Search For Scientific Publications - Meso Scale Discovery

Research laboratories and drug development companies around the world use MSD technology to analyze disease states through the characterization and quantification of biomarkers. We maintain a list of scientific journal articles that describe how MSD assays have been instrumental in providing highly sensitive, quantified, reproducible results.

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Title	Journal	Year
NEW! Assessment of DBS technology for the detection of therapeutic antibodies. Prince PJ, Matsuda KC, Retter M, Scott G.	Bioanalysis. 2010 Aug;2(8):1449-60.	2010
Identification of an HIV-1 Clade A Envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting 3 distinct epitopes. Hoffenberg S, Powell R, Carpov A, Wagner D, Wilson A, Kosakovsky Pond S, Lindsay R, Arendt H, Destefano J, Phogat S, Poignard P, Fling SP, Simek M, Labranche C, Montefiori D, Wrin T, Phung P, Burton D, Koff W, King CR, Parks CL, Caulfield MJ.	J Virol	2013
A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma. Voorhees PM, Manges RF, Sonneveld P, Jagannath S, Somlo G, Krishnan A, Lentzsch S, Frank RC, Zweegman S, Wijermans PW, Orlowski RZ, Kranenburg B, Hall B, Casneuf T, Qin X, van de Velde H, Xie H, Thomas SK.	Br J Haematol	2013
Pharmacology of AMG 181, a human anti-α(4) β(7) antibody that specifically alters trafficking of gut-homing T cells. Pan WJ, Hsu H, Rees WA, Lear SP, Lee F, Foltz IN, Rathanaswami P, Manchulenko K, Chan BM, Zhang M, Xia XZ, Patel SK, Prince PJ, Doherty DR, Sheckler CM, Reynhardt KO, Krill CD, Harder BJ, Wisler JA, Brandvig JL, Lynch JL, Anderson AA, Wienkers C, Borie C.	Br J Pharmacol	2013
Phase I study of Ofatumumab, a human anti-CD20 antibody, in Japanese patients with relapsed or refractory chronic lymphocytic leukemia and small lymphocytic lymphoma. Ogura M, Hatake K, Tobinai K, Uchida T, Suzuki T, Terui Y, Yokoyama M, Maruyama D, Mori M, Jewell RC, Katsura K, Hotta T.	Jpn J Clin Oncol	2013
Controlled human infection and re-challenge with Streptococcus Pneumoniae reveals the protective efficacy of carriage in healthy adults. Ferreira DM, Neill DR, Bangert M, Gritzfeld JF, Green N, Wright AK, Pennington SH, Moreno LB, Moreno AT, Miyaji EN, Wright AD, Collins AM, Goldblatt D, Kadioglu A, Gordon SB.	Am J Respir Crit Care Med	2013
Adults 65 years old and older have reduced numbers of functional memory T cells to respiratory syncytial virus fusion protein. Cherukuri A, Patton K, Gasser RA Jr, Zuo F, Woo J, Esser MT, Tang RS.	Clin Vaccine Immunol.	2013
Pre- and postnatal development in the cynomolgus monkey following administration of ABT-874, a human anti-IL-12/23p40 monoclonal antibody. Enright BP, Tornesi B, Weinbauer GF, Blaich G.	Birth Defects Res B Dev Reprod Toxicol	2012
Male and female fertility assessment in the cynomolgus monkey following administration of ABT-874, a human anti-IL-12/23p40 monoclonal antibody. Enright BP, Tornesi B, Weinbauer GF, Blaich G.	Birth Defects Res B Dev Reprod Toxicol	2012
GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus: a first-in-humans randomized clinical study. Curtin F, Lang AB, Perron H, Laumonier M, Vidal V, Porchet HC, Hartung HP.	Clin Ther	2012
Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA; CARE-MS II investigators.	Lancet.	2012
Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Cohen JA, Coles AJ, Arnold DL, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Fisher E, Brinar VV, Giovannoni G, Stojanovic M, Ertik BI, Lake SL, Margolin DH, Panzara MA, Compston DA; CARE-MS I investigators.	Lancet.	2012
Correlation of screening and confirmatory results in tiered immunogenicity testing by solution-phase bridging assays Kubiak RJ, Zhang L, Zhang J, Zhu Y, Lee N, Weichold FF, Yand H, Abraham V, Akufongwe PF, Hewitt L, Robinson S, Liu W, Liu X, Patnaik MM, Spitz S, Wu Y, Roskos LK.	Journal of Pharmaceutical and Biomedical Analysis	2012
Immunogenicity, safety and efficacy of abatacept administered subcutaneously with or without background methotrexate in patients with rheumatoid arthritis: Results from accompany, a phase III study. Nash P, Nayiager S, Genovese MC, Kivitz AJ, Oelke K, Ludivico C, Palmer W, Rodriguez C, Delaet I, Elegbe A, Corbo M.	Arthritis Care Res.	2012
Pharmacokinetic and pharmacodynamic comparability study of moxetumomab pasudotox, an immunotoxin targeting CD22, in cynomolgus monkeys. Wang B, Liang M, Yao Z, Vainshtein I, Lee R, Schneider A, Zusmanovich M, Jin F, O'Connor K, Donato-Weinstein B, Iciek L, Lavallee T, Roskos L.	J Pharm Sci.	2012
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Axup JY, Bajjuri KM, Ritland M, Hutchins BM, Kim CH, Kazane SA, Halder R, Forsyth JS, Santidrian AF, Stafin K, Lu Y, Tran H, Seller AJ, Biroc SL, Szydlik A, Pinkstaff JK, Tian F, Sinha SC, Felding-Habermann B, Smider VV, Schultz PG.	Proc Natl Acad Sci U S A.	2012
Overcoming soluble target interference in an anti-therapeutic antibody screening assay for an antibody-drug conjugate therapeutic. Carrasco-Triguero M, Mahood C, Milojic-Blair M, Amaya C, Ruppel J, Hong K, Yi JH, Kaur S.	Bioanalysis.	2012
A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer. Hudes G, Tagawa ST, Whang YE, Qi M, Qin X, Puchalski TA, Reddy M, Cornfeld M, Eisenberger M.	Invest New Drugs.	2012
Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging. Kamath AV, Williams SP, Bullens S, Cowan KJ, Stenberg Y, Cherry SR, Rendig S, Kukis DL, Griesemer C, Damico-Beyer LA, Bunting S.	PLoS One	2012
Evaluation of a new serological technique for detecting rabies virus antibodies following vaccination. Ma X, Niezgoda M, Blanton JD, Recuenco S, Rupprecht CE.	Vaccine.	2012
Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors. Murakami H, Doi T, Yamamoto N, Watanabe J, Boku N, Fuse N, Yoshino T, Ohtsu A, Otani S, Shibayama K, Takubo T, Loh E.	Cancer Chemother Pharmacol.	2012
Development and evaluation of a multiplex enzyme-linked immunosorbent assay for the detection of antibodies to bovine respiratory diseases on the Meso Scale Discovery platform. Mayers J, Sawyer J.	J Vet Diagn Invest.	2012
Human B-cell ontogeny in humanized NOD/SCID γc(null) mice generates a diverse yet auto/poly- and HIV-1-reactive antibody repertoire. Chang H, Biswas S, Tallarico AS, Sarkis PT, Geng S, Panditrao MM, Zhu Q, Marasco WA.	Genes Immun.	2012
Epitope characterization of pre-existing and developing antibodies to an aglycosylated monoclonal antibody therapeutic of G1m17,1 allotype. Tatarewicz SM, Juan G, Swanson SJ, Moxness MS.	J Immunol Methods.	2012
Embryo-fetal distribution of a biopharmaceutical IgG2 during rat organogenesis. Bowman CJ, King LE, Stedman DB.	Reprod Toxicol.	2012

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