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Enter author, analyte, or keyword to search publications.
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| NEW! Brodlie, M., McKean, M.C., Johnson, G.E., Anderson, A.E., Hilkens, C.M., Fisher, A.J., Corris, P.A., Lordan, J.L., Ward, C. (2011) Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease. Eur Respir J. Vol. 37(6):1378-85.
Interleukin, IL6, IL8, IL17, granulocyte-macrophage colony-stimulating factor, neutrophils, Newcastle University
Analytes tested using MSD® assays: GM-CSF, IL-6, IL-8, IL-17
Matrix tested: Cell culture supernatants, airway lavage supernatants
Summary: This study investigated the role of IL-17 in the pathogenesis of cystic fibrosis by performing immunohistochemistry in explanted lung tissue from patients with advanced cystic fibrosis lung disease.
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| NEW! Cantisani, R., Sammicheli, C., Tavarini, S., D'Oro, U., Wack, A., Piccioli, D. (2011) Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells. Hum Immunol. 2011 Aug 10. [Epub ahead of print].
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Novartis Vaccines and Diagnostics
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha
Matrix tested: Cell culture supernatants
Summary: In this study, the mechanism of cross-activation of plasmacytoid dendritic cells and myeloid dendritic cells was investigated.
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| NEW! Cole, J.T., Yarnell, A., Kean, W.S., Gold, E., Lewis, B., Ren, M., McMullen, D.C., Jacobowitz, D.M., Pollard, H.B., O'Neill, J.T., Grunberg, N.E., Dalgard, C.L., Frank, J.A., Watson, W.D. (2011) Craniotomy: true sham for traumatic brain injury, or a sham of a sham?. J Neurotrauma. Vol. 28(3):359-69
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL4, IL5, IL8, IL13, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Uniformed Services University of the Health Sciences, magnetic resonance imaging
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, IL-5, IL-13, KC/GRO/CINC, TNF-alpha (MSD Rat Demonstration 7-Plex Ultra-Sensitive Kit)
Matrix tested: Rat cortical tissue homogenates
Summary: This study investigated whether "sham"—a craniotomy procedure done on controls for traumatic brain injury studies—can cause unique brain injuries that can confound the interpretation of conventional experiments.
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| NEW! Dabitao, D., Margolick, J.B., Lopez, J., Bream, J.H. (2011) Multiplex measurement of proinflammatory cytokines in human serum: Comparison of the Meso Scale Discovery electrochemiluminescence assay and the Cytometric Bead Array. J Immunol Methods. Vol. 372(1-2):71-7.
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, Johns Hopkins Bloomberg School of Public Health
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha
Matrix tested: Human serum
Summary: This study evaluated the performance of 2 multiplex platforms—the cytometric bead assay and the MSD assay—for the measurement of proinflammatory cytokines in HIV-infected patients and compared them with healthy individuals. The MSD assay gave better quantification of both endogenous and exogenously added cytokines in both HIV-infected and uninfected samples.
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| NEW! Hams, E., Saunders, S.P., Cummins, E.P., O'Connor, A., Tambuwala, M.T., Gallagher, W.M., Byrne, A., Campos-Torres, A., Moynagh, P.M., Jobin, C., Taylor, C.T., Fallon, P.G. (2011) The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by b1 cells. Shock. Vol. 36(3):295-302.
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, lipopolysaccharide, LPS, hypoxia, Trinity College
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, KC/GRO/CINC, IL-10, IL-12p70, TNF-alpha (MSD Mouse ProInflammatory 7-Plex Ultra-Sensitive Kit)
Matrix tested: Mouse serum
Summary: This paper investigated the mechanisms by which the hydroxylase inhibitor, dimethyloxallyl glycine (DMOG) is protective against acute systemic inflammation caused by LPS.
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| NEW! Holmes, C., Cunningham, C., Zotova, E., Culliford, D., Perry, V.H. (2011) Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology. Vol. 77(3):212-8.
Interleukin, IL6, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, University of Southampton
Analytes tested using MSD assays: IL-6, TNF-alpha
Matrix tested: Human serum
Summary: This study evaluated whether elevated levels of proinflammatory cytokines contribute to neuropsychiatric symptoms associated with sickness behavior in Alzheimer's disease patients.
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| NEW! Horowitz, N.S., Penson, R.T., Duda, D.G., di Tomaso, E., Boucher, Y., Ancukiewicz, M., Cohen, K.S., Berlin, S., Krasner, C.N., Moses, M.A., Jain, R.K. (2011) Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma. Clin Ovarian Cancer Other Gynecol Malig. Vol. 4(1):26-33.
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL6, IL8, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, vascular endothelial growth factor receptor, placental growth factor, basic fibroblast growth factor, Brigham and Women's Hospital
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, TNF-alpha, basic FGF, PlGF, VEGF, soluble VEGFR1
Matrix tested: Human plasma
Summary: This paper provides the results of a toxicity and efficacy study of a combination therapy of bevacizumab with gemcitabine and oxaliplatin in patients with ovarian cancer.
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| NEW! Kang, J.G., Amar, M.J., Remaley, A.T., Kwon, J., Blackshear, P.J., Wang, P.Y., Hwang, P.M. (2011) Zinc Finger Protein Tristetraprolin Interacts with CCL3 mRNA and Regulates Tissue Inflammation. J Immunol. Vol. 187(5):2696-701.
National Institute of Health, NIH
Analytes tested using MSD assays: IL-1beta, TNF-alpha
Matrix tested: Mouse plasma
Summary: The aim of this study was to investigate the interaction between tristetraprolin (TTP), a zinc finger protein, and CCL-3/MIP-1alpha mRNA in relation to inflammatory arthritis and atherosclerosis using a mouse model.
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| NEW! Karnell, J.L., Karnell, F.G. 3rd, Stephens, G.L., Rajan, B., Morehouse, C., Li, Y., Swerdlow, B., Wilson, M., Goldbach-Mansky, R., Groves, C., Coyle, A.J., Herbst, R., Ettinger, R. (2011) Mycophenolic Acid Differentially Impacts B Cell Function Depending on the Stage of Differentiation. J Immunol. 2011 Aug 26. [Epub ahead of print].
Interleukin, IL2, IL4, IL5, IL10, IL12, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, MedImmune
Analytes tested using MSD assays: IFN-gamma, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13
Matrix tested: Cell culture supernatants
Summary: This study investigated the mechanism of action of mycophenolic acid—an immunosuppressant agent—with regard to inhibition of B-cell activation and plasma cell differentiation.
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| NEW! Kennedy-Crispin, M., Billick, E., Mitsui, H., Gulati, N., Fujita, H., Gilleaudeau, P., Sullivan-Whalen, M., Johnson-Huang, L.M., Suárez-Fariñas, M., Krueger, J.G. (2011) Human Keratinocytes' Response to Injury Upregulates CCL20 and Other Genes Linking Innate and Adaptive Immunity. J Invest Dermatol. 2011 Sep 1. [Epub ahead of print].
Macrophage Inflammatory Protein-3, MIP-3a, MIP3a, MIP-3a, MIP3a, MIP3alpha, Rockefeller University
Analytes tested using MSD assays: CCL20/MIP-3alpha
Matrix tested: Cell culture supernatants
Summary: The aim of this study was to investigate whether keratinocytes contribute to cell-mediated immunity during wound healing.
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| NEW! Kissner, T.L., Moisan, L., Mann, E., Alam, S., Ruthel, G., Ulrich, R.G., Rebek, M., Rebek, J. Jr, Saikh, K.U. (2011) A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1 (IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice. J Biol Chem. Vol. 286(36):31385-96.
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL2, IL6, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Scripps Research Institute
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-6, TNF-alpha
Matrix tested: Cell culture supernatants
Summary: This study evaluated whether MyD88 protein can be utilized as a potential target for therapeutic intervention of staphylococcal enterotoxin B induced proinflammatory cytokine response and toxicity.
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| NEW! Krause, M.L., Davis, J.M. 3rd, Knutson, K.L., Strausbach, M.A., Crowson, C.S., Therneau, T.M., Wettstein, P.J., Matteson, E.L., Gabriel, S.E. (2011) Assessing immune function by profiling cytokine release from stimulated blood leukocytes and the risk of infection in rheumatoid arthritis. Clin Immunol. 2011 May 30. [Epub ahead of print].
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL2, IL4, IL5, IL6, IL7, IL8, IL10, IL12, IL13, IL17, Monocyte chemotactic protein-1, macrophage inflammatory protein 1 beta, Granulocyte colony-stimulating factor, Granulocyte macrophage colony-stimulating factor, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Mayo Clinic
Analytes tested using MSD assays: G-CSF, GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17a, MCP-1, MIP-1beta, TNF-alpha
Matrix tested: Peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: This paper provides the results of a longitudinal study aimed at determining the relation between ex vivo cytokine production by stimulated peripheral blood mononuclear cells from rheumatoid arthritis patients and the risk of infection within 6-months.
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| NEW! Mattsson, N., Tabatabaei, S., Johansson, P., Hansson, O., Andreasson, U., Månsson, J.E., Johansson, J.O., Olsson, B., Wallin, A., Svensson, J., Blennow, K., Zetterberg, H. (2011) Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility. Neuromolecular Med. Vol. 13(2):151-9.
MCP-1, monocyte chemotactic protein-1, microglia, YKL-40, University of Gothenburg
Analytes tested using MSD assays: MCP-1/CCL2
Matrix tested: Human cerebrospinal fluid (CSF)
Summary: This study analyzed several putative biomarkers of microglial activity in Alzheimer's disease patients, mild cognitive impairment (MCI) patients, individuals with other dementias, and in controls to evaluate whether microglial activation contributes to AD pathogenesis.
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| NEW! Nieman, D.C., Konrad, M., Henson, D.A., Kennerly, K., Shanely, R.A., Wallner-Liebmann, S.J. (2011) Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity. J Interferon Cytokine Res. 2011 Sep 14. [Epub ahead of print].
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL2, IL6, IL8, IL10, IL12p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, granulocyte-macrophage colony-stimulating factor, Appalachian State University
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha
Matrix tested: Human plasma
Summary: The purpose of this study was to investigate whether factors such as age, body composition, physical fitness, training habits, systemic inflammation, and metabolic demands have an influence on the degree of inflammation experienced by trained cyclists.
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| NEW! Patel, L., Sun, W., Glasson, S.S., Morris, E.A., Flannery, C.R., Chockalingam, P.S. (2011) Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage. BMC Musculoskelet Disord. Vol. 12:164.
Interleukin, IL6, IL8, Pfizer
Analytes tested using MSD assays: IL-6, IL-8, MSD Human ProInflammatory 7-Plex Kit
Matrix tested: Cell culture supernatants
Summary: This study analyzed the expression levels of Tenascin-C mRNA and protein in normal and osteoarthritic human cartilage, and assessed the role of Tenascin-C in the induction of inflammatory markers and proteoglycan degradation in articular cartilage.
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| NEW! Pine, S.R., Mechanic, L.E., Enewold, L., Chaturvedi, A.K., Katki, H.A., Zheng, Y.L., Bowman, E.D., Engels, E.A., Caporaso, N.E., Harris, C.C. (2011) Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. J Natl Cancer Inst. Vol. 103(14):1112-22.
Interleukin, IL6, IL8, National Cancer Institute
Analytes tested using MSD assays: IL-6, IL-8
Matrix tested: Human serum
Summary: The aim of this study was to evaluate the association between circulating IL-6 and IL-8 levels and lung cancer, and to determine if the biomarkers were predictive of future lung cancer diagnosis.
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| NEW! Reiser, V., Smith, R.C., Xue, J., Kurtz, M.M., Liu, R., Legrand, C., He, X., Yu, X., Wong, P., Hinchcliffe, J.S., Tanen, M.R., Lazar, G., Zieba, R., Ichetovkin, M., Chen, Z., O'Neill, E.A., Tanaka, W.K., Marton, M.J., Liao, J., Morris, M., Hailman, E., Tokiwa, G.Y., Plump, A.S. (2011) High-Throughput Simultaneous Analysis of RNA, Protein, and Lipid Biomarkers in Heterogeneous Tissue Samples. Clin Chem. 2011 Sep 13. [Epub ahead of print].
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL6, macrophage inflammatory protein-1, monocyte chemotactic protein-1, regulated on activation normal T-cell expressed and secreted, C-reactive protein, , tumor necrosis factor receptor-II, intercellular adhesion molecule-1, myeloperoxidase, Merck Sharp & Dohme Corporation
Analytes tested using MSD assays: IL-1beta, IL-6, MIP-1, MCP-1, RANTES, CRP, CD68, TNFRII, ICAM-1, MPO
Matrix tested: Tissue homogenate supernatants
Summary: In this study, a new semi-automated tissue processing method called tissue milling and division (TMAD) was validated for the high-throughput sampling and increased sample recovery from small amounts of heterogeneous tissue specimens.
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| NEW! Schioppa, T., Moore, R., Thompson, R.G., Rosser, E.C., Kulbe, H., Nedospasov, S., Mauri, C., Coussens, L.M., Balkwill, F.R. (2011) B regulatory cells and the tumor-promoting actions of TNF-a during squamous carcinogenesis. Proc Natl Acad Sci U S A. Vol. 108(26):10662-7.
