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The Cardiac Injury Panel 3 (rat) Kit provides assay-specific components for the quantitative determination of both natural and recombinant rat cardiac troponin I (cTnI), cardiac troponin T (cTnT), fatty acid binding protein 3 (FABP3), and myosin light chain 3 (Myl3) in serum and plasma.
Troponin is a heterodimer that regulates muscle contraction in skeletal and cardiac muscle. Troponin acts with intracellular calcium to control the interaction of actin and myosin filaments in striated muscle fibers. When muscle tissue is damaged, the troponin-tropomyosin complex breaks down and troponin I and troponin T are released into the blood. cTnI and cTnT can be readily distinguished from their skeletal muscle making them excellent biomarkers for myocardial injury and cardiotoxicity. FABP3 is a monomeric protein that modulates the uptake of fatty acids in cells. Heart-type fatty acid binding protein is released into circulation after myocardial ischemia and necrosis. FABP3 is mostly present in heart and skeletal muscle but can also be found in brain, liver, and small intestine. Myl3 is an essential light chain of the myosin molecule found in cardiac and slow-twitch skeletal muscle. After damage to muscle tissue, myosin breaks down and Myl3 becomes elevated in the blood. Myl3 can be used in conjunction with other toxicity biomarkers to confirm cardiac and slow twitch skeletal muscle injury.