Patterns of Th1/Th2 Cytokines Predict Clinical Response in Multiple Sclerosis Patients Treated with Glatiramer Acetate.

Tumani, H., Kassubek, J., Hijazi, M., Lehmensiek, V., Unrath, A., Sussmuth, S., Lauda, F., Kapfer, T., Fang, L., Senel, M., Brettschneider, J.

Journal	Eur Neurol.		Year	2011
Species	Human		Volume	65 (3)
Analytes Measured	IFN-γ, IL-10, IL-2, IL-4, Osteopontin		Page #	164-169
Matrix Tested	Serum		Category	Cytokines & Chemokines

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Abstract

The patterns of Th1/Th2 cytokines in relapsing-remitting multiple sclerosis were analyzed to evaluate their relevance as biomarkers of therapy response to glatiramer acetate (GA). Serum interferon-γ (IFN-γ), osteopontin and interleukin (IL)-2, IL-4, and IL-10 were measured in 19 relapsing-remitting multiple sclerosis patients treated with GA in a prospective study over 3 years. The quotient (IL-2 + IFN-γ)/(IL-4 + IL-10) was elevated in patients with relapses as compared to relapse-free patients after 12 (p = 0.04), 24 (p = 0.02) and 36 months (p = 0.04). Our study indicates that specific patterns of Th1/Th2 cytokines predict the response to GA therapy.

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