Interleukin, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Queen Mary University of London
Analytes tested using MSD assays: IFN-gamma, IL-10, IL-12 total
Matrix tested: Cell culture supernatants
Summary: The aim of this study was to test whether B-cells act as effector cells for TNF-alpha mediated tumor promotion.
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| Bafadhel, M., McKenna, S., Terry, S., Mistry, V., Reid, C., Haldar, P., McCormick, M., Haldar, K., Kebadze, T., Duvoix, A., Lindblad, K., Patel, H., Rugman, P., Dodson, P., Jenkins, M., Saunders, M., Newbold, P., Green, R.H., Venge, P., Lomas, D.A., Barer, M.R., Johnston, S.L., Pavord, I.D., Brightling, C.E. (2011) Acute Exacerbations of COPD: Identification of Biological Clusters and Their Biomarkers. Am J Respir Crit Care Med. 2011 Jun 16. [Epub ahead of print].
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL8, IL10, IL12, IL13, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, IL6, IL8, Interleukin-6 Receptor, Tumor Necrosis Factor Receptor, TNFR1, TNFR2, Monocyte Chemotactic Protein, Macrophage Inflammatory Protein, MIP-1b, MIP1b, Regulated upon Activation, Normal T-cell Expressed, and Secreted, Interferon-inducible T cell Alpha-Chemoattractant, CK-MB, CKMB
Analytes tested using MSD assays: IL-1beta, IL-8, IL-6, TNF-alpha, TNF-RI, TNF-RII, CCL26/Eotaxin-3, CCL17/TARC, IL-4, IL-5, IL-13, CCL2/MCP-1, CCL4/MIP-1beta, IL-10, IL-17A, IFN-gamma, CXCL10/IP-10, CXCL11/I-TAC, CCL3/MIP-1alpha, CCL13/MCP-4, CSF2/GMCSF, IL-6R, CCL5/RANTES, Serum Amyloid A, Creatine Kinase-MB, Myoglobin, Troponin-1
Matrix tested: Human serum and sputum
Summary: In this study, the inflammatory biomarker profile of chronic obstructive pulmonary disorder (COPD) exacerbation was investigated.
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| Bordner, K.A., Kitchen, R.R., Carlyle, B., George, E.D., Mahajan, M.C., Mane, S.M., Taylor, J.R., Simen, A.A. (2011) Parallel declines in cognition, motivation, and locomotion in aging mice: Association with immune gene upregulation in the medial prefrontal cortex. Exp Gerontol. [Epub ahead of print].
Interferon, IFN-?, IFN?, IFNg, IFN-g, IFNgamma, interleukin, IL6, IL10, IL12, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL12-p70, IL13, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12, KC/GRO/CINC/CXCL1, TNF-alpha
Matrix tested: Mouse serum
Summary: This study used aging mouse as a model organism for understanding the mechanisms responsible for age-related changes in cognition, motivation, and motoric behavior, similar to that observed in humans.
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| Botelho, F.M., Nikota, J., Bauer, C., Davis, N.H., S. Cohen, E., Anderson, I.K., Coyle, A.J., Kolbeck, R., Humbles, A.A., Stämpfli, M.R., Sleeman, M.A. (2011) A Mouse GM-CSFR Antibody Attenuates Neutrophilia in Mice Exposed to Cigarette Smoke. Eur Respir J. 2011 Mar 24. [Epub ahead of print].
Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL4, IL8, CXCL1, IL12
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, KC/GRO/CINC, IL-12
Matrix tested: Mouse bronchoalveolar lavage (BAL) fluid and lung homogenates
Summary: In this study, the role of GM-CSF in cigarette-smoke induced inflammation was examined in sub-chronically exposed mice by using an anti-GM-CSF antibody and an antibody against the GM-CSF receptor alpha-chain.
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| Boulware, D.R., Hullsiek, K.H., Puronen, C.E., Rupert, A., Baker, J.V., French, M.A., Bohjanen, P.R., Novak, R.M., Neaton, J.D., Sereti, I; for the INSIGHT Study Group. (2011) Higher Levels of CRP, D-dimer, IL-6, and Hyaluronic Acid Before Initiation of Antiretroviral Therapy (ART) Are Associated With Increased Risk of AIDS or Death. J Infect Dis. Vol. 203(11):1637-1646.
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL12, IL4, IL13, IL17, IL10, IL2, IL15, IL8, IL6, IL8, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, Monocyte Chemotactic Protein, Macrophage Inflammatory Protein, MIP-1b, MIP1b, Interferon gamma-induced protein 10, macrophage-derived chemokine, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-12, IL-4, IL-13, IL-17, IL-10, IL-2, IL-15, IL-8, CXCL1/Gro-alpha, CXCL10/IP-10, CCL3/MIP-1alpha, CCL4/MIP-1beta, CCL11/Eotaxin-1, CCL13/MCP-4, CCL17/TARC, CCL22/MDC, CCL26/Eotaxin-3/MIP-4alpha, TNF-alpha
Matrix tested: Human plasma
Summary: In this study, biomarkers were evaluated to identify high risk patients who may incur adverse clinical events upon anti-retroviral therapy.
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| Bragt, M.C., Mensink, R.P. (2011) Comparison of the effects of n-3 long chain polyunsaturated fatty acids and fenofibrate on markers of inflammation and vascular function, and on the serum lipoprotein profile in overweight and obese subjects. Nutr Metab Cardiovasc Dis. [Epub ahead of print].
TNFalpha, TNFa, TNF-a, TNF?, TNF-?, Tumor Necrosis Factor Receptor, TNFR1, TNFR2, Monocyte Chemotactic Protein, Intercellular Adhesion Molecule, ICAM1, Vascular Cell Adhesion Molecule, VCAM1
Analytes tested using MSD assays: ICAM-1, MCP-1, VCAM-1, TNF-R1, TNF-R2
Matrix tested: Human plasma
Summary: In this study, the effects of n-3 long chain polyunsaturated fatty acids (n3-LCPUFA) and fenofibrate on a range of cardiovascular disease biomarkers were compared in overweight and obese individuals. Fenofibrate and n3-LCPUFA are both activators of PPARa, which in turn can lower serum triglycerides and increase HDL.
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| Carlsson, A., Wuttge, D.M., Ingvarsson, J., Bengtsson, A.A., Sturfelt, G., Borrebaeck, C.A., Wingren, C. (2011) Serum protein profiling of systemic lupus erythematosus and systemic sclerosis using recombinant antibody microarrays. Mol Cell Proteomics. [Epub ahead of print].
Interferon, IFN-?, IFN?, IFNg, IFN-g, IFNgamma, interleukin, IL2, IL4, IL5, IL10, IL12, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL12-p70, IL13, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, SLE, SSc
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha (MSD Human TH1/TH2 10-Plex Ultra-Sensitive Kit)
Matrix tested: Human serum
Summary: This study examined the potential of a recombinant antibody microarray technique to profile the serum proteins in systemic lupus erythematosus and systemic sclerosis using crude, directly biotinylated sera.
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| Cereda, V., Vergati, M., Huen, N.Y., di Bari, M.G., Jochems, C., Intrivici, C., Gulley, J.L., Apelian, D., Schlom, J., Tsang, K.Y. (2011) Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells. Vaccine. 2011 May 11. [Epub ahead of print].
Granulocyte macrophage colony stimulating factor, GMCSF, IL2, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, IL12-p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, Tumor Necrosis Factor Receptor, lipopolysaccharide
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha (MSD Human ProInflammatory 9-Plex)
Matrix tested: Cell culture supernatants
Summary: This study examined the effects of yeast-treated dendritic cells on the overall population of CD4+ T-cells and the ratio of CD4+ effector cells to regulatory T-cells.
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| Cohen, L., Parker, P.A., Vence, L., Savary, C., Kentor, D., Pettaway, C., Babaian, R., Pisters, L., Miles, B., Wei, Q., Wiltz, L., Patel, T., Radvanyi, L. (2011) Presurgical stress management improves postoperative immune function in men with prostate cancer undergoing radical prostatectomy. Psychosom Med. Vol. 73(3):218-25. Epub 2011 Jan 21.
Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, IL12-p70 tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha (MSD Human ProInflammatory 7-Plex)
Matrix tested: Human serum
Summary: The aim of this study was to test the beneficial effects of stress management on immune-outcomes for prostate cancer patients undergoing prostatectomy.
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| Davis, J.M. 3rd, Knutson, K.L., Strausbauch, M.A., Crowson, C.S., Therneau, T.M., Wettstein, P.J., Roger, V.L., Matteson, E.L., Gabriel, S.E. (2011) A signature of aberrant immune responsiveness identifies myocardial dysfunction in rheumatoid arthritis. Arthritis Rheum. Vol. 63(6):1497-506.
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL5, IL6, IL7, IL8, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, Monocyte Chemotactic Protein, Macrophage Inflammatory Protein, MIP-1b, MIP1b, granulocyte colony-stimulating factor, granulocyte macrophage colony-stimulating factor
Analytes tested using MSD assays: G-CSF, GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, MCP-1, MIP-1beta, TNF-alpha
Matrix tested: Peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: The aim of this study was to identify the signature proteins involved in left ventricular diastolic dysfunction (LVDD) in rheumatoid arthritis patients. Ex-vivo cytokine production from PBMC cells obtained from rheumatoid arthritis patients with different degrees of LVDD was analyzed.
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| de Lemos Rieper, C., Galle, P., Pedersen, B.K., Hansen, M.B. (2011) Characterization Of Specific Antibodies Against Cytomegalovirus-Encoded IL-10 Produced By 28% Of The CMV-Seropositive Blood Donors. J Gen Virol. [Epub ahead of print].
Interleukin, IL10, neutralizing antibodies, molecular mimicry
Analytes tested using MSD assays: IL-10
Matrix tested: Human plasma
Summary: The aim of this study was to test the bioactivity of human cytomegalovirus (HCMV) IL-10 in terms of binding and activating human IL-10 receptors. Additionally, the production of specific and neutralizing IgG antibodies against cmvIL-10 by HCMV-infected individuals was also assessed.
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| Dworski, R., Simon, H.U., Hoskins, A., Yousefi, S. (2011) Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways. J Allergy Clin Immunol. Vol. 127(5):1260-6. Epub 2011 Feb 18.
Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL5
Analytes tested using MSD assays: IFN-gamma, IL-5
Matrix tested: Human bronchoalveolar lavage (BAL) fluid
Summary: This study tested whether infiltration of airways with eosinophils and neutrophils results in the formation of extracellular DNA traps in human asthmatic subjects.
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| Eda, H., Burnette, B.L., Shimada, H., Hope, H.R., Monahan, J.B. (2011) Interleukin-1ß-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase-4. Cell Biol Int. Vol. 35(4):355-8.
Interleukin, IL6
Analytes tested using MSD assays: IL-6
Matrix tested: Cell culture medium
Summary: The aim of this study was to elucidate the different pathways that are involved in IL-1beta-induced IL-6 production in lung epithelial cells and in rheumatoid arthritis synovial fibroblasts.
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| Fichorova, R.N., Onderdonk, A.B., Yamamoto, H., Delaney, M.L., DuBois, A.M., Allred, E., Levition, A; for the ELGAN Study Investigators. (2011) Maternal Microbe-Specific Modulation of Inflammatory Response in Extremely Low-Gestational-Age Newborns.mBio 2(1):e00280-10.
CXCL8, CCL2, CCL13, macrophage inflammatory protein 1, CCL4, regulated upon activation, normal T cell expressed and secreted, CCL5, interferon inducible T cell chemoattractant, CXCL11, CD54, CD50, CD106, E-SEL, CD62E, MMP1, MMP9, C reactive protein, SAA, matrix metalloproteinase, myeloperoxidase, vascular endothelial growth factor, VEGFR1, VEGFR2, IGF-BP1, insulin-like growth factor binding protein, Vascular cell adhesion protein 1, serum amyloid A, Inter-Cellular Adhesion Molecule 1, interleukin, IL-1ß, IL1ß, IL1b, IL1beta, IL-1b, IL6, IL6 receptor, IL6R, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, TNFa, TNFR1, TNFR2, IL8, Monocyte chemotactic protein-1, EGLAN, Harvard Medical School
Analytes tested using MSD assays: IL-1beta, IL-6, IL-6R, TNF-alpha, TNF-R1, TNF-R2, IL-8, MCP-1, MCP-4, MIP-1beta, RANTES, I-TAC, ICAM-1, ICAM-3, VCAM-1, E-selectin, MMP-1, MMP-9, CRP, SAA, MPO, VEGF, VEGF-R1, VEGF-R2, IGF-BP-1
Matrix tested: Dried blood spots
Summary: This study evaluated the association between colonization of placenta by vaginal microorganisms and the induction of inflammatory response in the fetus and newborn. MSD multiplex assays were used to examine 25 biomarkers in dried blood spots obtained from 527 preterm newborns.
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| Fidock, M.D., Souberbielle, B.E., Laxton, C., Rawal, J., Delpuech-Adams, O., Corey, T.P., Colman, P., Kumar, V., Cheng, J.B., Wright, K., Srinivasan, S., Rana, K., Craig, C., Horscroft, N., Perros, M., Westby, M., Webster, R., van der Ryst, E. (2011) The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691). Clin Pharmacol Ther. [Epub ahead of print].
Interferon, IFN-?, IFN?, IFNa, IFN-a, IFNalpha, IFN-gamma inducible protein 10, IP10, interleukin, IL6, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?
