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The Inflammation Panel 1 (rat) Kit provides assay-specific components for the quantitative determination of lipocalin-2, thrombospondin 1 (TSP-1), tissue inhibitor of metalloproteinases (TIMP-1), and monocyte chemoattractant protein-1 (MCP-1) in rat serum and plasma.
Increased levels of proinflammatory cytokines play a pivotal role in the pathogenesis of inflammatory diseases such as atherosclerosis, rheumatoid arthritis, and acute and chronic kidney injury. TIMP-1 and lipocalin-2 expression is indicative of inflammatory action following infection, ischemia, and endotoxic insults to the endothelium and stromal matrix. TSP-1, a key activator of TGF-β1, mediates wound healing, cell proliferation, and extracellular matrix formation at sites of injury and bleeding. TSP-1, secreted in response to inflammation, promotes the resolution of the inflammatory process and facilitates phagocytosis or apoptosis of damaged cells, protecting tissues from excessive damage. MCP-1 is uniformly upregulated at sites of vascular disease or injury and is one of the earliest cellular responses to atherogenesis.
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Specifications
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Kit Contents
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Documentation
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References
Application(s)
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Cytokines & Chemokines
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Cardiac Injury
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Toxicology
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Kidney Injury
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Immunology/Inflammation
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Analyte(s)
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MCP-1, NGAL/LCN2, TIMP-1, TSP-1
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Species
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Rat
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
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MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
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MESO SECTOR S 600
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Plate Type
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96-well
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Condition
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Multi-Component
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Schedule B Code
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3002.15.0100
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Product Description
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Storage
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Quantity per Kit
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Inflammation Panel 1 (rat) Calibrator Blend
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≤-70 °C
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1 vial (20 μL)
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SULFO-TAG Anti-rat MCP-1 Antibody
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2-8 °C
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1 vial (75 μL)
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SULFO-TAG Anti-rat TSP-1 Antibody
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2-8 °C
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1 vial (75 μL)
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SULFO-TAG Anti-rat Lipocalin-2 Antibody
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2-8 °C
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1 vial (75 μL)
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SULFO-TAG Anti-rat TIMP-1 Antibody
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2-8 °C
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1 vial (75 μL)
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Inflammation Panel 1 (rat) Plate
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2-8 °C
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1 each (1 each)
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2-8 °C
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1 bottle (50 mL)
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≤-10 °C
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1 bottle (5 mL)
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RT
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1 bottle (50 mL)
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Product Description
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Storage
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Quantity per Kit
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Inflammation Panel 1 (rat) Calibrator Blend
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≤-70 °C
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5 vial (20 μL)
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SULFO-TAG Anti-rat MCP-1 Antibody
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2-8 °C
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1 vial (375 μL)
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SULFO-TAG Anti-rat TSP-1 Antibody
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2-8 °C
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1 vial (375 μL)
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SULFO-TAG Anti-rat Lipocalin-2 Antibody
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2-8 °C
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1 vial (375 μL)
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SULFO-TAG Anti-rat TIMP-1 Antibody
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2-8 °C
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1 vial (375 μL)
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Inflammation Panel 1 (rat) Plate
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2-8 °C
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5 each (1 each)
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2-8 °C
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2 bottle (200 mL)
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≤-10 °C
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1 bottle (50 mL)
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RT
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1 bottle (50 mL)
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Product Description
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Storage
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Quantity per Kit
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Inflammation Panel 1 (rat) Calibrator Blend
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≤-70 °C
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25 vial (20 μL)
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SULFO-TAG Anti-rat MCP-1 Antibody
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2-8 °C
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5 vial (375 μL)
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SULFO-TAG Anti-rat TSP-1 Antibody
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2-8 °C
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5 vial (375 μL)
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SULFO-TAG Anti-rat Lipocalin-2 Antibody
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2-8 °C
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5 vial (375 μL)
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SULFO-TAG Anti-rat TIMP-1 Antibody
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2-8 °C
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5 vial (375 μL)
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Inflammation Panel 1 (rat) Plate
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2-8 °C
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25 each (1 each)
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2-8 °C
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10 bottle (200 mL)
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≤-10 °C
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5 bottle (50 mL)
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RT
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5 bottle (50 mL)
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Product Inserts
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Datasheets
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Certificate of analysis
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SDS
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Title
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Journal
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Year
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Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection
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Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
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Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial
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CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer’s disease
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Kinetics and Biomarkers of Severe Cytokine Release Syndrome after CD19 Chimeric Antigen Receptor-modified T Cell Therapy.
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