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Aβ (Abeta or beta-amyloid) is formed after sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. γSecretase, which produces the C-terminal end of the Aβ peptide, cleaves APP to generate a number of isoforms of 36-43 amino acids in length. Aβ42 functions as a cell surface receptor on neurons, controlling neuronal growth, adhesion, and axonogenesis. Aβ42 is also a major component of amyloid plaques and accumulates in the neurons of Alzheimer’s disease brains. Both tau and Aβ42 have been identified as core biomarkers of Alzheimer’s disease. Their levels in cerebrospinal fluid (CSF) reproducibly distinguished normal and Alzheimer’s patients, and in combination, they may be useful in identifying patients with mild cognitive impairment (MCI) or other types of neurodegenerative dementia. The Human Aβ42 Kit has been validated for the quantitative determination of Aβ42 protein in human CSF. This validated assay uses an Aβ42-specific capture antibody with the n-terminal, anti-beta amyloid (1-16) antibody (6E10 clone) as the detection antibody. The 6E10 clone is provided by Covance Research Products, Inc.