Analytes tested using MSD assays: IFN-alpha, IL-6, IP-10, TNF-alpha
Matrix tested: Human serum
Summary: The aim of this study was to investigate whether the administration of a TLR-7 agonist would lead to the production of IFN-alpha resulting in an anti-viral response in patients infected with Hepatitis C virus. The safety data for a specific agonist of TLR-7 called PF-4878691 has been provided here.
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| Harris, K., Ream, R., Gao, J., Eichelberger, M.C. (2011) Intramuscular immunization of mice with live influenza virus is more immunogenic and offers greater protection than immunization with inactivated virus. Virol J. Vol. 8:251.
IL2, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL4, IL5, IL8, CXCL1, IL10, IL12p70, IL12-p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC/GRO/CINC, IL-10, IL-12p70, IL-13, TNF-alpha
Matrix tested: Mouse serum and bronchoalveolar lavage (BAL) fluid
Summary: This study compared the cytokine profile, antibody response, and CD8+ T cell response after intramuscular administration of live and inactivated influenza virus in mice.
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| Hecht, J.L., Fichorova, R.N., Tang, V.F., Allred, E.N., McElrath, T.F., Leviton, A; Elgan Study Investigators. (2011) Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA Newborns. Pediatr Res. Vol. 69(1):68-73.
CXCL8, CCL2, CCL13, macrophage inflammatory protein 1, CCL4, regulated upon activation, normal T cell expressed and secreted, CCL5, interferon inducible T cell chemoattractant, CXCL11, CD54, CD50, CD106, E-SEL, CD62E, MMP1, MMP9, C reactive protein, SAA, matrix metalloproteinase, myeloperoxidase, vascular endothelial growth factor, VEGFR1, VEGFR2, IGF-BP1, insulin-like growth factor binding protein, Vascular cell adhesion protein 1, serum amyloid A, Inter-Cellular Adhesion Molecule 1, interleukin, IL-1ß, IL1ß, IL1b, IL1beta, IL-1b, IL6, IL6 receptor, IL6R, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, TNFa, TNFR1, TNFR2, IL8, Monocyte chemotactic protein-1, EGLAN, Beth Israel Deaconess Medical Center
Analytes tested using MSD assays: IL-1beta, IL-6, IL-6R, TNF-alpha, TNF-R1, TNF-R2, IL-8, MCP-1, MCP-4, MIP-1beta, RANTES, I-TAC, ICAM-1, ICAM-3, VCAM-1, E-selectin, MMP-1, MMP-9, CRP, SAA, MPO, VEGF, VEGF-R1, VEGF-R2, IGF-BP-1
Matrix tested: Dried blood spots
Summary: This study examined the levels of 25 of biomarkers in the blood of infants born before the 28th week of gestation and correlated the results with placental examination for inflammatory lesions.
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| Holladay, C., Power, K., Sefton, M., O'Brien, T., Gallagher, W.M., Pandit, A. (2011) Functionalized Scaffold-mediated Interleukin 10 Gene Delivery Significantly Improves Survival Rates of Stem Cells In Vivo. Mol Ther. [Epub ahead of print].
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, IL4, IL5, IL10, IL13
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, IL-5, IL-10, IL-13, KC/GRO/CINC, TNF-alpha
Matrix tested: Rat tissue homogenates
Summary: The aim of this study was to examine the effect of different IL-10 gene therapy techniques on the retention rate of rat mesenchymal stem cells.
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| Hu, X., Du, S., Tunca, C., Braden, T., Long, K.R., Lee, J., Webb, E.G., Dietz, J.D., Hummert, S., Rouw, S., Hegde, S.G., Webber, R.K., Obukowicz, M.G. (2011) The Antagonists But Not Partial Agonists of Glucocorticoid Receptor Ligands Show Substantial Side Effect Dissociation. Endocrinology. [Epub ahead of print].
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6
Matrix tested: Human whole blood and cell culture supernatants
Summary: In this study, the anti-inflammatory properties of several synthetic ligands of glucocorticoid receptor were compared. The ligands ranged from being partial agonists to fully antoagonists of glucocorticoid receptor.
|
| Jiang, C., Zhao, M.L., Scearce, R.M., Diaz, M. (2011) Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis. Arthritis Rheum. Vol. 63(4):1086-96.
Interferon, IFN-?, IFN?, IFNg, IFN-g, IFNgamma, interleukin, IL2, IL4, IL5, IL10, IL12, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL12-p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, systemic lupus erythematosus, SLE
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC/GRO/CINC/CXCL1, IL-10, IL-12 total, TNF-alpha (MSD Mouse TH1/TH2 9-Plex Ultra-Sensitive Kit)
Matrix tested: Mouse serum and cell culture supernatants
Summary: This study investigated the role of IgM autoantibodies in lupus nephritis in a mouse model.
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| Jones, G.J., Pirson,C., Gideon, H.P., Wilkinson, K.A., Sherman, D.R., Wilkinson, R.J., Hewinson, R.G., Vordermeier, H.M. (2011) Immune Responses to the Enduring Hypoxic Response Antigen Rv0188 Are Preferentially Detected in Mycobacterium bovis Infected Cattle with Low Pathology. PLoS One. 2011; 6(6): e21371.
IL2, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL4, IL10, IL12, macrophage inflammatory protein, MIP-1b, MIP1b, MIP1beta, MIP1ß, MIP-1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, IL-10, IL-12, MIP-1beta, TNF-alpha
Matrix tested: Bovine plasma
Summary: The aim of this study was to evaluate gene products from different regulons to identify antigens that have the ability to stimulate an immune response in latent mycobacterial infection in cattle.
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| Jornayvaz, F.R., Birkenfeld, A.L., Jurczak, M.J., Kanda, S., Guigni, B.A., Jiang, D.C., Zhang, D., Lee, H.Y., Samuel, V.T., Shulman, G.I. (2011) Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc Natl Acad Sci U S A. Vol. 108(14):5748-52.
Interferon, IFN-?, IFN?, IFNg, IFN-g, IFNgamma, interleukin, IL6, IL10, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, protein kinase C, ceramides, insulin receptor kinase, type 2 diabetes
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, TNF-alpha
Matrix tested: Mouse plasma
Summary: In this study, the role of liver acylCoA-diacylglycerol acyltransferase (DAGT2) and other lipid intermediates in conferring insulin resistance was examined in a mouse model of severe hepatic steatosis.
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| Kelly, R.J., Rajan, A., Force, J., Keen, C., Cao, L., Yu, Y., Choyke, P.L., Turkbey, B., Raffeld, M., Xi, L., Steinberg, S.M., Wright, J.J., Lopez-Chavez, A., Kummar, S., Guttierrez, M., Giaccone, G. (2011) Evaluation of KRAS mutations, angiogenic biomarkers and DCE-MRI in patients with advanced non-small cell lung cancer receiving sorafenib. Clin Cancer Res. 2011 Jan 11. [Epub ahead of print].
Vascular endothelial growth factor receptor, placental growth factor, basic fibroblast growth factor, National Cancer Institute
Analytes tested using MSD assays: VEGF, PlGF, sVEGFR1, bFGF
Matrix tested: Human plasma
Summary: This paper provides the results of a phase II clinical trial of sorafenib in patients with advanced non-small-cell lung cancer and having different KRAS mutational status. Sorafenib is a small molecular inhibitor of several tyrosine protein kinases and targets Raf and VEGFR.
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| Knothe, S., Mutschler, V., Rochlitzera, S., Winkler, C., Ebensen, T., Guzman, C.A., Hohlfeld, J., Braun, A., Muller, M. (2011) The NKT cell ligand agalactosylceramide suppresses allergic airway inflammation by induction of a Th1 response. Clin Vaccine. Article in Press.
Interferon, IFN-?, IFN?, IFNg, IFN-g, IFNgamma, interleukin, IL2, IL4, IL5, IL10, IL12, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL12-p70, IL13, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?
Analytes tested using MSD assays:
- IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha (MSD Human TH1/TH2 10-Plex Ultra-Sensitive Kit)
- IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC/GRO/CINC/CXCL1, IL-10, IL-12 total, TNF-alpha (MSD Mouse TH1/TH2 9-Plex Ultra-Sensitive Kit)
Matrix tested: Human and mouse cell culture supernatants, mouse bronchoalveolar lavage fluid (BALF)
Summary: This study examined the immunomodulatory potential of a synthetic glycolipid alpha-galactosylceramide.to treat allergic inflammation by the induction of a compensating TH1 immune response.
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| Kominsky, D.J., Keely, S., Macmanus, C.F., Glover, L.E., Scully, M., Collins, C.B., Bowers, B.E., Campbell, E.L., Colgan, S.P. (2011) An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling. J Immunol. Vol. 186(11):6505-14.
Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma
Analytes tested using MSD assays: IFN-gamma
Matrix tested: Mouse colon tissue homogenates
Summary: The aim of this study was to determine the metabolic changes that are associated with intestinal inflammation in murine models of inflammatory bowel disease as well as in cell models of mucosal inflammation.
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| Lan, H., Cheng, C.C., Kowalski, T.J., Pang, L., Shan, L., Chuang, C.C., Jackson, J., Rojas-Triana, A., Bober, L., Liu, L., Voigt, J., Orth, P., Yang, X., Shipps, G.W. Jr, Hedrick, J.A. (2011) Small molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity. J Lipid Res. [Epub ahead of print].
monocyte chemotactic protein-1, MCP1, Monocyte chemoattractant protein-1, fatty acid binding protein-4, triglyceride
Analytes tested using MSD assays: MCP-1
Matrix tested: Cell culture supernatants (THP-1 macrophage cell line)
Summary: In this study, a series of new inhibitors of fatty acid binding protein-4 (FABP-4) were characterized in vitro as well as in vivo, and the results were compared to BMS309403, a known inhibitor of FABP-4.
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| Langsdorf, E.F., Mao, X., Chang, S.L. (2011) A role for reactive oxygen species in endotoxin-induced elevation of MOR expression in the nervous and immune systems. J Neuroimmunol. 2011 Jun 16. [Epub ahead of print].
Granulocyte macrophage colony stimulating factor, GMCSF, IL2, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, IL12-p70 tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, Tumor Necrosis Factor Receptor, lipopolysaccharide
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha (MSD Human ProInflammatory 9-Plex)
Matrix tested: Cell culture supernatants
Summary: The aim of this study was to elucidate the mechanism by which LPS modifies the expression of mu-opioid receptor (MOR) in neuronal cells and immune-cells.
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| Leng, S.X., Li, H., Xue, Q.L., Tian, J., Yang, X., Ferrucci, L., Fedarko, N., Fried, L.P., Semba, R.D. (2011) Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults. Exp Gerontol. 2011 Apr 13. [Epub ahead of print].
Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma
Analytes tested using MSD assays: IFN-gamma
Matrix tested: Human serum
Summary: This study examined the presence of Cytomegalovirus DNA in the peripheral monocytes of older individuals, and correlated the results with CMV IgG serology and levels of neopterin in serum.
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| Leng, S.X., Tian, X., Matteini, A., Li, H., Hughes, J., Jain, A., Walston, J.D., Fedarko, N.S. (2011) IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adult. Age Ageing. Vol. 40(4):475-81. Epub 2011 May 17.
tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, juvenile dermatomyositis, systemic lupus erythematosus
Analytes tested using MSD assays: IL-6
Matrix tested: Human serum
Summary: This study investigated the role of serum neopterin in frailty, and its dependence on IL-6 levels.
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| Leviton, A., Kuban, K.C., Allred, E.N., Fichorova, R.N., O'Shea, T.M., Paneth, N.; for the ELGAN Study Investigators. (2011) Early postnatal blood concentrations of inflammation-related proteins and microcephaly two years later in infants born before the 28th post-menstrual week. Early Hum Dev. 2011 Feb 17. [Epub ahead of print].
CXCL8, CCL2, CCL13, macrophage inflammatory protein 1, CCL4, regulated upon activation, normal T cell expressed and secreted, CCL5, interferon inducible T cell chemoattractant, CXCL11, CD54, CD50, CD106, E-SEL, CD62E, MMP1, MMP9, C-reactive protein, Serum amyloid A, matrix metalloproteinase, myeloperoxidase, vascular endothelial growth factor, VEGFR1, VEGFR2, IGF-BP1, insulin-like growth factor binding protein, Vascular cell adhesion protein 1, serum amyloid A, Inter-Cellular Adhesion Molecule 1, interleukin, IL-1ß, IL1ß, IL1b, IL1beta, IL-1b, IL6, IL6 receptor, IL6R, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, TNFa, TNFR1, TNFR2, IL8, Monocyte chemotactic protein-1, EGLAN, Harvard Medical School
Analytes tested using MSD assays: IL-1beta, IL-6, IL-6R, TNF-alpha, TNF-R1, TNF-R2, IL-8, MCP-1, MCP-4, MIP-1beta, RANTES, I-TAC, ICAM-1, ICAM-3, VCAM-1, E-selectin, MMP-1, MMP-9, CRP, SAA, MPO, VEGF, VEGF-R1, VEGF-R2, IGF-BP-1
Matrix tested: Dried blood spots
Summary: This study evaluated the association between elevated blood concentrations of inflammation-related proteins shortly after birth of pre-term infants and their small head circumference at two years of age.
