Dynamic Range
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Phospho-Tau: 0.09-50 units Total Tau: 0.05-1000 ng/mL
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Kit Model
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Base
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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2-8 °C
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Product Inserts
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Datasheets
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SDS
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Title
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Journal
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Year
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Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment
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Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein.
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High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.
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Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models.
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The AD-CSF-Index discriminates Alzheimer's disease patients from healthy controls: A validation study
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