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Human Total Tau Kit
Tau has emerged as a putative therapeutic target for many neurodegenerative disorders. Tau and several hyperphosphorylated forms of this protein are major components of paired helical filaments and other large intracellular aggregates in the brains of patients with Alzheimer's disease and other neurodegenerative disorders such as frontotemporal dementia, Pick’s disease, and related tauopathies. Tau and Aβ42 have been identified as core biomarkers of Alzheimer’s disease. Their levels in cerebrospinal fluid (CSF) reproducibly distinguished normal and Alzheimer’s patients, and in combination, they may be useful in identifying patients with mild cognitive impairment (MCI) or other types of neurodegenerative dementia. The Human Total Tau Kit is a validated assay for the quantitative determination of total tau protein, including its six isoforms (352 to 441 amino acids), in human CSF.

Product Detail
Application Alzheimer's Markers
Analyte Tau
Species Human
Instrument SI2400, SI6000
Plate Type 96-well singleplex
 
Product Type Validated
Documents
Title Lot Number
doc Data sheet
doc Product insert
doc Certificate of analysis K0040113
doc Control Pack
doc Scientific poster
doc Certificate of analysis K0040144
Product Options
Catalog No. Product Name Size
K151LAE-4 Human Total Tau Kit 25 plates
K151LAE-2 Human Total Tau Kit 5 plates
Additional Information
Related Publications Journal Year  
Long-term stability of Alzheimer's disease biomarker proteins in cerebrospinal fluid.
Schipke, C.G., Jessen, F., Teipel, S., Luckhaus, C., Wiltfang, J., Esselmann, H., Frölich, L., Maier, W., Rüther, E., Heppner, F.L., Prokop, S., Heuser, I., Peters, O. 		J Alzheimers Dis. 2011
Identification of SPARC-like Protein as Part of a Biomarker Panel for Alzheimer's Disease in Cerebrospinal Fluid.
Vafadar-Isfahani, B., Ball, G., Coveney, C., Lemetre, C., Boocock, D., Minthon, L., Hansson, O., Miles, A.K., Janciauskiene, S.M., Warden, D., Smith, A.D., Wilcock, G., Kalsheker, N., Rees, R., Matharoo-Ball, B., Morgan, K. 		J Alzheimers Dis. 2011
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S.D., Bernardini, S., et al. 		Alzheimers Dement. 2011
Comparison of immunosorbent assays for the quantification of biomarkers for Alzheimer's disease in human cerebrospinal fluid.
Schipke, C.G., Prokop, S., Heppner, F.L., Heuser, I., Peters, O. 		Dement Geriatr Cogn Disord. 2011
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. 		Nature. 2012

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Price and Availability
Price Please call for price
Size 1 plate
Catalog No. K151LAE-1
Availability Usually ships in 1-3 days

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Phone: 1-301-947-2085
FAX: 1-301-990-2776
Email: customerservice@mesoscale.com
Request a Catalog Quote
Contact a Sales Representative

Support
Phone: 1-301-947-2025
Email: scientificsupport@mesoscale.com
Contact Scientific Support
Request a Certificate of Analysis
Related Publications Journal Year  
Long-term stability of Alzheimer's disease biomarker proteins in cerebrospinal fluid.
Schipke, C.G., Jessen, F., Teipel, S., Luckhaus, C., Wiltfang, J., Esselmann, H., Frölich, L., Maier, W., Rüther, E., Heppner, F.L., Prokop, S., Heuser, I., Peters, O. 		J Alzheimers Dis. 2011
Identification of SPARC-like Protein as Part of a Biomarker Panel for Alzheimer's Disease in Cerebrospinal Fluid.
Vafadar-Isfahani, B., Ball, G., Coveney, C., Lemetre, C., Boocock, D., Minthon, L., Hansson, O., Miles, A.K., Janciauskiene, S.M., Warden, D., Smith, A.D., Wilcock, G., Kalsheker, N., Rees, R., Matharoo-Ball, B., Morgan, K. 		J Alzheimers Dis. 2011
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S.D., Bernardini, S., et al. 		Alzheimers Dement. 2011
Comparison of immunosorbent assays for the quantification of biomarkers for Alzheimer's disease in human cerebrospinal fluid.
Schipke, C.G., Prokop, S., Heppner, F.L., Heuser, I., Peters, O. 		Dement Geriatr Cogn Disord. 2011
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.
Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. 		Nature. 2012
Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer's Disease Drug Candidates.
Löffler T, Flunkert S, Taub N, Schofield EL, Ward MA, Windisch M, Hutter-Paier B. 		J Mol Neurosci. 2012



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