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| Leviton, A., Kuban, K., O'Shea, T.M., Paneth, N., Fichorova, R., Allred, E.N., Dammann, O. (2011) The Relationship between Early Concentrations of 25 Blood Proteins and Cerebral White Matter Injury in Preterm Newborns: The ELGAN Study. J Pediatr. 2011 Jan 14. [Epub ahead of print].
CXCL8, CCL2, CCL13, macrophage inflammatory protein 1, CCL4, regulated upon activation, normal T cell expressed and secreted, CCL5, interferon inducible T cell chemoattractant, CXCL11, CD54, CD50, CD106, E-SEL, CD62E, MMP1, MMP9, C reactive protein, SAA, matrix metalloproteinase, myeloperoxidase, vascular endothelial growth factor, VEGFR1, VEGFR2, IGF-BP1, insulin-like growth factor binding protein, Vascular cell adhesion protein 1, serum amyloid A, Inter-Cellular Adhesion Molecule 1, interleukin, IL-1ß, IL1ß, IL1b, IL1beta, IL-1b, IL6, IL6 receptor, IL6R, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, TNFa, TNFR1, TNFR2, IL8, Monocyte chemotactic protein-1, EGLAN, Harvard Medical School
Analytes tested using MSD assays: CRP, SAA, MPO, IL-1beta, IL-6, IL-6R, TNF-alpha, TNF-R1, TNF-R2, IL-8, MCP-1, MCP-4, MIP-1beta, RANTES, I-TAC, ICAM-1, ICAM-3, VCAM-1, E-selectin, MMP-1, MMP-9, VEGF, VEGF-R1, VEGF-R2, IGF-BP-1
Matrix tested: Dried blood spots
Summary: The aim of this study was to investigate whether inflammation contributes to cerebral white matter damage in preterm infants. Blood levels of 25 biomarkers were evaluated in 939 infants born before the 28th week of gestation and were correlated with the results obtained from brain ultrasound scans.
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| Lu, H., Yang, Y., Gad, E., Wenner, C.A., Chang, A., Larson, E.R., Dang, Y., Martzen, M., Standish, L.J., Disis, M.L. (2011) Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells. Clin Cancer Res. Vol. 17(1):67-76.
interferon, IFN-g, IFNg, IFN-?, IFN?, IFNgamma, interleukin, IL2, IL4, IL5, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, TNFa, University of Washington, Seattle
Analytes tested using MSD assays: IFN-gamma, IL-2, IL-4, IL-5, KC/GRO/CINC/CXCL1, TNF-alpha (MSD Mouse TH1/TH2 9-Plex Kit)
Matrix tested: Mouse splenocyte cell culture supernatants
Summary: The aim of this study was to elucidate the mechanism of action of polysaccharide krestin (PSK), a commonly used mushroom extract and an anti-tumor agent. The stimulatory effect of PSK on immune system cells was determined by in vitro analysis in cultured cells, and the anti-tumor action of PSK was tested in vivo in a mouse breast cancer model.
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| Maker, A.V., Katabi, N., Qin, L.X., Klimstra, D.S., Schattner, M., Brennan, M.F., Jarnagin, W.R., Allen, P.J. (2011) Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res. Vol. 17(6):1502-8. Epub 2011 Jan 25.
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL8, IL10, IL12, IL13, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12, IL-13, TNF-alpha
Matrix tested: Human cyst fluid
Summary: In this study, cyst fluid from patients with intraductal papillary mucinous neoplasms of the pancreas was analyzed to determine the key biomarkers indicative of high grade dysplasia.
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| Masson, C.J., Mensink, R.P. (2011) Exchanging Saturated Fatty Acids for (n-6) Polyunsaturated Fatty Acids in a Mixed Meal May Decrease Postprandial Lipemia and Markers of Inflammation and Endothelial Activity in Overweight Men. J Nutr. 2011 Mar 23. [Epub ahead of print].
Interleukin, IL6, IL8, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, monocyte chemoattractant protein-1, Inter-Cellular Adhesion Molecule-1, vascular cell adhesion molecule-1, TNF-receptor
Analytes tested using MSD assays: IL-6, IL-8, TNF-alpha, TNF-RI, TNF-RII, MCP-1, soluble ICAM-1, soluble VCAM-1
Matrix tested: Human plasma and serum
Summary: This study investigated the effects of different types of fat on markers of postprandial inflammation and endothelial activation in overweight men who have a high risk for developing metabolic syndrome.
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| Mathew, P., Wen, S., Morita, S., Thall, P.F. (2011) Placental Growth Factor and Soluble c-Kit Receptor Dynamics Characterize the Cytokine Signature of Imatinib in Prostate Cancer and Bone Metastases. J Interferon Cytokine Res. [Epub ahead of print].
iInterleukin, IL2, IL6, IL8, IL12p70, IL10, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, vascular endothelial growth factor receptor, placental-derived growth factor, VEGFR-1, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, c-kit receptor, soluble vascular endothelial growth factor receptor, basic fibroblast growth factor, sVEGFR1, sVEGFR2, granulocyte macrophage-colony stimulating factor, transforming growth factor-beta, TGF-b, TGFb, TGF-ß, TGFß, matrix metalloproteinase-9
Analytes tested using MSD assays: c-Kit, GM-CSF, IFN-gamma, IL-2, IL-6, IL-8, IL-10, IL-12p70, MMP-9, bFGF, PlGF, VEGF, soluble VEGFR1, soluble VEGFR2/KDR, TGF-beta, TNF-alpha
Matrix tested: Human plasma
Summary: This study was based on the measurement of several angiogenic and inflammatory cytokines in men with metastatic castration-resistant prostate cancer receiving docetaxel, with or without imatinib. Imatinib is an inhibitor of c-Kit and PDGFR.
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| Maciag, A.E., Chakrapani, H., Saavedra, J.E., Morris, N.L., Holland, R.J., Kosak, K.M., Shami, P.J., Anderson, L.M., Keefer, L.K. (2011) The Nitric Oxide Prodrug JS-K Is Effective against Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo: Involvement of Reactive Oxygen Species. J Pharmacol Exp Ther. Vol. 336(2):313-20.
interferon, IFN-g, IFNg, IFN-?, IFN?, IFNgamma, interleukin, IL-1ß, IL1ß, IL1b, IL1beta, IL-1b, IL2, IL4, IL5, IL10, IL12, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, TNFa, SAIC-Frederick, Inc., National Cancer Institute
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-10, IL-12, TNF-alpha (MSD Mouse TH1/TH2 9-Plex Kit)
Matrix tested: Mouse serum
Summary: In this study, the effects of a potent nitric oxide (NO)-releasing drug, JS-K, was tested in vitro in human non–small-cell lung cancer cell lines and in vivo as xenografts tumors.
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| Marchica, C.L., Pinelli, V., Borges, M.C., Zummer, J., Narayanan, V., Iozzo, R.V., Ludwig, M.S. (2011) A Role for Decorin in a Murine Model of Allergen-Induced Asthma. Am J Physiol Lung Cell Mol Physiol. [Epub ahead of print].
Interleukin, IL4, IL5, transforming growth factor-beta
Analytes tested using MSD assays: IL-4, IL-5
Matrix tested: Mouse bronchoalveolar lavage fluid (BALF)
Summary: This study investigated the effect of deficiency of decorin, an extracellular matrix proteoglycan, on the development of ovalbumin induced asthma in a mouse model.
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| McElrath, T.F., Fichorova, R.N., Allred, E.N., Hecht, J.L., Ismail, M.A., Yuan, H., Leviton, A; ELGAN Study Investigators. (2011) Blood protein profiles of infants born before 28th week differ by pregnancy complication. Am J Obstet Gynecol. 2011 Feb 22. [Epub ahead of print].
C-Reactive Protein, serum amyloid A, myeloperoxidase, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, Interleukin-6 Receptor, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, Tumor Necrosis Factor Receptor, TNFR1, TNFR2, Monocyte Chemotactic Protein, Macrophage Inflammatory Protein, MIP-1b, MIP1b, Regulated upon Activation, Normal T-cell Expressed, and Secreted, Intercellular Adhesion Molecule, ICAM1, ICAM3, Vascular Cell Adhesion Molecule, Matrix Metalloproteinase, Vascular Endothelial Growth Factor Receptor, KDR, Flt-1, Insulin Growth Factor Binding Protein-1, Interferon-inducible T cell Alpha-Chemoattractant
Analytes tested using MSD assays: CRP, SAA, MPO, IL-1beta, IL-6, IL-6R, TNF-alpha, TNF-R1, TNF-R2, IL-8, MCP-1, MCP-4, MIP-1beta, RANTES, IGFBP-1, ITAC, ICAM-1, ICAM-3, E-selectin, VCAM-1, MMP-1, MMP-9, VEGF, VEGF-R1, VEGF-R2
Matrix tested: Elution from dried blood spots
Summary: In this study, a range of 25 biomarkers was measured in the blood of 798 infants born before the 28th week of gestation in order to correlate their levels with the disorder that led to preterm delivery.
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| Musselwhite, L.W., Sheikh, V., Norton, T.D., Rupert, A., Porter, B.O., Penzak, S.R., Skinner, J., Mican, J.M., Hadigan, C., Sereti, I. (2011) Markers of endothelial dysfunction, coagulation and tissue fibrosis independently predict venous thromboembolism in HIV. AIDS. Vol. 25(6):787-95.
Interferon, IFN-?, IFN?, IFNg, IFN-g, IFNgamma, interleukin, IL6, IL8, IL10, IL12p70, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, macrophage inflammatory protein 1, interferon inducible protein, C-reactive protein, Serum amyloid A, Vascular cell adhesion protein 1, serum amyloid A, Inter-Cellular Adhesion Molecule 1, Monocyte chemotactic protein-1, macrophage-derived chemokine, tissue inhibitor of metalloproteinase-1
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha, Eotaxin, Eotaxin-3, MIP-1beta, TARC/CCL-17, IP-10, MCP-1, MCP-4, MDC, Thrombomodulin, ICAM-1, ICAM-3, VCAM-1, E-selectin, P-selectin, SAA, CRP, TIMP-1 (tested using MSD Human Vascular Injury I kit, MSD Human Vascular Injury II kit, MSD Human ProInflammatory-7 Ultra-Sensitive kit, MSD Human Chemokine-9 Plex Ultra-Sensitive kit, and MSD Human TIMP-1 kit)
Matrix tested: Human plasma
Summary: In this study, markers of inflammation, endothelial dysfunction, coagulation, and tissue fibrosis were measured in different sets of HIV patients to elucidate whether biomarker analysis can help in identifying patients who have a high risk of venous thromboembolism. Biomarkers of endothelial dysfunction, coagulation, and tissue fibrosis may help identify HIV-infected patients at elevated risk of VTE.
|
| Nic An Ultaigh, S., Saber, T.P., McCormick, J., Connolly, M., Dellacasagrande, J., Keogh, B., McCormack, W., Reilly, M., O'Neill, L.A., McGuirk, P., Fearon, U., Veale, D.J. (2011) Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures. Arthritis Res Ther. Vol. 13(1):R33. [Epub ahead of print].
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-8, TNF-alpha
Matrix tested: PBMC culture supernatants
Summary: The aim of this study was to examine the role of toll-like receptor 2 blockade in inflammation associated with rheumatoid arthritis by using an ex vivo synovial tissue explant culture model.
|
| Niewold, T.B., Wu, S.C., Smith, M., Morgan, G.A., Pachman, L.M. (2011) Familial aggregation of autoimmune disease in juvenile dermatomyositis. Pediatrics. Vol. 127(5):e1239-46. Epub 2011 Apr 18.
Interleukin, IL6, frailty, neopterin, elderly
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Human serum
Summary: This study analyzed the familial aggregation of systemic lupus erythematosus and other autoimmune diseases in juvenile dermatomyositis, and tested its correlation with the levels of IFN-alpha, TNF-alpha, and neopterin.
|
| Noah, T.L., Zhou, H., Monaco, J., Horvath, K., Herbst, M., Jaspers, I. (2011) Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus. Environ Health Perspect. Vol. 119(1):78-83.
influenza, interferon-inducible protein 10, interleukin, tobacco smoke, virus clearance, granulocyte macrophage colony-stimulating factor, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Interleukin, IL2, IL10, IL12p70, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL12-p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-10, IL-12p70, TNF-alpha
Matrix tested: Human nasal lavage fluid (NLF)
Summary: This study investigated whether exposure to airborne pollutants such as cigarette smoke alters the anti-viral response to influenza virus in the human respiratory tract.
|
| O'Leary, S., O'Sullivan, M.P., Keane, J. (2011) IL-10 Blocks Phagosome Maturation in Mycobacterium tuberculosis-infected Human Macrophages. Am J Respir Cell Mol Biol. [Epub ahead of print].
Interleukin, IL10
Analytes tested using MSD assays: IL-10
Matrix tested: Cell culture supernatants
Summary: The aim of this study was to investigate the role of IL-10 in phagosome maturation in human macrophages infected with Mycobacterium tuberculosis.
|
| Rothman, S.M., Ma, L.H., Whiteside, G.T., Winkelstein, B.A. (2011) Inflammatory cytokine and chemokine expression is differentially modulated acutely in the dorsal root ganglion in response to different nerve root compressions. Spine (Phila Pa 1976). Vol. 36(3):197-202.
