Search For Scientific Publications - Meso Scale Discovery

Research laboratories and drug development companies around the world use MSD technology to analyze disease states through the characterization and quantification of biomarkers. We maintain a list of scientific journal articles that describe how MSD assays have been instrumental in providing highly sensitive, quantified, reproducible results.

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Title	Journal	Year
Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit. Wang J, Vanegas SM, Du X, Noble T, Zingg JM, Meydani M, Meydani SN, Wu D.	Nutr Metab (Lond)	2013
Glycemic, insulinemic, and appetite responses of patients with type 2 diabetes to commonly consumed breads. Breen C, Ryan M, Gibney MJ, Corrigan M, O'Shea D.	Diabetes Educ	2013
Consumption of buckwheat modulates the post-prandial response of selected gastrointestinal satiety hormones in individuals with type 2 diabetes mellitus. Stringer DM, Taylor CG, Appah P, Blewett H, Zahradka P.	Metabolism	2013
Quinine controls body weight gain without affecting food intake in male C57BL6 mice. Cettour-Rose P, Bezençon C, Darimont C, le Coutre J, Damak S.	BMC Physiol	2013
Fibroblast growth factor 21 mediates specific glucagon actions. Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, et al.	Diabetes	2013
Diacylglycerol Acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release. Lin HV, Chen D, Shen Z, Zhu L, Ouyang X, Vongs A, Kan Y, Levorse JM, Kowalik EJ Jr, Szeto DM, Yao X, Xiao J, Chen S, Liu J, Garcia-Calvo M, Shin MK, Pinto S.	PLoS One	2013
Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance. Samokhvalov V, Ussher JR, Fillmore N, Armstrong IK, Keung W, Moroz D, Lopaschuk DG, Seubert J, Lopaschuk GD.	Am J Physiol Endocrinol Metab	2012
Cognitive functions in middle aged individuals are related to metabolic disturbances and aerobic capacity: a cross-sectional study Pedersen M, Pedersen KK, Bruunsgaard H, Krabbe KS, Thomsen C, Færch K, Pedersen BK, Mortensen EL.	PLoS One.	2012
Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release – potential insight into mechanism of action. Liu J, Gorski J, Gold SJ, Chen D, Chen S, Forrest G, Itoh Y, Marsh D, McLaren D, Shen Z, Sonatore L, Carballo-Jane E, Craw S, Guan X, Karanam B, Sakaki J, Szeto D, Tong X, Xiao J, Yoshimoto R, Yu H, Balkovec J, Pinto S.	Obesity	2012
The DPP-4 inhibitor Linagliptin counteracts stroke in the normal and diabetic mouse brain: a comparison with Glimepiride. Darsalia V, Ortsater H, Olverling A, Darlöf E, Wolbert P, Nystrom T, Klein T, Sjoholm A, Patrone C.	Diabetes	2012
Effect of Sitagliptin on post-prandial glucagon and GLP-1 levels in patients with type 1 diabetes: Investigator-initiated, double-blind, randomized, placebo-controlled trial. Garg SK, Moser EG, Bode B, Klaff L, Hiatt WR, Beatson C, Snell-Bergeon JK.	Endocr Pract	2012
Transcriptional factor regulatory factor X 6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high-fat diet-induced obesity. Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N.	J Biol Chem.	2012
Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes Hecht R, Li Y, Sun J, Belouski E, Hall M, Hager T, Yie J, Wang W, Winters D, Smith S, Spahr C, Tam L, Shen Z, Stanislaus S, Chinookoswong N, Lau Y, Sickmier A, Michaels ML, Boone T, Veniant MM, Xu J.	PLoS One	2012
Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice. Irwin N, Montgomery IA, Moffett RC, Flatt PR.	Biochem Pharmacol.	2012
The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis. Shao W, Wang D, Chiang YT, Ip W, Zhu L, Xu F, Columbus J, Belsham DD, Irwin DM, Zhang H, Wen X, Wang Q, Jin T.	Diabetes.	2012
Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells. Poreba MA, Dong CX, Li SK, Stahl A, Miner JH, Brubaker PL.	Am J Physiol Endocrinol Metab.	2012
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, Ofrecio J, Lin M, Brenner MB, Olefsky JM.	Nat Med.	2012
A novel high-sensitivity electrochemiluminescence (ECL) sandwich immunoassay for the specific quantitative measurement of plasma glucagon. Sloan JH, Siegel RW, Ivanova-Cox YT, Watson DE, Deeg MA, Konrad RJ.	Clin Biochem.	2012
Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. Nieman DC, Gillitt N, Jin F, Henson DA, Kennerly K, Shanely RA, Ore B, Su M, Schwartz S.	J Altern Complement Med.	2012
Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals. Schauble CL, Hampel R, Breitner S, Rückerl R, Phipps R, Diaz-Sanchez D, Devlin RB, Carter JD, Soukup J, Silbajoris R, Dailey L, Koenig W, Cyrys J, Geruschkat U, Belcredi P, Kraus U, Peters A, Schneider AE.	Occup Environ Med.	2012
Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes. Irwin N, Frizelle P, Montgomery IA, Moffett RC, O'Harte FP, Flatt PR.	Diabetologia.	2012
The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice. Vollert S, Kaessner N, Heuser A, Hanauer G, Dieckmann A, Knaack D, Kley HP, Beume R, Weiss-Haljiti C.	Diabetologia.	2012
GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis. Kim S, Nian C, Karunakaran S, Clee SM, Isales CM, McIntosh CHS.	PLoS One	2012
Choline deficiency attenuates body weight gain and improves glucose tolerance in ob/ob mice. Wu G, Zhang L, Li T, Lopaschuk G, Vance DE, Jacobs RL.	J Obes.	2012
Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine. Klein T, Niessen HG, Ittrich C, Mayoux E, Mueller HP, Cheetham S, Stiller D, Kassubek J, Mark M.	Diabetes Obes Metab.	2012

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