The Effect of Leflunomide on Cycling and Activation of T-Cells in HIV-1-Infected Participants.

Register
Cart (0)

Home > References > 2010 > The Effect of Leflunomide on Cycling and Activation of T-Cells in HIV-1-Infected Participants.

Contact an Account Manager

The Effect of Leflunomide on Cycling and Activation of T-Cells in HIV-1-Infected Participants.

Read, S.W., DeGrezia, M., Ciccone, E.J., DerSimonian, R., Higgins, J., Adelsberger, J.W., Starling, J.M., Rehm, C., Sereti, I.

Journal		PLoS ONE
Species
Analytes Measured		CRP
Matrix Tested		Plasma

Year		2010
Volume		5
Page Numbers
Application		Cytokines and Chemokines

Abstract

Background: The pathogenesis of immunodeficiency due to human immunodeficiency virus (HIV)-1 is incompletely understood, but immune activation is believed to play a central role. Immunomodulatory agents that decrease immune activation may be useful in the treatment of HIV-1 infection.

Methodology: A randomized, double blind, placebo-controlled pilot study of leflunomide for 28 days was performed in participants with HIV-1 infection who were not receiving antiretroviral therapy. Participants randomized to leflunomide were subsequently treated with cholestyramine until leflunomide levels were below detection limit.

Findings: Treatment with leflunomide was well tolerated with mostly low-grade adverse events. Leflunomide administration reduced cycling of CD4 T cells (by ex vivo bromodeoxyuridine uptake and Ki67 expression) and decreased expression of activation markers (HLA-DR/CD38 co-expression) on CD8 T cells in peripheral blood. In addition, decreased expression of HIV-1 co-receptors was observed in both CD4 and CD8 T cells in the leflunomide group. There were no significant changes in naïve and memory T cell subsets, apoptosis of T cells or markers of microbial translocation.

Conclusions: Leflunomide was effective in reducing immune activation in the setting of chronic HIV-1 infection suggesting that targeting immune activation with immunomodulatory agents may be a feasible strategy.

View Publications

Related Products


U-PLEX Custom Biomarker Group 3 (human) Assays A2M, Adiponectin, ApoA1, ApoC3, CA1, Clusterin, Complement C9, Complement factor D, CRP, Cystatin C, DPPIV, Factor VII, ICAM-1, NGAL/LCN2, RBP4, SAA, Serpin A1, SHBG, sTfR-1, VCAM-1, vWF \| Human Multiplex
U-PLEX Metabolic Combo 2 (human) Adiponectin, ApoA1, ApoC3, Clusterin, CRP, DPPIV, NGAL/LCN2, RBP4, SHBG, sTfR-1 \| Human Multiplex
U-PLEX Inflammation Combo 1 (human) Complement C9, Complement factor D, CRP, ICAM-1, NGAL/LCN2, SAA, VCAM-1 \| Human Multiplex
U-PLEX Vascular Injury Combo 1 (human) CRP, Factor VII, ICAM-1, SAA, VCAM-1 \| Human Multiplex
U-PLEX Custom Biomarker Group 3 (hu) 384-well Assays A2M, Adiponectin, ApoA1, ApoC3, CA1, Clusterin, Complement C9, Complement factor D, CRP, Cystatin C, DPPIV, Factor VII, ICAM-1, NGAL/LCN2, RBP4, SAA, Serpin A1, SHBG, sTfR-1, VCAM-1, vWF \| Human Multiplex
U-PLEX Human CRP 384-Well Assay CRP \| Human Singleplex
U-PLEX Human CRP Assay CRP \| Human Singleplex
U-PLEX Human CRP Antibody Set CRP \| Human
R-PLEX Mouse CRP Antibody Set CRP \| Mouse
R-PLEX Mouse CRP Assay CRP \| Mouse Singleplex
V-PLEX Human Biomarker 39-Plex Kit CRP, Eotaxin, Eotaxin-3, FGF (basic), GM-CSF, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Plus Human Biomarker 39-Plex Kit CRP, Eotaxin, Eotaxin-3, FGF (basic), GM-CSF, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Plus Neuroinflammation Panel 1 Human Kit CRP, Eotaxin, Eotaxin-3, FGF (basic), ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Neuroinflammation Panel 1 Human Kit CRP, Eotaxin, Eotaxin-3, FGF (basic), ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Human CRP Kit CRP \| Human Singleplex
V-PLEX Plus Human CRP Kit CRP \| Human Singleplex
V-PLEX Plus Vascular Injury Panel 2 Human Kit CRP, ICAM-1, SAA, VCAM-1 \| Human Multiplex
V-PLEX Vascular Injury Panel 2 Human Kit CRP, ICAM-1, SAA, VCAM-1 \| Human Multiplex
Human CRP Antibody CRP
Vascular Injury Control Pack 1 CRP, ICAM-1, SAA, VCAM-1 \| Human

