Search For Scientific Publications - Meso Scale Discovery

Research laboratories and drug development companies around the world use MSD technology to analyze disease states through the characterization and quantification of biomarkers. We maintain a list of scientific journal articles that describe how MSD assays have been instrumental in providing highly sensitive, quantified, reproducible results.

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Title	Journal	Year
Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function. Gordon CJ, Jarema KA, Lehmann JR, Ledbetter AD, Schladweiler MC, Schmid JE, Ward WO, Kodavanti UP, Nyska A, MacPhail RC.	Inhal Toxicol	2013
Elevated remnant lipoproteins may increase subclinical CVD risk in pre-pubertal children with obesity: a case-control study. Wang Y, Pendlebury C, Dodd MM, Maximova K, Vine DF, Jetha MM, Ball GD, Proctor SD.	Pediatr Obes.	2012
Analytical performance validation of a coronary heart disease risk assessment multi-analyte proteomic test Nolan N, Tee L, Vijayakumar S, Burazor I, Hytopoulos E, Biggs WH, Beggs M, French C, Harrington DS.	Expert Opin Med Diagn	2012
Safety, tolerability, pharmacokinetics, and pharmacodynamics of Losmapimod following a single intravenous or oral dose in healthy volunteers. Barbour AM, Sarov-Blat L, Cai G, Fossler MJ, Sprecher DL, Graggaber J, McGeoch AT, Maison J, Cheriyan J.	Br J Clin Pharmacol.	2012
Fibromodulin deficiency reduces low-density lipoprotein accumulation in atherosclerotic plaques in apolipoprotein E-null mice. Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J, Oldberg A, Hultgårdh-Nilsson A.	Arterioscler Thromb Vasc Biol	2012
Increased inflammation in atherosclerotic lesions of diabetic Akita-LDLr−/− mice compared to nondiabetic LDLr−/− mice Engelbertsen D, To F, Duner P, Kotova O, Soderberg I, Alm R, Gomez MF, Nilsson J, Bengtsson E.	Experimental Diabetes Research	2012
Modest elevation in BNP in asymptomatic hypertensive patients reflects sub-clinical cardiac remodeling, inflammation and extracellular matrix changes. Phelan D, Watson C, Martos R, Collier P, Patle A, Donnelly S, Ledwidge M, Baugh J, McDonald K.	PLoS One.	2012
Biomarker panel of cardiac and skeletal muscle troponins, fatty acid binding protein 3 and myosin light chain 3 for the accurate diagnosis of cardiotoxicity and musculoskeletal toxicity in rats. Tonomura Y, Matsushima S, Kashiwagi E, Fujisawa K, Takagi S, Nishimura Y, Fukushima R, Torii M, Matsubara M.	Toxicology.	2012
Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging. Kamath AV, Williams SP, Bullens S, Cowan KJ, Stenberg Y, Cherry SR, Rendig S, Kukis DL, Griesemer C, Damico-Beyer LA, Bunting S.	PLoS One	2012
In vitro and clinical studies examining the expression of osteopontin in cigarette smoke-exposed endothelial cells and cigarette smokers. Bishop E, Theophilus EH, Fearon IM.	BMC Cardiovascular Disorders	2012
Arachidonate 15-Lipoxygenase Type B Knockdown Leads to Reduced Lipid Accumulation and Inflammation in Atherosclerosis. Magnusson, LU, Lundqvist A, Karlsson MN, Skalen K, Levin M, Wiklund O, Boren J, Hulten LM.	PLoS One	2012
Genetic Variants in Platelet Factor 4 Modulate Inflammatory and Platelet Activation Biomarkers. Bhatnagar P, Lu X, Evans MK, Laveist TA, Zonderman AB, Carter DL, Arking DE, Fletcher CA.	Circ Cardiovasc Genet.	2012
Salidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosis. Sun L, Isaak CK, Zhou Y, Petkau JC, O K, Liu Y, Siow YL.	Life Sci.	2012
Ways of coping and biomarkers of an increased atherothrombotic cardiovascular disease risk in elderly individuals. von Kanel R, Mausbach BT, Dimsdale JE, Mills PJ, Patterson TL, Ancoli-Israel S, Ziegler MG, Roepke SK, Allison M, Grant I.	Cardiovascular Psychiatry and Neurology	2012
Pharmacologically Dosed Oral Glutamine Reduces Myocardial Injury in Patients Undergoing Cardiac Surgery: A Randomized Pilot Feasibility Trial. Sufit A, Weitzel LB, Hamiel C, Queensland K, Dauber I, Rooyackers O, Wischmeyer PE.	J Parenter Enteral Nutr.	2012
Clinical and biomarker profile of trauma-induced secondary cardiac injury. De'Ath HD, Rourke C, Davenport R, Manson J, Renfrew I, Uppal R, Davies LC, Brohi K.	Br J Surg.	2012
E-Selectin is Elevated in Cord Blood of South Asian Neonates Compared with Caucasian Neonates. Boon MR, Karamali NS, de Groot CJ, van Steijn L, Kanhai HH, van der Bent C, Berbée JF, Middelkoop B, Rensen PC, Tamsma JT.	J Pediatr.	2011
Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE(-/-) mice. Bernberg E, Ulleryd MA, Johansson ME, Bergström GM.	Atherosclerosis	2011
The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats. Hocher B, Sharkovska Y, Mark M, Klein T, Pfab T.	Int J Cardiol.	2012
Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. Aronis, K.N., Vamvini, M.T., Chamberland, J.P., Sweeney, L.L., Brennan, A.M., Magkos, F., Mantzoros, C.S.	Metabolism.	2011
Androgen stimulates endothelial cell proliferation via an androgen receptor/VEGF/cyclin A-mediated mechanism. Cai, J., Hong, Y., Weng, C., Tan, C., Imperato-McGinley, J., Zhu, Y.S.	Am J Physiol Heart Circ Physiol.	2011
Rip2 Deficiency Leads to Increased Atherosclerosis Despite Decreased Inflammation. Levin, M.C., Jirholt, P., Wramstedt, A., Johansson, M.E., Lundberg, A.M., Gustafsson, T.M., Ståhlman, M., Fogelstrand, P., Brisslert, M., Fogelstrand, L., Yan, Z.Q., Hansson, G.K., Björkback, H., Olofsson, S.O., Borén, J.	Circ Res.	2011
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Rayner, K.J., Esau, C.C., Hussain, F.N., McDaniel, A.L., Marshall, S.M., van Gils, J.M., Ray, T.D., Sheedy, F.J., Goedeke, L., Liu, X., Khatsenko, O.G., Kaimal, V., Lees, C.J., Fernandez-Hernando, C., Fisher, E.A., Temel, R.E., Moore, K.J.	Nature.	2011
Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period. van Bussel, B.C., Schouten, F., Henry, R.M., Schalkwijk, C.G., de Boer, M.R., Ferreira, I., Smulders, Y.M., Twisk, J.W., Stehouwer, C.D.	Hypertension.	2011
Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure? Collier, P., Watson, C.J., Voon, V., Phelan, D., Jan, A., Mak, G., Martos, R., Baugh, J.A., Ledwidge, M.T., McDonald, K.M.	Eur J Heart Fail.	2011

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