Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.

Caskey M, Lefebvre F, Filali-Mouhim A, Cameron MJ, Goulet JP, Haddad EK, Breton G, Trumpfheller C, Pollak S, Shimeliovich I, Duque-Alarcon A, Pan L, Nelkenbaum A, Salazar AM, Schlesinger SJ, Steinman RM, Sékaly RP.
Journal   J Exp Med.
Species  
Analytes Measured   GM-CSF , IL-10 , IL-12 p70 , IL-2 , IL-6 , IL-8
Matrix Tested   Plasma
Year   2011
Volume   208
Page Numbers   2357-2366
Application   Cytokines and Chemokines , Immunogenicity
Abstract
Adjuvants are critical for the success of vaccines. Agonists of microbial pattern recognition receptors (PRRs) are promising new adjuvant candidates. A mechanism through which adjuvants enhance immune responses is to stimulate innate immunity. We studied the innate immune response in humans to synthetic double-stranded RNA (polyinosinic:polycytidylic acid [poly IC] stabilized with poly-L-lysine [poly ICLC]), an agonist for toll-like receptor (TLR) 3, and the cytosolic RNA helicase MDA-5. Transcriptional analysis of blood samples from eight volunteers, after subcutaneous administration of poly ICLC, showed up-regulation of genes involved in multiple innate immune pathways in all subjects, including interferon (IFN) and inflammasome signaling. Blocking type I IFN receptor ex vivo significantly dampened the response to poly IC. Comparative transcriptional analysis showed that several innate immune pathways were similarly induced in volunteers immunized with the highly efficacious yellow fever vaccine. Therefore, a chemically defined PRR agonist like poly ICLC can be a reliable and authentic microbial mimic for inducing innate immune responses in humans.

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Singleplex
U-PLEX Mouse IL-6 384-Well Assay
IL-6 | Mouse
Singleplex
U-PLEX Mouse IL-10 384-Well Assay
IL-10 | Mouse
Singleplex
U-PLEX Mouse IL-12p70 384-Well Assay
IL-12p70 | Mouse
Singleplex
U-PLEX NHP GM-CSF 384-Well Assay
GM-CSF | Non-human primate
Singleplex
U-PLEX NHP IL-2 384-Well Assay
IL-2 | Non-human primate
Singleplex
U-PLEX NHP IL-6 384-Well Assay
IL-6 | Non-human primate
Singleplex
U-PLEX NHP IL-8 384-Well Assay
IL-8 | Non-human primate
Singleplex
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