Interleukin, IL6, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, MIP3
Analytes tested using MSD assays: IL-1beta, IL-6, TNF-alpha, Macrophage Inflammatory Protein-3 (MIP-3)
Matrix tested: Rat dorsal root ganglion homogenates
Summary: The aim of this study was to evaluate the inflammatory response in the dorsal root ganglion after nerve root compression injury.
|
| Sadallah, S., Eken, C., Martin, P.J., Schifferli, J.A. (2011) Microparticles (ectosomes) shed by stored human platelets downregulate macrophages and modify the development of dendritic cells. J Immunol. Vol. 186(11):6543-52. Epub 2011 Apr 27.
Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, IL12-p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha (MSD Human ProInflammatory 7-Plex)
Matrix tested: Cell culture supernatants
Summary: This study investigated whether phosphatidylserine-expressing microparticles that are shed from platelets have the ability to modify the functional properties of dendritic cells and macrophages.
|
| Sithanandam, G., Fornwald, L.W., Fields, J.R., Morris, N.L., Anderson, L.M. (2011) Anti-tumor efficacy of naked siRNAs for ERBB3 or AKT2 against lung adenocarcinoma cell xenografts. Int J Cancer. [Epub ahead of print].
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, IL6, IL10, IL12p70, IL12-p70, lung cancer, siRNA, ERBB3, AKT2
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC/GRO/CINC, TNF-alpha
Matrix tested: Mouse serum
Summary: This study examined the in vivo effects of intravenous administration of small inhibitory RNAs to ERBB3 and Akt in human lung adenocarcinoma xenografts.
|
| Srinivasula, S., Lempicki, R.A., Adelsberger, J.W., Huang, C.Y., Roark, J., Lee, P.I., Rupert, A., Stevens, R., Sereti, I., Lane, H.C., Di Mascio, M., Kovacs, J.A. (2011) Differential effects of HIV viral load and CD4 counts on proliferation of naive and memory CD4 and CD8 T lymphocytes. Blood. 2011 May 11. [Epub ahead of print].
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL2, IL5, IL6, IL10, Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, Tumor Necrosis Factor
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-5, IL-6, IL-10, TNF-alpha
Matrix tested: Human plasma
Summary: The aim of this study was to investigate the proliferation and decay kinetics of specific subsets of CD4 and CD8 cells in HIV infection through in vivo BrdU labeling method. The kinetics parameters were further correlated with CD4 levels, viral load, and biomarkers of inflammation and microbial translocation.
|
| Stanton, M.C., Chen, S.C., Jackson, J.V., Rojas-Triana, A., Kinsley, D., Cui, L., Fine, J.S., Greenfeder, S., Bober, L.A., Jenh, C.H. (2011) Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice. J Inflamm. Vol. 8:8.
interleukin, IL6, IL10, IL12p70, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, Monocyte chemotactic protein-1, granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: GM-CSF, Insulin, Leptin, MCP-1, IL-6, TNF-alpha, IL-10, IL-12p70, IL-1beta, KC/GRO/CINC/CXCL1
Matrix tested: Mouse serum
Summary: This study investigated the molecular mechanisms underlying insulin resistance, hyperinsulinemia, and progression to liver steatosis and fibrosis in diet-induced obesity (DIO) mouse model.
|
| Tumani, H., Kassubek, J., Hijazi, M., Lehmensiek, V., Unrath, A., Sussmuth, S., Lauda, F., Kapfer, T., Fang, L., Senel, M., Brettschneider, J. (2011) Patterns of Th1/Th2 Cytokines Predict Clinical Response in Multiple Sclerosis Patients Treated with Glatiramer Acetate. Eur Neurol. Vol. 65(3):164-169. [Epub ahead of print].
Interleukin, IL2, IL4, IL10, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, multiple sclerosis, Glatiramer acetate
Analytes tested using MSD assays: IFN-gamma, IL-2, IL-4, IL-10, Osteopontin (OPN)
Matrix tested: Human serum
Summary: In this study, TH1 and TH2 cytokines were profiled in patients with remitting-relapsing multiple sclerosis in order to correlate their levels with response to glatiramer acetate treatment.
|
| Uldrick, T.S., Polizzotto, M.N., Aleman, K., O'Mahony, D., Wyvill, K.M., Wang, V., Marshall, V., Pittaluga, S., Steinberg, S.M., Tosato, G., Whitby, D., Little, R.F., Yarchoan, R. (2011) High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy. Blood. 2011 Apr 12. [Epub ahead of print].
Interferon, IFNg, IFN-g, IFN-?, IFN?, IFNgamma, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, IL12-p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha (MSD Human ProInflammatory 7-Plex)
Matrix tested: Human serum
Summary: This study evaluated the effectiveness of high dose of zidovudine/valganciclovir (AZT/VGC) in patients with symptomatic Kaposi Sarcoma Herpes virus (KSHV)-associated multicentric Castleman disease (KSHV-MCD). The aim was to target KSHV-MCD cells that highly express the lytic genes, ORF21 and ORF36.
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| Van Wagner, L.B., Koppe, S.W., Brunt, E.M., Gottstein, J., Gardikiotes, K., Green, R.M., Rinella, M.E. (2011) Pentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial. Ann Hepatol. Vol. 10(3):277-86.
IL6, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?, non-alcoholic fatty liver disease, obesity, cirrhosis
Analytes tested using MSD assays: IL-1beta, IL-6, TNF-alpha
Matrix tested: Human serum
Summary: This study examined the safety and tolerability of pentoxifylline in patients with obesity related liver disease such as non-alcoholic steatohepatitis. The effect on aminotransferases was investigated along with liver histology analysis.
|
| Watson, C.J., Ledwidge, M.T., Phelan, D., Collier, P., Byrne, J.C., Dunn, M.J., McDonald, K.M., Baugh, J.A. (2011) Proteomic analysis of coronary sinus serum reveals leucine-rich a2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure. Circ Heart Fail. Vol. 4(2):188-97.
Interleukin, IL6, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF?, TNF-?
Analytes tested using MSD assays: IL-6, TNF-alpha
Matrix tested: Human serum
Summary: In this study, coronary sinus sera from hypertensive individuals, classified by their high Brain Natriuretic Peptide (BNP) levels, were analyzed to determine biomarkers of ventricular dysfunction and heart failure.
|
| Wen, P.Y., Schiff, D., Cloughesy, T.F., Raizer, J.J., Laterra, J., Smitt, M., Wolf, M., Oliner, K.S., Anderson, A., Zhu, M., Loh, E., Reardon, D.A. (2011) A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro Oncol. [Epub ahead of print].
Hepatocyte growth factor receptor, HGF, scatter factor, phase 2 clinical trial
Analytes tested using MSD assays: Soluble c-Met
Matrix tested: Human plasma
Summary: This paper provides the results of safety and efficacy testing of AMG 102, a fully human monoclonal antibody that targets hepatocyte growth factor/scatter factor, in patients with glioblastoma.
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| Wong, Y., Sethu, C., Louafi, F., Hossain, P. (2011) Lipopolysaccharide Regulation of Toll-Like Receptor-4 and Matrix Metalloprotease-9 in Human Primary Corneal Fibroblast Cells. Invest Ophthalmol Vis Sci. 2011 Jan 10. [Epub ahead of print].
interferon, IFN-g, IFNg, IFN-?, IFN?, IFNgamma, granulocyte macrophage colony stimulating factor, interleukin, IL-1ß, IL1ß, IL1b, IL1beta, IL-1b, IL2, IL6, IL8, IL10, IL12p70, IL12-p70, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, TNFa, University of Southampton
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha (MSD Human ProInflammatory 9-Plex Tissue Culture Kit)
Matrix tested: Tissue culture supernatants
Summary: In this study, the effects of toll-like receptor-4 activation and the production of pro-inflammatory cytokines and MMPs were examined in association with immune response related to microbial keratitis.
|
| Yang, G., Marras, W.S., Best, T.M. (2011) The biochemical response to biomechanical tissue loading on the low back during physical work exposure. Clin Biomech (Bristol, Avon). Vol. 26(5):431-7. Epub 2011 Feb 23.
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, IL10, low back disorders
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, TNF-alpha (MSD Human ProInflammatory 4-Plex Panel II Kit), IL-10, Prostraglandin E2 (PGE2)
Matrix tested: Human plasma
Summary: This study investigated the biochemical response such as the production of inflammatory cytokines involved in physical work that stresses the lower back, and correlated the results with specific lumbar spine tissue loads.
|
| Zhu, A.X., Duda, D.G., Ancukiewicz, M., di Tomaso, E., Clark, J.W., Miksad, R., Fuchs, C.S., Ryan, D.P., Jain, R.K. (2011) Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value. Clin Cancer Res. Vol. 17(4):918-27. Epub 2010 Sep 15.
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-?, TNF?, IL6, IL8, vascular endothelial growth factor receptor, placental-derived growth factor, VEGFR-1, basic fibroblast growth factor, sorafenib
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, TNF-alpha, VEGF, soluble VEGFR1, bFGF, PlGF
Matrix tested: Human plasma
Summary: In this study, the toxicity profile of sunitinib therapy was characterized by evaluating the circulating biomarkers in a single-arm phase II investigation in hepatocellular carcinoma patients.
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| Altan, Z.M., Denis, D., Kagan, D., Grund, E.M., Palmer, S.S., Nataraja, S.G. (2010) A Long-Acting Tumor Necrosis Factor a-Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models of Endometriosis. J Pharmacol. Vol. 334(2): 460-466.
Interleukin, IL6, IL8, granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: GMCSF, IL-6, IL-8, MCP-1
Matrix tested: Cell culture medium
Summary: This study investigated the ability of a high affinity TNF-alpha inhibitor in reverting established lesions of endometriosis and its effectiveness in inhibiting TNF-alpha induced inflammatory cytokine expression.
|
| Andersson, U., Henriksson, E., Strom, K., Alenfall, J., Goransson, O., Holm, C. (2010) Rose hip exerts anti-diabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab. 2010 Oct 19. [Epub ahead of print].
Interleukin, IL6, glucose tolerance, cholesterol, polyphenol
Analytes tested using MSD assays: IL-6
Matrix tested: Mouse plasma
Summary: In this study, the beneficial metabolic effects of rose hip and the mechanisms underlying the anti-diabetic effects were investigated in a high-fat fed C57BL/6J mouse, a model for obesity, impaired glucose tolerance and early type 2 diabetes.
|
| Atzei, P., Gargan, S., Curran, N., Moynagh, P.N. (2010) Cactin Targets the MHC Class III Protein I{kappa}B-like (I{kappa}BL) and Inhibits NF-{kappa}B and Interferon-regulatory Factor Signaling Pathways. J Biol Chem. Vol. 285(47):36804-17.
Interferon, IFN-ß, IFNß, IFN-b, IFNb, IFNbeta
Analytes tested using MSD assays: IFN-beta
Matrix tested: Cell culture medium
Summary: In this study, the human ortholog of Cactin protein, a regulator of Toll signaling in Drosophila, has been functionally characterized with respect to its localization within the cell and regulation of innate immune signaling.
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| Ayanoglu, G., Desai, B., Fick, R.B. Jr., Grein, J., de Waal Malefyt, R., Mattson, J., McClanahan, T., Olmstead, S., Reece, S.P., Van Scott, M.R., Wardle, R.L. (2010) Modeling asthma in macaques: longitudinal changes in cellular and molecular markers. Eur Respir J. [Epub ahead of print].
Macrophage-derived chemokine, asthma, primate model, natural killer T cell lymphocyte, corticosteroid
Analytes tested using MSD assays: Eotaxin, MDC
Matrix tested: Cynomolgus monkey serum and bronchoalveolar lavage fluid
Summary: In this study, Cynomolgus macaques were tested as a model for human asthma by examining the chronic effects of aeroallergen exposure on immune and inflammatory parameters.
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| Batchelor, T.T., Duda, D.G., di Tomaso, E., Ancukiewicz, M., Plotkin, S.R., Gerstner, E., Eichler, A.F., Drappatz, J., Hochberg, F.H., Benner, T., Louis, D.N., Cohen, K.S., Chea, H., Exarhopoulos, A., Loeffler, J.S., Moses, M.A., Ivy, P., Sorensen, A.G., Wen, P.Y., Jain, R.K. (2010) Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. Vol. 28(17):2817-23.
Vascular endothelial growth factor, placental growth factor, basic fibroblast growth factor, interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, TGF, matrix metalloproteinase
Analytes tested using MSD assays: VEGF, PlGF, sVEGFR1, bFGF, IL-1beta, IL-6, IL-8, transforming growth factor, MMP-2, MMP-10
Matrix tested: Human plasma
Summary: This study reports the clinical efficacy, toxicity, and biomarker data from the phase II clinical trial of cedarinib in patients with recurrent glioblastoma.
|
| Bose, C., Laughon, M., Allred, E.N., Van Marter, L.J., O'shea, T.M., Ehrenkranz, R.A., Fichorova, R., Leviton, A; for the ELGAN Study Investigators. (2010) Blood protein concentrations in the first two postnatal weeks that predict bronchopulmonary dysplasia among infants born before the 28th week of gestation. Pediatr Res. 2010 Dec 9. [Epub ahead of print].
