Search For Scientific Publications - Meso Scale Discovery

Research laboratories and drug development companies around the world use MSD technology to analyze disease states through the characterization and quantification of biomarkers. We maintain a list of scientific journal articles that describe how MSD assays have been instrumental in providing highly sensitive, quantified, reproducible results.

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Title	Journal	Year
Idiopathic normal-pressure hydrocephalus: Pathophysiology and diagnosis by CSF biomarkers. Jeppsson A, Zetterberg H, Blennow K, Wikkelso C.	Neurology	2013
Cerebrospinal fluid Aβ levels correlate with structural brain changes in Parkinson's disease. Beyer MK, Alves G, Hwang KS, Babakchanian S, Bronnick KS, Chou YY, Dalaker TO, Kurz MW, Larsen JP, Somme JH, Thompson PM, Tysnes OB, Apostolova LG.	Mov Disord	2013
Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS. Ash PE, Bieniek KF, Gendron TF, Caulfield T, Lin WL, Dejesus-Hernandez M, van Blitterswijk MM, Jansen-West K, Paul JW 3rd, Rademakers R, Boylan KB, Dickson DW, Petrucelli L.	Neuron	2013
Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice. Walker JR, Pacoma R, Watson J, Ou W, Alves J, Mason DE, Peters EC, Urbina HD, Welzel G, Althage A, Liu B, Tuntland T, Jacobson LH, Harris JL, Schumacher AM.	J Neurosci	2013
IFN-γ production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease. Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA.	J Immunol	2013
SAR investigations on a novel class of gamma-secretase modulators based on a unique scaffold Austin WF, Hubbs JL, Fuller NO, Creaser SP, McKee TD, Loureiro RMB, Findeis MA, Tate B, Ives JL, Bronk BS.	Med Chem Comm	2013
New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ.	Alzheimers Dement	2013
Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C.	J Neurosci. 2012 Dec 12;32(50):18204-14.	2012
Modulation of gamma-secretase for the treatment of Alzheimer's disease. Tate B, McKee TD, Loureiro RM, Dumin JA, Xia W, Pojasek K, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS.	Int J Alzheimers Dis.	2012
Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer's disease. Johansson P, Almqvist EG, Johansson JO, Mattsson N, Hansson O, Wallin A, Blennow K, Zetterberg H, Svensson J.	Psychoneuroendocrinology	2012
The role of γ-Secretase Activating Protein, GSAP and imatinib in the regulation of γ-secretase activity and amyloid-β generation. Hussain I, Fabregue J, Anderes L, Ousson S, Borlat F, Eligert V, Berger S, Dimitrov M, Alattia JR, Fraering PC, Beher D.	J Biol Chem.	2012
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Vom Berg J, Prokop S, Miller KR, Obst J, Kälin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL.	Nat Med.	2012
PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/Presenilin 1 mice. Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, Heneka MT.	Journal of Neuroscience	2012
Hyperhomocysteinemia in Alzheimer's disease: The hen and the egg? Farkas M, Keskitalo S, Smith DE, Bain N, Semmler A, Ineichen B, Smulders Y, Blom H, Kulic L, Linnebank M.	J Alzheimers Dis.	2012
First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. Borgegard T, Juréus A, Olsson F, Rosqvist S, Sabirsh A, Rotticci D, Paulsen K, Klintenberg R, Yan H, Waldman M, Stromberg K, Nord J, Johansson J, Regner A, Parpal S, Malinowsky D, Radesater AC, Li T, Singh R, Eriksson H, Lundkvist J.	J Biol Chem.	2012
Neuroinflammatory phenotype in early Alzheimer's disease. Sudduth TL, Schmitt FA, Nelson PT, Wilcock DM.	Neurobiol Aging.	2012
Effects of single doses of Avagacestat (BMS-708163) on cerebrospinal fluid Aβ levels in healthy young men. Tong G, Castaneda L, Wang JS, Sverdlov O, Huang SP, Slemmon R, Gu H, Wong O, Li H, Berman RM, Smith C, Albright C, Dockens RC.	Clin Drug Investig.	2012
Open-heart surgery increases cerebrospinal fluid levels of Alzheimer-associated amyloid β. Reinsfelt B, Westerlind A, Blennow K, Zetterberg H, Ricksten SE.	Acta Anaesthesiol Scand.	2012
A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of Avagacestat (BMS-708163) in healthy young and elderly subjects. Dockens R, Wang JS, Castaneda L, Sverdlov O, Huang SP, Slemmon R, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Tong G.	Clin Pharmacokinet.	2012
Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL.	Development.	2012
Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines. Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF.	Neurobiol Dis.	2012
Mass spectrometric characterization of Amyloid-β species in the 7PA2 cell model of Alzheimer's disease. Portelius E, Olsson M, Brinkmalm G, Rüetschi U, Mattsson N, Andreasson U, Gobom J, Brinkmalm A, Hölttä M, Blennow K, Zetterberg H.	J Alzheimers Dis.	2012
Amyloid-β metabolism in Niemann-Pick C disease models and patients. Mattsson N, Olsson M, Gustavsson MK, Kosicek M, Malnar M, Månsson JE, Blomqvist M, Gobom J, Andreasson U, Brinkmalm G, Vite C, Hecimovic S, Hastings C, Blennow K, Zetterberg H, Portelius E.	Metab Brain Dis.	2012
Role of genes linked to sporadic Alzheimer's disease risk in the production of β-amyloid peptides. Bali J, Gheinani AH, Zurbriggen S, Rajendran L.	Proc Natl Acad Sci U S A.	2012
Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. Wanngren J, Ottervald J, Parpal S, Portelius E, Strömberg K, Borgegård T, Klintenberg R, Juréus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlström H.	J Biol Chem.	2012

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