Search For Scientific Publications - Meso Scale Discovery

Research laboratories and drug development companies around the world use MSD technology to analyze disease states through the characterization and quantification of biomarkers. We maintain a list of scientific journal articles that describe how MSD assays have been instrumental in providing highly sensitive, quantified, reproducible results.

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Title	Journal	Year
Assessment of cisplatin-induced kidney injury using an integrated rodent platform. Chen Y, Brott D, Luo W, Gangl E, Kamendi H, Barthlow H, Lengel D, Fikes J, Kinter L, Valentin JP, Bialecki R.	Toxicol Appl Pharmacol	2013
Irreversible renal damage after transient Renin-Angiotensin System stimulation: involvement of an AT1-receptor mediated immune response. Heijnen BF, Nelissen J, van Essen H, Fazzi GE, Cohen Tervaert JW, Peutz-Kootstra CJ, Mullins JJ, Schalkwijk CG, Janssen BJ, Struijker-Boudier HA.	PLoS One	2013
A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats. Sun CC, Vaja V, Chen S, Theurl I, Stepanek A, Brown DE, Cappellini MD, Weiss G, Hong CC, Lin HY, Babitt JL.	Nephrol Dial Transplant	2013
Underestimation of urinary biomarker-to-creatinine ratio resulting from age-related gain in muscle mass in rats. Tonomura Y, Morikawa Y, Takagi S, Torii M, Matsubara M.	Toxicology	2012
Renal biomarker changes associated with hyaline droplet nephropathy in rats are time and potentially compound dependent. Brott DA, Bentley P, Nadella MV, Thurman D, Fikes J, Cheatham L, McGrath F, Luo W, Kinter LB.	Toxicology	2012
Evaluation of miR-122 and other biomarkers in distinct acute liver injury in rats Starckx S, Batheja A, Verheyen GR, Jonghe SD, Steemans K, Dijck BV, Singer M, Bogdan N, Snoeys J, Vinken P, Sasaki JC, Gompel JV, Guzzie-Peck P, Lampo A, Lammens L.	Toxicol Pathol.	2012
Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media. Rouse RL, Stewart SR, Thompson KL, Zhang J.	Toxicol Pathol.	2012
Adora2b Adenosine Receptor Signaling Protects during Acute Kidney Injury via Inhibition of Neutrophil-Dependent TNF-α Release. Grenz A, Kim JH, Bauerle JD, Tak E, Eltzschig HK, Clambey ET.	J Immunol.	2012
Controlled regulation of erythropoietin by primary cultured renal cells for renal failure induced anemia. Gyabaah K, Aboushwareb T, Guimaraes Souza N, Yamaleyeva L, Varner A, Wang HJ, Atala A, Yoo JJ.	J Urol.	2012
Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats. Thompson KL, Zhang J, Stewart S, Rosenzweig BA, Shea K, Mans D, Colatsky T.	Toxicol Lett.	2012
Evaluation of novel renal biomarkers with a cisplatin model of kidney injury: gender and dosage differences. Pinches M, Betts C, Bickerton S, Burdett L, Thomas H, Derbyshire N, Jones HB, Moores M.	Toxicol Pathol.	2012
Urine Biomarkers Predict Acute Kidney Injury in Newborns. Askenazi DJ, Koralkar R, Hundley HE, Montesanti A, Parwar P, Sonjara S, Ambalavanan N.	J Pediatr.	2012
Evaluation of novel urinary renal biomarkers: biological variation and reference change values. Pinches MD, Betts CJ, Bickerton SJ, Beattie L, Burdett LD, Thomas HT, Derbyshire NA, Moores M, Price SA.	Toxicol Pathol.	2012
Comparison of the Diagnostic Accuracy of Di-22:6-Bis(monoacylglycerol)Phosphate and Other Urinary Phospholipids for Drug-Induced Phospholipidosis or Tissue Injury in the Rat. Thompson KL, Haskins K, Rosenzweig BA, Stewart S, Zhang J, Peters D, Knapton A, Rouse R, Mans D, Colatsky T.	Int J Toxicol.	2012
(2011) Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury. Swain, A., Turton, J., Scudamore, C., Maguire, D., Pereira, I., Freitas, S., Smyth, R., Munday, M., Stamp, C., Gandhi, M., Sondh, S., Ashall, H., Francis, I., Woodfine, J., Bowles, J., York, M.	J Appl Toxicol.	2011
Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension. Zhou, X., Crook, M.F., Sharif-Rodriguez, W., Zhu, Y., Ruben, Z., Pan, Y., Urosevic-Price, O., Wang, L., Flattery, A.M., Forrest, G., Szeto, D., Zhao, H., Roy, S., Forrest, M.J.	Clin Exp Hypertens.	2011
Comparison of the course of biomarker changes and kidney injury in a rat model of drug-induced acute kidney injury. Sasaki, D., Yamada, A., Umeno, H., Kurihara, H., Nakatsuji, S., Fujihira, S., Tsubota, K., Ono, M., Moriguchi, A., Watanabe, K., Seki, J.	Biomarkers.	2011
Antisense oligonucleotide suppression of serum amyloid A reduces amyloid deposition in mice with AA amyloidosis. Kluve-Beckerman, B., Hardwick, J., Du, L., Benson, M.D., Monia, B.P., Watt, A., Crooke, R.M., Mullick, A.	Amyloid.	2011
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. Sugimoto, H., Okada, K., Shoda, J., Warabi, E., Ishige, K., Ueda, T., Taguchi, K., Yanagawa, T., Nakahara, A., Hyodo, I., Ishii, T., Yamamoto, M.	Am J Physiol Gastrointest Liver Physiol.	2010
Recommendations to qualify biomarker candidates of drug-induced liver injury. Ozer, J.S., Chetty, R., Kenna, G., Koppiker, N., Karamjeet, P., Li, D., Palandra, J., Lanevschi, A., Souberbielle, B.E., Ramaiah, S.	Biomark Med.	2010
Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats. Rouse, R.L., Zhang, J., Stewart, S.R., Rosenzweig, B.A., Espandiari, P., Sadrieh, N.K.	Kidney Int.	2010
Application of Dolichos biflorus in immunoassay detection of kidney collecting duct biomarkers. Sourial, S., Searchfield, L., Schuppe-Koistinen, I., Betton, G.R., Riccardi, D., Price, S.A.	Biomarkers.	2010
Applications of a planar electrochemiluminescence platform to support regulated studies of macromolecules: Benefits and limitations in assay range. Thway, T., Macaraeg, C., Calamba, D., Patel, V., Tsoi, J., Ma, M., Lee, J., Desilva, B.	Pharm Biomed Anal.	2010
Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats. Tonomura, Y., Tsuchiya, N., Torii, M., Uehara, T.	Toxicology.	2010
Hypoxia-inducible factor 1{alpha} (HIF-1 {alpha}) and autophagy in polycystic kidney disease (PKD). Belibi, F., Zafar, I., Ravichandran, K., Bauer Segvic, A., Jani, A., Ljubanovic, D.G., Edelstein, C.L.	Am J Physiol Renal Physiol.	2011

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