CXCL8, CCL2, CCL13, macrophage inflammatory protein 1, CCL4, regulated upon activation, normal T cell expressed and secreted, CCL5, interferon inducible T cell chemoattractant, CXCL11, CD54, CD50, CD106, E-SEL, CD62E, MMP1, MMP9, C reactive protein, SAA, matrix metalloproteinase, myeloperoxidase, vascular endothelial growth factor, VEGFR1, VEGFR2, IGF-BP1, insulin-like growth factor binding protein, Vascular cell adhesion protein 1, serum amyloid A, Inter-Cellular Adhesion Molecule 1, interleukin, IL-1ß, IL1ß, IL1b, IL1beta, IL-1b, IL6, IL6 receptor, IL6R, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, TNFa, TNFR1, TNFR2, IL8, Monocyte chemotactic protein-1, EGLAN, University of North Carolina
Analytes tested using MSD assays: IL-1beta, IL-6, IL-6R, TNF-alpha, TNF-R1, TNF-R2, IL-8, MCP-1, MCP-4, MIP-1beta, RANTES, I-TAC, ICAM-1, ICAM-3, VCAM-1, E-selectin, MMP-1, MMP-9, CRP, SAA, MPO, VEGF, VEGF-R1, VEGF-R2, IGF-BP-1
Matrix tested: Dried blood spots
Summary: This study evaluated the role of inflammation in the development of bronchopulmonary dysplasia in extremely low gestational age newborns by measuring the levels of biomarkers present in neonatal blood samples and analyzing their association with pulmonary inflammation. |
| Bourghardt, J., Wilhelmson, A.S., Alexanderson, C., De Gendt, K., Verhoeven, G., Krettek, A., Ohlsson, C., Tivesten, A. (2010) Androgen Receptor-Dependent and Independent Atheroprotection by Testosterone in Male Mice. Endocrinology. 2010 Sep 22. [Epub ahead of print].
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL6, IL10, IL12p70, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, GROalpha, CXCL1, growth regulated protein, keratinocyte-derived chemokine
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC/GRO/CINC, TNF-alpha (MSD Mouse ProInflammatory 7-Plex)
Matrix tested: Mouse serum
Summary: The aim of this study was to investigate the role of androgen receptor pathway in atheroprotection by testosterone by analyzing the effects of testosterone in AR knockout mice.
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| Burke, R.L., West, M.W., Erwin-Cohen, R., Selby, E.B., Fisher, D.E., Twenhafel, N.A. (2010) Alterations in Cytokines and Effects of Dexamethasone Immunosuppression during Subclinical Infections of Invasive Klebsiella pneumoniae with Hypermucoviscosity Phenotype in Rhesus (Macaca mulatta) and Cynomolgus (Macaca fascicularis) Macaques. Comp Med. Vol. 60(1): 62–70.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL2, IL6, IL8, IL10, IL12p70, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8,IL-10, IL-12p70, TNF-alpha
Matrix tested: Cynomolgus monkey serum
Summary: This study is based on the elucidation of the pathophysiology of hypermucoviscosity phenotype (HMV) K. pneumoniae is in macaques by analysis of cytokine levels as an indication of altered immune status in sub-clinically infected macaques.
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| Chapman, J., Miles, P.D., Ofrecio, J.M., Neels, J.G., Yu, J.G., Resnik, J.L., Wilkes, J., Talukdar, S., Thapar, D., Johnson, K., Sears, D.D. (2010) Osteopontin Is Required for the Early Onset of High Fat Diet-Induced Insulin Resistance in Mice. PLoS ONE Vol. 5(11): e13959.
Keratinocyte-derived chemokine, growth-related oncogene, Interferon, IFNgamma, IFN—g, IFNg, IFN-?, IFN?, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL10, IL12p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, PI3-kinase
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC/GRO/CINC (CXCL1), TNF-alpha (Mouse ProInflammatory 7-Plex panel), Phospho (Ser473) Akt, Total Akt
Matrix tested: Mouse plasma and tissue lysates
Summary: The focus of this study was to examine the role of Osteopontin in diet-induced insulin resistance by comparing wild type and osteopontin-knockout mice that were fed with normal chow or high fat diet followed by biomarker analysis.
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| Chapman, R.W., Curran, A.K., House, A., Richard, J., Salisbury, B., Hunter, J.C., Anthes, J.C., Phillips, J.E. (2010) Effect of mometasone furoate (MF)/formoterol fumarate (F) combination (MF/F) on late-phase responses in allergen-challenged Brown Norway rats. Pulm Pharmacol Ther. 2010 Oct 13. [Epub ahead of print]
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL4, IL5, IL13, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, Interferon, IFN-?, IFN?, IFN-g, IFNg, IFNgamma, Keratinocyte-derived chemokine, growth-related oncogene
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, IL-5, IL-13, KC/GRO/CINC (CXCL1), TNF-alpha (MSD Rat Demonstration 7-Plex Ultra-Sensitive Kit)
Matrix tested: Rat bronchoalveolar lavage fluid (BALF)
Summary: The focus of this study was to test the effects of a corticosteroid/ß2-adrenergic receptor agonist combination on late phase response to antigen challenge in a rat model sensitized by ovalbumin.
|
| Chiang, P.C., Hu, Y., Blom, J.D., Thompson, D.C. (2010) Evaluating the Suitability of Using Rat Models for Preclinical Efficacy and Side Effects with Inhaled Corticosteroids Nanosuspension Formulations. Nanoscale Research Letters. Vol. 5(6): 1010-1019.
nanosuspension formulation, TNFalpha, TNF-a, TNFa, TNFa, TNF-a, tumor necrosis factor, chronic obstructive pulmonary disease, COPD, asthma
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Rat plasma
Summary: The focus of this study was to test the possibility of evaluating the efficacy and side effects of anti-inflammatory drugs such as fluticasone and ciclesonide in the popular acute rat LPS model.
|
| Coad, M., Clifford, D., Rhodes, S.G., Hewinson, R.G., Vordermeier, H.M., Whelan, A.O. (2010) Repeat tuberculin skin testing leads to desensitisation in naturally infected tuberculous cattle which is associated with elevated interleukin-10 and decreased interleukin-1 beta responses. Vet Res. Vol. 41(2):14.
IL10, Interleukin, whole blood, Veterinary Laboratories Agency, IFN-g, IFNg, interferon, IL-1ß, IL1ß, IL1beta, IL4, IL12, MIP1beta, MIP1ß, MIP1b, MIP-1ß, MIP-1b, tumor necrosis factor, TNF-a, TNFa, TNFalpha, TNF-a, TNFa
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, IL-10, IL-12, MIP-1beta and TNF-alpha
Matrix tested: antigen stimulated bovine whole blood cultures on custom bovine 7-plex panel
Summary: This paper is based on a study conducted by VLA to study the diagnostic and immunological consequences of repeated skin tests in cattle infected with Mycobacterium bovis.
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| Collington, S.J., Hallgren, J., Pease, J.E., Jones, T.G., Rollins, B.J., Westwick, J., Austen, K.F., Williams, T.J., Gurish, M.F., Weller, C.L. (2010) The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo. J Immunol. Vol. 184(11):6114-23.
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, TNFalpha, TNF-a, TNFa, TNFa, TNF-a, tumor necrosis factor, IL2, IL4, IL5, IL10, IL12, KC, GRO, MCP-1, Monocyte chemotactic protein 1
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-10, IL-12, CXCL1, TNF-alpha, CCL2
Matrix tested: Mouse bronchoalveolar lavage fluid (BALF)
Summary: This study conducted an in vitro analysis of the chemotactic effect of CCL2 on bone marrow-derived mast cell progenitors and tested whether the CCR2 expression by mast cell progenitors was directly involved in their antigen-induced pulmonary recruitment.
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| Cronin, M., Morrissey, D., Rajendran, S., El Mashad, S.M., van Sinderen, D., O'Sullivan, G.C., Tangney, M. (2010) Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors. Mol Ther. Vol. 18(7):1397-407.
interferon, IFNgamma, IFNg, IFN-g, IFN-?, IFN?, interleukin, IL1beta, IL1b, IL-1b, IL-1ß, IL1ß, IL6, IL12p70, IL10, KC, GRO, CXCL1, keratinocyte derived chemokine, IL8, tumor necrosis factor alpha, TNFa, TNF-a, TNFalpha, TNF-a, TNFa
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, TNF-alpha, KC/GRO
Matrix tested: Mouse serum and gastro-instestinal tract lysates (GIT)
Summary: This paper demonstrated the translocation, homing and growth of a non-pathogenic strain of Bifidobacterium breve containing a plasmid expressing the lux luminescence-based tagging system, in a murine model following intravenous administration.
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| Crotta, S., Brazzoli, M., Piccioli, D., Valiante, N.M., Wack, A. (2010) Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection. J Hepatol. Vol. 52(2):183-90.
IL8, Interleukin, Interferon, IFN, IFNgamma, IFNg, IFN-g, IFN-g, IFNg, natural killer cells
Analytes tested using MSD assays: IFN-gamma, IL-8
Matrix tested: Human NK cell culture supernatants
Summary: This paper investigates whether Hepatitis C viral infection affects activation of natural killer cells and the impact of altered NK cell activation on the overall infectivity of the virus.
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| Dangardt, F., Osika, W., Chen, Y., Nilsson, U., Gan, L.M., Gronowitz, E., Strandvik, B., Friberg, P. (2010) Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents. Atherosclerosis. Vol. 212(2):580-5.
Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL10, IL12p70, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, PI3-kinase, IL2, IL6, IL8, IL10, IL12p70, inter-cellular adhesion molecule-1, vascular cell adhesion molecule-1, granulocyte monocyte colony stimulating factor, obesity
Analytes tested using MSD assays: C-reactive Protein (CRP), GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha, soluble ICAM, soluble VCAM, serum amyloid A (SAA)
Matrix tested: Human serum
Summary: The aim of this study was to investigate the effect of n-3 supplementation (omega-3 polyunsaturated fatty acid) on vascular function and inflammation of the vascular endothelium in obese individuals.
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| Davis, J.M. 3rd, Knutson, K.L., Strausbauch, M.A., Crowson, C.S., Therneau, T.M., Wettstein, P.J., Matteson, E.L., Gabriel, S.E. (2010) Analysis of complex biomarkers for human immune-mediated disorders based on cytokine responsiveness of peripheral blood cells. J Immunol. Vol. 184(12):7297-304.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL5, IL6, IL7, IL8, IL10, IL12, IL13, IL17A, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, Macrophage inflammatory protein 1 beta, Monocyte chemotactic protein 1, Granulocyte colony stimulating factor, Granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17A, IFN-gamma, TNF-alpha, MCP-1, MIP-1beta, G-CSF, GM-CSF
Matrix tested: Peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: The aim of this study was to demonstrate that multiplexed analysis of cytokine response could identify an immunologic signature that can differentiate patients with early and late rheumatoid arthritis from controls.
|
| Docena, G., Rovedatti, L., Kruidenier, L., Fanning, A., Leakey, N.A., Knowles, C.H., Lee, K., Shanahan, F., Nally, K., McLean, P.G., Di Sabatino, A., MacDonald, T.T. (2010) Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease. Clin Exp Immunol. Vol. 162(1):108-15.
Interleukin, IL6, Crohn's disease, Ulcerative colitis, irritable bowel disorder, IBD, p38a, p38alpha
Analytes tested using MSD assays: IL-6
Matrix tested: Lamina propria mononuclear cell (LPMC) culture supernatants, colon biopsy tissues
Summary: This study investigated whether the p38 MAPK pathway is triggered in inflammatory bowel disease (IBD) and to test the effect of different p38-alpha inhibitors on MAPK phosphorylation and cytokine production in gut samples from IBD patients.
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| Donato, K.A., Gareau, M.G., Wang, Y.J., Sherman, P.M. (2010) Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumor necrosis factor-{alpha}-induced barrier dysfunction and pro-inflammatory signalling. Microbiology. [Epub ahead of print].
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL5, IL6, IL7, IL8, IL10, IL12, IL13, IL17A, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, Macrophage inflammatory protein 1 beta, Monocyte chemotactic protein 1, Granulocyte colony stimulating factor, Granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: Eotaxin-1, IL-8, IP-10, MCP-1, MCP-4, MIP-1beta, TARC
Matrix tested: Cell culture supernatants
Summary: The aim of this paper was to elucidate the mechanism by which probiotics, such as Lactobacillus rhamnosus GG, prevents the deleterious effects on tight junction structures induced by pro-inflammatory cytokines. Disruption of tight junctions can cause various intestinal disorders ranging from acute infectious diarrhoea to chronic inflammatory bowel disease.
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| Duner, P., To, F., Berg, K., Alm, R., Björkbacka, H., Engelbertsen, D., Fredrikson, G.N., Nilsson, J., Bengtsson, E. (2010) Immune responses against aldehyde-modified laminin accelerate atherosclerosis in Apoe-/- mice. Atherosclerosis. Vol. 212(2):457-65.
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL5, IL10, IL12, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, Interferon, IFN-?, IFN?, IFN-g, IFNg, IFNgamma, Keratinocyte-derived chemokine, growth-related oncogene
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC/GRO/CINC (CXCL1), IL-10, IL-12 total, TNF-alpha (MSD Mouse TH1/TH2 9-Plex Panel)
Matrix tested: Mouse plasma
Summary: The aim of this paper was to elucidate the mechanism by which probiotics, such as Lactobacillus rhamnosus GG, prevents the deleterious effects on tight junction structures induced by pro-inflammatory cytokines. Disruption of tight junctions can cause various intestinal disorders ranging from acute infectious diarrhoea to chronic inflammatory bowel disease.
