The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691).

Fidock, M.D., Souberbielle, B.E., Laxton, C., Rawal, J., Delpuech-Adams, O., Corey, T.P., Colman, P., Kumar, V., Cheng, J.B., Wright, K., Srinivasan, S., Rana, K., Craig, C., Horscroft, N., Perros, M., Westby, M., Webster, R., van der Ryst, E.
Journal   Clin Pharmacol Ther.
Species  
Analytes Measured   IL-6 , IP-10
Matrix Tested   Serum
Year   2011
Volume   89
Page Numbers   821-829
Application   Cytokines and Chemokines
Abstract
Hepatitis C virus (HCV) infection is an issue of global concern, and studies are ongoing to identify new therapies that are both effective and safe. PF-4878691 is a Toll-like receptor 7 (TLR7) agonist modeled so as to dissociate its antiviral activities from its inflammatory activities. In a proof-of-mechanism study in healthy volunteers who received doses of 3, 6, and 9 mg of PF-4878691 twice a week for 2 weeks, PF-4878691 induced biomarkers of the immune and interferon (IFN) responses in a dose-dependent and dose-frequency-related manner. A novel finding was induction of TLR7 expression in vivo in response to PF-4878691, leading to an amplified biomarker response. A nonresponder at the 9-mg dose had a polymorphism in the IFN-α receptor 1 subunit (Val168Leu). Two subjects who had received 9-mg doses experienced serious adverse events (SAEs), characterized by flu-like symptoms, hypotension, and lymphopenia, leading to early termination of the study. TLR7 stimulation results in a pharmacologic response at levels commensurate with predicted antiviral efficacy, but these doses are associated with SAEs, raising concerns about the therapeutic window of this class of compounds for the treatment of HCV infection.

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IP-10 | Mouse
Singleplex
U-PLEX NHP IL-6 Assay
IL-6 | Non-human primate
Singleplex
U-PLEX NHP IP-10 Assay
IP-10 | Non-human primate
Singleplex
R-PLEX Rat IL-6 Assay
IL-6 | Rat
Singleplex
R-PLEX Rat IL-6 Antibody Set
IL-6 | Rat
V-PLEX Cytokine Panel 1 Mouse Kit
IL-9, IL-15, IL-17A/F, IL-27p28/IL-30, IL-33, IP-10, MCP-1, MIP-1α, MIP-2 | Mouse
Multiplex
V-PLEX Plus Cytokine Panel 1 Mouse Kit
IL-9, IL-15, IL-17A/F, IL-27p28/IL-30, IL-33, IP-10, MCP-1, MIP-1α, MIP-2 | Mouse
Multiplex
V-PLEX Plus Mouse Cytokine 19-Plex Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-17A/F, IL-27p28/IL-30, IL-33, IP-10, KC/GRO, MCP-1, MIP-1α, MIP-2, TNF-α | Mouse
Multiplex
V-PLEX Mouse Cytokine 19-Plex Kit
IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-17A/F, IL-27p28/IL-30, IL-33, IP-10, KC/GRO, MCP-1, MIP-1α, MIP-2, TNF-α | Mouse
Multiplex
Cytokine Panel 1 Mouse Control Pack
IL-9, IL-15, IL-17A/F, IL-27p28/IL-30, IL-33, IP-10, MCP-1, MIP-1α, MIP-2 | Mouse
V-PLEX Plus Mouse IP-10 Kit
IP-10 | Mouse
Singleplex
V-PLEX Mouse IP-10 Kit
IP-10 | Mouse
Singleplex
U-PLEX Mouse IP-10 Antibody Set
IP-10 | Mouse
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