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IGF (Insulin like Growth Factor) signaling is mediated by the ligands IGF1 and IGF2, and the receptors IGF-1R (Insulin like Growth Factor-1 Receptor), IGF-2R, and IR (Insulin Receptor). Additionally, downstream signaling from IGF-1R/IR through the PI3K signaling pathway is accomplished due to the adaptor protein IRS-1 (Insulin Receptor Substrate-1) binding to the phosphorylated and activated IGF-1R or IR. IR and IGF-1R signaling play a key role in normal development, growth, metabolism, and cellular homeostasis as well as being implicated in such disease processes as growth abnormalities, metabolic processes, and different types of cancer. Pharmacological disruption of IGF-1R/IR signaling is a fertile area of research, but due a critical role in normal cellular metabolism and growth, the ability to identify selective therapeutics targeting abnormally signaling cells would be greatly advantageous. This kit provides the basic components for the quantitative determination of phospho-IGF-1R, phospho-IR, and phospho-IRS-1 in human whole cell lysates.
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Specifications
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Documentation
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References
Application(s)
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Phosphoproteins
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Intracellular Signaling
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Analyte(s)
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IGF-1R, IgG, IR, IRS-1
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
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SECTOR Imager 6000
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MESO QuickPlex SQ 120
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MESO QuickPlex SQ 120MM
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MESO SECTOR S 600
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MESO SECTOR S 600MM
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Plate Type
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96-well
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Capture Antibody
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Phospho-IGF-1R: Mouse MonoclonalPhospho-IR: Mouse MonoclonalPhospho-IRS-1: Mouse Monoclonal
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Detection Antibody
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Phospho-IGF-1R: Mouse MonoclonalPhospho-IR: Mouse MonoclonalPhospho-IRS-1: Mouse Monoclonal
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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2-8 °C
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Product Inserts
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Datasheets
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SDS
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Title
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Journal
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Year
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Age-Associated Seroprevalence of Coronavirus Antibodies: Population-Based Serosurveys in 2013 and 2020, British Columbia, Canada
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IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare Workers
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MSD-based assays facilitate a rapid and quantitative serostatus profiling for the presence of anti-AAV antibodies
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Clinical Performance of Three Commercial and Two In-House Multiplex Assays for SARS-CoV-2 Antibody Detection in Dried Blood Spot Specimens
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SARS-CoV-2 Nucleocapsid Plasma Antigen for Diagnosis and Monitoring of COVID-19
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