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| Eda, H., Zhang, J., Keith, R.H., Michener, M., Beidler, D.R., Monahan, J.B. (2010) Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood. Cytokine. 2010 Sep 7. [Epub ahead of print].
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, IL10, IL12p70, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, Macrophage inflammatory protein, MIP1beta, MIP-1b, MIP1b, MIP-1ß, MIP1ß, Thymus Activation Regulated Chemokine, interferon gamma inducible protein, Monocyte chemotactic protein, MCP1, MCP4, Granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: G-CSF, GM-CSF, IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, TNF-alpha, Eotaxin, MIP-1beta, TARC, IP-10, IL-8, MCP-1, MCP-4
Matrix tested: Human plasma
Summary: This study examined whether cytokines and chemokines are induced by M-CSF and IL-34 in an ex vivo assay using human whole blood in order to determine the role of M-CSF and IL-34 in induction of proinflammatory molecules. The effect of soluble M-CSF receptor and cFMS kinase inhibitors were also tested.
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| Fang, L., Teuchert, M., Huber-Abel, F., Schattauer, D., Hendrich, C., Dorst, J., Zettlmeissel, H., Wlaschek, M., Scharffetter-Kochanek, K., Kapfer, T., Tumani, H., Ludolph, A.C., Brettschneider, J. (2010) MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS. J Neurol Sci. Vol. 294(1-2):51-6. Epub 2010 May 4.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, Matrix metalloproteinases, transgenic SOD1(G93A) mice
Analytes tested using MSD assays: IL-1beta, TNF-alpha
Matrix tested: Mouse spinal cord and skin homogenates
Summary: The aim of this study was to test whether gelatinase MMPs such as MMP-2 and MMP-9 are a probable link between neurodegeneration and skin pathology in cases of with amyotrophic lateral sclerosis. The mechanisms affecting MMP in ALS were tested by determining the relation of MMP to markers of oxidative stress and inflammatory cytokines.
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| Ford, E.S., Greenwald, J.H., Richterman, A.G., Rupert, A., Dutcher, L., Badralmaa, Y., Natarajan, V., Rehm, C., Hadigan, C., Sereti, I. (2010) Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection. AIDS. Vol. 24(10):1509-17.
granulocyte macrophage colony stimulating factor, interferon, IFNgamma, IFNg, IFN-g, IFN-?, IFN?, interleukin, IL1beta, IL1b, IL-1b, IL-1ß, IL1ß, IL10, IL12p70, IL2, IL6, IL8, tumor necrosis factor alpha, TNFa, TNF-a, TNFalpha, TNF-a, TNFa, eotaxin, eotaxin-3, interferon gamma induced protein, monocyte chemotactic protein, MCP1, MCP4, macrophage derived chemokine, macrophage inflammatory protein 1 beta, thymus and activation regulated chemokine, serum amyloid A, vascular cellular adhesion molecule 1, C-reactive protein, Inter Cellular Adhesion Molecule 1, myeloperoxidase, tissue inhibitor of metalloproteinase 1, tumor necrosis factor receptor II, adiponectin
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-1, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha, eotaxin, eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1beta, TARC, serum amyloid A, VCAM-1, ICAM-1, CRP, MPO, TIMP-1, TNF-RII, adiponectin
Matrix tested: Human serum
Summary: This study evaluated the traditional risk factors and markers of inflammation and cell activation in HIV-infected individuals prior to an incident CVD event to investigate the potential shared and unique CVD risk factors that exist within the HIV-infected population.
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| Fu, Q., Zhu, J., Van Eyk, J.E. (2010) Comparison of Multiplex Immunoassay Platforms. Clinical Chemistry. Vol. 56(2):314-318.
IL1b, IL1beta, IL-1b, IL1-b, Interleukin, IL2, IL6, IL10, IL12p70, IL12-p70, IL-12(p70)
Analytes tested using MSD assays: IL-1beta, IL-2, IL-6, IL-10, IL-12p70
Matrix tested: Human serum
Summary: In this paper, five different multiplex immunoassays were compared for reproducibility, robustness, accuracy and throughput (MESO SCALE DISCOVERY® technology, FAST Quant, A2 from Beckman Coulter, Bio-Plex from Bio-Rad, FlowCytomix from Bender MedSystems).
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| Gadjeva, M., Nagashima, J., Zaidi, T., Mitchell, R.A., Pier, G.B. (2010) Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis. PLoS Pathog. Vol. 6(3):e1000826.
IL10, Interleukin, IFN-?, IFN?, interferon, IFNg, IFN-g, IFNgamma, IL-1ß, IL1ß, IL1beta, IL-1b, IL1b, IL6, IL12p70
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC/GRO/CXCL1
Matrix tested: Mouse corneal lysates
Summary: This study was focused on investigating whether inhibition of migration inhibitory factor (MIF) in the eye leads to a decrease in P. aeruginosa induced pathology, and the role of MIF in polymorphonuclear leukocyte infiltration and inflammation in the infection.
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| Gadjeva, M., Paradis-Bleau, C., Priebe, G.P., Fichorova, R., Pier, G.B. (2010) Caveolin-1 modifies the immunity to Pseudomonas aeruginosa. J Immunol. Vol. 184(1):296-302.
IL1b, IL1beta, IL-1b, IL1-b, Interleukin, IL2, IL6, IL10, IL12p70, IL12-p70, IL-12(p70), Macrophage migration inhibitory factor
Analytes tested using MSD assays: IL-1beta, IL-6, IL-12p70, IL-10, IFN-gamma, KC / CXCL1 / GRO
Matrix tested: Bronchoalveolar lavage fluid (BALF)
Summary: In this paper, the role of Caveolin-1 in acute and chronic P. aeruginosa infection was tested in a cav1 knockout mouse model.
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| Gordon, M.S., Sweeney, C.S., Mendelson, D.S., Eckhardt, S.G., Anderson, A., Beaupre, D.M., Branstetter, D., Burgess, T.L., Coxon, A., Deng, H., Kaplan-Lefko, P., Leitch, I.M., Oliner, K.S., Yan, L., Zhu, M., Gore, L. (2010) Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors. Clin Cancer Res. Vol. 16(2):699-710.
Hepatocyte growth factor, scatter factor, cMet
Analytes tested using MSD assays: Soluble c-Met
Matrix tested: Human plasma
Summary: Safety, anti-AMG 102 antibody formation, pharmacokinetics, tumor response, and exploratory biomarkers were assessed in patients with refractory advanced solid tumors.
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| Gouin, J.P., Carter, C.S., Pournajafi-Nazarloo, H., Glaser, R., Malarkey, W.B., Loving, T.J., Stowell, J., Kiecolt-Glaser, J.K. (2010) Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology. [Epub ahead of print].
Interleukin, IL6, Tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNF-a, TNFa, Oxytocin, Vasopressin
Analytes tested using MSD assays: IL-6, TNF-alpha
Matrix tested: Human plasma
Summary: In this study, the relationships between marital behavior and endogenous oxytocin and vasopressin were examined to determine the extent to which these peptides modulate proinflammatory cytokine production and wound healing, and to evaluate the characteristics of individuals with the highest neuropeptide levels.
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| Guo, Y., Hill, A.A., Ramsey, R.C., Immermann, F.W., Corcoran, C., Young, D., Lavallie, E.R., Ryan, M., Bouchard, T., Pfeifer, R., Warner, G., Bologna, M., Bloom, L., O'Toole, M. (2010) Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody. J Transl Med. Vol. 8(1):50.
IL10, Interleukin, IFN-?, IFN?, interferon, IFNg, IFN-g, IFNgamma, IL-1ß, IL1ß, IL1beta, IL-1b, IL1b, IL6, IL12p70
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL13, TNF-alpha (MSD Human TH1/TH2 10-Plex Kit), IL-6, CCL3
Matrix tested: Human peripheral blood mononuclear cell (PBMC) supernatants
Summary: Antibody Ab-01 is an immune system antagonist that inhibits IL-21 mediated cell activation. This study was conducted to detect any immune system activation signals induced by in vitro by cross-linked Ab-01 or in vivo in Cynomolgus monkeys. Efforts were made to force an agonistic signal so that potential risks for immunotoxicity were thoroughly assessed.
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| Haidl, I.D., McAlpine, S.M., Marshall, J.S. (2010) Enhancement of Mast Cell IL-6 Production by Combined Toll-Like and Nucleotide-Binding Oligomerization Domain-Like Receptor Activation. Int Arch Allergy Immunol. Vol. 154(3):227-235. [Epub ahead of print].
Interleukin, IL4, IL5, IL10, IL12p70, IL13, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, Peptidoglycan, Leukotrienes, allergy, Pattern recognition receptors
Analytes tested using MSD assays: IFN-gamma, IL-4, IL-5, IL-10, IL-12p70, IL-13
Matrix tested: Cell culture medium
Summary: The aim of this study was to characterize the mediators produced by mast cells in response to bacterial products such as peptidoglycan and lipopeptides. The effect of combining Toll-like receptor and nucleotide-binding oligomerization domain-like receptor agonists on mast cell mediator production was also addressed.
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| Hallberg, L., Janelidze, S., Engstrom, G., Wisen, A.G., Westrin, A., Brundin, L. (2010) Exercise-induced release of cytokines in patients with major depressive disorder. J Affect Disord. Vol. 126(1-2):262-7. Epub 2010 Mar 27.
soluble vascular cell adhesion molecule, Interleukin, inter-cellular adhesion molecule, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL-5, IL6, IL8, IL10, IL12, IL13, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, MDD
Analytes tested using MSD assays: Serum amyloid A (SAA), IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, TNF-alpha, soluble VCAM, soluble ICAM, C reactive protein (CRP)
Matrix tested: Human plasma
Summary: This study examined inflammatory factors in response to exercise to test whether muscular tissue is responsible for alterations in cytokine levels associated with major depressive disorder.
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| Hecht, J.L., Fichorova, R.N., Tang, V.F., Allred, E.N., McElrath, T.F., Leviton, A; for the ELGAN study investigators. (2010) The relationship between neonatal blood protein profiles and placenta histologic characteristics in extremely low gestation age newborns. Pediatr Res. 2010 Oct 1. [Epub ahead of print]
C-Reactive Protein, serum amyloid A, myeloperoxidase, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, Interleukin-6 Receptor, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, Tumor Necrosis Factor Receptor, TNFR1, TNFR2, Monocyte Chemotactic Protein, Macrophage Inflammatory Protein, MIP-1b, MIP1b, Regulated upon Activation, Normal T-cell Expressed, and Secreted, Intercellular Adhesion Molecule, ICAM1, ICAM3, Vascular Cell Adhesion Molecule, Matrix Metalloproteinase, Vascular Endothelial Growth Factor Receptor, KDR, Flt-1, Insulin Growth Factor Binding Protein-1, Interferon-inducible T cell Alpha-Chemoattractant
Analytes tested using MSD assays: CRP, SAA, MPO, IL-1beta, IL-6, IL-6R, TNF-alpha, TNF-R1, TNF-R2, IL-8, MCP-1, MCP-4, MIP-1beta, RANTES, IGFBP-1, ITAC, ICAM-1, ICAM-3, E-selectin, VCAM-1, MMP-1, MMP-9, VEGF, VEGF-R1, VEGF-R2
Matrix tested: Elution from dried blood spots
Summary: In this study, a broad range of inflammatory biomarkers were measured in the blood of 871 infants born before 28th week of gestation to determine the relationship between the levels of these proteins with placental inflammation.
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| Huber, J.P., Ramos, H.J., Gill, M.A., Farrar, J.D. (2010) Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3. J Immunol. 2010 Jun 16. [Epub ahead of print].
asthma, atopy
Analytes tested using MSD assays: Cytokines
Matrix tested: Cell culture supernatants
Summary: This paper examined the role of IFN-a/ß in regulating human Th2 development and established that IFN-a/ß blocked Th2 cytokine secretion through the inhibition of transcription factor, GATA3, during Th2 development and in fully committed Th2 cells.
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| Igawa, T., Ishii, S., Tachibana, T., Maeda, A., Higuchi, Y., Shimaoka, S., Moriyama, C., Watanabe, T., Takubo, R., Doi, Y., Wakabayashi, T., Hayasaka, A., Kadono, S., Miyazaki, T., Haraya, K., Sekimori, Y., Kojima, T., Nabuchi, Y., Aso, Y., Kawabe, Y., Hattori, K. (2010) Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization. Nat Biotechnol. Vol. 28(11):1203-7.
IL-6 receptor
Analytes tested using MSD assays: Human soluble IL-6R
Matrix tested: Mouse plasma
Summary: The focus of this study was to engineer pH dependent ligand binding into tocilizumab, an antibody against IL-6 receptor, so that it binds to IL-6R in the neutral pH of plasma and gets dissociated from it in the acidic endosome. The overall aim was to increase recycling of the antibody and reduce its clearance from the system.
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| Inacio, A.R., Ruscher, K., Leng, L., Bucala, R., Deierborg, T. (2010) Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke. J Cereb Blood Flow Metab. 2010 Nov 10. [Epub ahead of print].