R-PLEX: Matched Antibody Sets - Suitable for Many Research Applications

Quick Links

Browse Our Products

By Analytes

By Applications

Contact Information

Customer Service/Orders
1-240-314-2795

5:00 a.m. to 8:00 p.m.
US Eastern Time

Email

Scientific/Technical Support
1-240-314-2798

8:30 a.m. to 5:30 p.m.
US Eastern Time

Email

Instrument Support
1-301-947-2057

8:30 a.m. - 5:30 p.m.
US Eastern Time

Email

Company Headquarters
1-240-314-2600
1601 Research Blvd.
Rockville, Maryland 20850-3173
USA


U-PLEX Custom Biomarker Group 3 (human) Assays A2M, Adiponectin, ApoA1, ApoC3, CA1, Clusterin, Complement C9, Complement factor D, CRP, Cystatin C, DPPIV, Factor VII, ICAM-1, NGAL/LCN2, RBP4, SAA, Serpin A1, SHBG, sTfR-1, VCAM-1, vWF \| Human Multiplex
U-PLEX Metabolic Combo 2 (human) Adiponectin, ApoA1, ApoC3, Clusterin, CRP, DPPIV, NGAL/LCN2, RBP4, SHBG, sTfR-1 \| Human Multiplex
U-PLEX Inflammation Combo 1 (human) Complement C9, Complement factor D, CRP, ICAM-1, NGAL/LCN2, SAA, VCAM-1 \| Human Multiplex
U-PLEX Vascular Injury Combo 1 (human) CRP, Factor VII, ICAM-1, SAA, VCAM-1 \| Human Multiplex
U-PLEX Custom Biomarker Group 3 (hu) 384-well Assays A2M, Adiponectin, ApoA1, ApoC3, CA1, Clusterin, Complement C9, Complement factor D, CRP, Cystatin C, DPPIV, Factor VII, ICAM-1, NGAL/LCN2, RBP4, SAA, Serpin A1, SHBG, sTfR-1, VCAM-1, vWF \| Human Multiplex
U-PLEX Human CRP 384-Well Assay CRP \| Human Singleplex
U-PLEX Human CRP Assay CRP \| Human Singleplex
U-PLEX Human CRP Antibody Set CRP \| Human
R-PLEX Mouse CRP Antibody Set CRP \| Mouse
R-PLEX Mouse CRP Assay CRP \| Mouse Singleplex
V-PLEX Human Biomarker 39-Plex Kit CRP, Eotaxin, Eotaxin-3, FGF (basic), GM-CSF, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Plus Human Biomarker 39-Plex Kit CRP, Eotaxin, Eotaxin-3, FGF (basic), GM-CSF, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Plus Neuroinflammation Panel 1 Human Kit CRP, Eotaxin, Eotaxin-3, FGF (basic), ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Neuroinflammation Panel 1 Human Kit CRP, Eotaxin, Eotaxin-3, FGF (basic), ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Human CRP Kit CRP \| Human Singleplex
V-PLEX Plus Human CRP Kit CRP \| Human Singleplex
V-PLEX Plus Vascular Injury Panel 2 Human Kit CRP, ICAM-1, SAA, VCAM-1 \| Human Multiplex
V-PLEX Vascular Injury Panel 2 Human Kit CRP, ICAM-1, SAA, VCAM-1 \| Human Multiplex
Human CRP Antibody CRP
Vascular Injury Control Pack 1 CRP, ICAM-1, SAA, VCAM-1 \| Human

Please Sign In

User name

Password

The Effect of Leflunomide on Cycling and Activation of T-Cells in HIV-1-Infected Participants.

Abstract

Related Products

Quick Links

Browse Our Products

Contact Information

Products

Services

Orders & Support

Key Topics