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, experimental stroke, MIF, parvalbumin
Analytes tested using MSD assays: IL-1beta
Matrix tested: Mouse brain lysates, mouse serum
Summary: The focus of this study was to study the contribution of migration inhibitory factor (MIF) to neuronal cell death and to the development of neurologic deficits after transient middle cerebral artery occlusion.
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| Janelidze, S., Mattei, D., Westrin, S., Träskman-Bendz, L., Brundin, L. (2010) Cytokine levels in the blood may distinguish suicide attempters from depressed patients. Brain Behav Immun. 2010 Oct 15. [Epub ahead of print].
Interleukin, IL2, IL6, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, inflammation
Analytes tested using MSD assays: IL-2, IL-6, TNF-alpha
Matrix tested: Human plasma
Summary: In this study, levels of different cytokines were measured in suicidal and non-suicidal depressed patients as well as healthy controls to determine if peripheral inflammation is associated with a specific group of depressive patients.
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| Janot-Sardet, C., Assouline, B., Cheynier, R., Morre, M., Beq, S. (2010) A validated assay to measure soluble IL-7 receptor shows minimal impact of IL-7 treatment. J Immunol Methods. Vol. 353(1-2):115-23.
Interleukin, IL-7, IL7, HIV, simian
Analytes tested using MSD assays: Customer developed assay for soluble CD127
Matrix tested: Human plasma from normal and HIV-infected patients, Rhesus plasma, Cynomolgus plasma
Summary: In this paper, the development of a validated assay for the measurement of soluble IL-7 receptor alpha chain (CD127) in human and simian plasma using MSD technology has been described.
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| Jones, G.J., Pirson, C., Hewinson, R.G., Vordermeier, H.M. (2010) Simultaneous measurement of antigen-stimulated interleukin-1 beta and gamma interferon production enhances test sensitivity for the detection of Mycobacterium bovis infection in cattle. Clin Vaccine Immunol. Vol. 17(12):1946-51.
Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL4, IL10, IL12, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, macrophage inflammatory protein 1 beta, MIP1beta, MIP1ß, MIP-1ß, MIP1b, MIP-1b, tuberculosis
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, IL-10, IL-12, MIP-1beta, TNF-alpha
Matrix tested: Supernatants from whole blood culture
Summary: In this study, MSD multiplex assays were used to compare the levels of several cytokines between TB reactor animals (an animal that has failed the tuberculin test) and healthy controls. The aim was to identify new analytes that can be used as diagnostic test for bovine TB.
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| Jorde, R., Sneve, M., Torjesen, P.A., Figenschau, Y., Gøransson, L.G., Omdal, R. (2010) No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects. Cytokine. Vol. 50(2):175-80.
Interleukin, intercellular adhesion molecule-1, monocyte chemotactic protein-1, IL2, IL4, IL5, IL10, IL12, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, IL17, ICAM1, MCP1
Analytes tested using MSD assays: TH1/TH2 7-plex (IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IFN-gamma), IL-17, ICAM-1, MCP-1
Matrix tested: Human serum
Summary: In this paper, the effect of serum levels of vitamin D on cytokines and inflammation markers was tested in 437 overweight subjects with and without supplementation of the vitamin.
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| Khamri, W., Walker, M.M., Clark, P., Atherton, J.C., Thursz, M.R., Bamford, K.B., Lechler, R.I., Lombardi, G. (2010) Helicobacter pylori Stimulates Dendritic Cells to Induce IL-17 Expression From CD4+ T lymphocytes. Infect Immun. Vol. 78(2):845-53.
IL-1b, IL-1ß, IL1ß, IL1beta, Interleukin
Analytes tested using MSD assays: IL-1beta
Matrix tested: Human Peripheral blood mononuclear cell (PBMC) supernatants
Summary: In this paper, the role of dendritic cells in the induction of immune responses to Helicobacter pylori infection has been studied.
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| Knothe, S., Mutschler, V., Rochlitzer, S., Winkler, C., Ebensen, T., Guzman, C.A., Hohlfeld, J., Braun, A., Muller, M. (2010) Local treatment with BPPcysMPEG reduces allergic airway inflammation in sensitized mice BPPcysMPEG reduces airway inflammation. Immunobiology. Epub ahead of print.
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, TNFalpha, TNF-a, TNFa, TNFa, TNF-a, tumor necrosis factor, IL2, IL4, IL5, IL8, IL10, IL12, IL12p70, IL13, KC, GRO, Interferon, TFNgamma, IFN-g, IFNg, IFN?, IFN-?
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha, KC/GRO/CINC, IL-12 total (Human TH1/TH2 10-Plex and Mouse TH1/TH2 9-Plex)
Matrix tested: Cell culture supernatants, mouse bronchoalveolar lavage fluid (BALF)
Summary: The focus of this study was to evaluate the efficacy of BPPcysMPEG, a Toll like receptor agonist, to modulate antigen presenting cells and subsequent immune response in a human in vitro allergy model as well as in vivo in a mouse model.
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| Kolbus, D., Ramos, O.H., Berg, K.E., Persson, J., Wigren, M., Bjorkbacka, H., Fredrikson, G.N., Nilsson, J. (2010) CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe-/- mice. BMC Immunology. Vol. 11:58.
Interleukin, IL4, IL10, Interferon, IFN-?, IFN?, IFN-g, IFNg, IFNgamma
Analytes tested using MSD assays: IFN-gamma, IL-4, IL-10
Matrix tested: Cell culture supernatants
Summary: The focus of this study was to elucidate the immune response and the main pathways that are activated by hypercholesterolemia in relation to the development of atherosclerosis.
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| Kwon, B.K., Stammers, A.M., Belanger, L.M., Bernardo, A., Chan, D., Bishop, C.M., Slobogean, G.P., Zhang, H., Umedaly, H., Giffin, M., Street, J., Boyd, M.C., Paquette, S.J., Fisher, C.G., Dvorak, M.F. (2010) Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. J Neurotrauma. Vol. 27(4):669-82.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, traumatic spinal cord injury, clinical trial
Analytes tested using MSD assays: IL-1beta, TNF-alpha
Matrix tested: Human cerebrospinal fluid (CSF)
Summary: This study involved the measurement of inflammatory cytokines and neural tissue markers to elucidate the temporal pattern of protein expression involved in spinal cord injury and tested whether the levels of these biomarkers can be correlated with injury severity.
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| Lazar-Molnar, E., Chen, B., Sweeney, K.A., Wang, E.J., Liu, W., Lin, J., Porcelli, S.A., Almo, S.C., Nathenson, S.G., Jacobs, W.R. Jr. (2010) Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis. Proc Natl Acad Sci U S A. Vol. 107(30):13402-7.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL6, IL10, IL12p70, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, KC, GRO, CINC
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC/GRO/CINC, TNF-alpha (MSD Mouse Pro-Inflammatory 7-Plex Ultra-Sensitive Kit)
Matrix tested: Mouse serum and lung lysates
Summary: In this study, the role of programmed death-1 (PD-1) costimulatory receptor was tested in infection with Mycobacterium tuberculosis using a mouse model. PD-1 receptor inhibits T and B-cell activation by binding to its ligands.
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| Leviton, A., Fichorova, R., Yamamoto, Y., Allred, E.N., Dammann, O., Hecht, J., Kuban, K., McElrath, T., O'Shea, T.M., Paneth, N. (2010) Inflammation-related proteins in the blood of extremely low gestational age newborns. The contribution of inflammation to the appearance of developmental regulation. Cytokine. Vol. 53(1):66-73.
C-Reactive Protein, serum amyloid A, myeloperoxidase, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL6, IL8, Interleukin-6 Receptor, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, Tumor Necrosis Factor Receptor, TNFR1, TNFR2, Monocyte Chemotactic Protein, Macrophage Inflammatory Protein, MIP-1b, MIP1b, Regulated upon Activation, Normal T-cell Expressed, and Secreted, Intercellular Adhesion Molecule, ICAM1, ICAM3, Vascular Cell Adhesion Molecule, Matrix Metalloproteinase, Vascular Endothelial Growth Factor Receptor, KDR, Flt-1
Analytes tested using MSD assays: CRP, SAA, MPO, IL-1beta, IL-6, IL-6R, TNF-alpha, TNF-R1, TNF-R2, IL-8, MCP-1, MIP-1beta, RANTES, ICAM-1, ICAM-3, E-selectin, VCAM-1, MMP-1, MMP-9, VEGF, VEGF-R1, VEGF-R2
Matrix tested: Elution from dried blood spots
Summary: This study investigated the extent to which developmental regulation is apparent in the gestational age of 23-27 weeks and 6 days, by measuring circulating proteins in the blood of 818 children born before 28th week of gestation. The effect of placental inflammation on the levels of these proteins was also determined.
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| Li, P., Lu, M., Nguyen, M.T., Bae, E., Chapman, J., Feng, D., Hawkins, M., Pessin, J.E., Sears, D.D., Nguyen, A.K., Amidi, A., Watkins, S.M., Nguyen, U., Olefsky, J.M. (2010) Functional heterogeneity of CD11C positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. Vol. 285(20):15333-45.
Interleukin, IL6, IL10, IL12p70, GRO / CXCL1, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a
Analytes tested using MSD assays: IL-12p70, IFN-gamma, IL-6, IL-10, KC and TNF-alpha
Matrix tested: Mouse Epididymal White Adipose Tissue lysates
Summary: In this paper, the number of CD11c positive Adipose Tissue Macrophages and their phenotype was studied in insulin sensitive mice after a diet change.
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| Li, Y., Vijayanathan, V., Gulinello, M., Cole, P.D. (2010) Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine. Pharmacol Biochem Behav. Vol. 95(4):428-33.
CSF, Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL6, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, Acute lymphoblastic leukemia, Intrathecal injection, Folate, Homocysteine
Analytes tested using MSD assays: IL-1beta, IL-6, TNF-alpha
Matrix tested: Rat cerebrospinal fluid
Summary: This paper investigated the detrimental effects of methotrexate in contributing towards treatment induced cognitive dysfunction in patients with acute lymphoblastic leukemia. Methotrexate is a folic acid analog used as a chemotherapeutic agent.
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| Marchlik, E., Thakker, P., Carlson, T., Jiang, Z., Ryan, M., Marusic, S., Goutagny, N., Kuang, W., Askew, G.R., Roberts, V., Benoit, S., Zhou, T., Ling, V., Pfeifer, R., Stedman, N., Fitzgerald, K.A., Lin, L.L., Hall, J.P. (2010) Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol. 2010 Aug 2. [Epub ahead of print].
BMDM, Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL6, IL10, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN?, IFNb, IFN-b, IFNbeta, IFN-ß, IFNß, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, CXCL1, KC, GRO, granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: IFN-beta, IFN-gamma, GM-CSF, KC/GRO, IL-1beta, IL-6, IL-10, RANTES, TNF-alpha
Matrix tested: Mouse serum, bone marrow-derived macrophage cell culture supernatants
Summary: This study examined the role of TBK1, a member of the IKK family of protein kinases, in inflammation, using a mouse model that harbors two copies of a mutant Tbk1 allele.
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| Marr, N., Hajjar, A.M., Shah, N.R., Novikov, A., Yam, C.S., Caroff, M., Fernandez, R.C. (2010) Substitution of the Bordetella pertussis lipid A phosphate groups with glucosamine is required for robust NF-kappaB activation and release of proinflammatory cytokines in cells expressing human but not murine Toll-like receptor 4-MD-2-CD14. Infect Immun. Vol. 78(5):2060-9.
interferon, IFNgamma, IFN-g, IFN-g, IFN-?, IFN?, IFNbeta, IFN-b, IFNb, IFN-ß, IFNß, interleukin, IL1beta, IL1b, IL-1b, IL-1ß, IL1ß, IL6, tumor necrosis factor alpha, TNFa, TNF-a, TNFalpha, TNF-a, TNFa
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, TNF-alpha, IFN-beta
Matrix tested: Cell culture supernatants
Summary: This study investigated the effect of substitution of lipid A moiety of Bordetella pertussis endotoxin by glucosamine on its biological activity.
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| McIlvain, H.B., Ma, L., Ludwig, B., Manners, M.T., Martone, R.L., Dunlop, J., Kaftan, E.J., Kennedy, J.D., Whiteside, G.T. (2010) Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release. Eur J Pharmacol. Vol. 643(2-3): 202-210.
Tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Cell culture supernatants
Summary: The aim of this study was to investigate the role of purinergic receptors in mediating the morphological transformation of microglia, by using LPS as well as other receptor agonists and antagonists.
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| Moussaud, S., Draheim, H.J. (2010) A new method to isolate microglia from adult mice and culture them for an extended period of time. J Neurosci Methods. Vol. 187(2):243-253.
Interleukin, IL2, IL4, IL5, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, GRO / CXCL1
Analytes tested using MSD assays: Mouse Th1/Th2 9-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC / GRO / CINC, IL-10, IL-12, TNF-alpha)
Matrix tested: Mouse microglial cell culture supernatants
Summary: In this study, a new method for the isolation and culture of an almost pure population of microglia from adult mouse brains has been described.
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| Murphy, T., Walsh, P.M., Doran, P.P., Mulhall, K.J. (2010) Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients. J Transl Med. Vol. 8:46.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL2, IL6, IL8, IL10, IL12p70, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, Granulocyte colony stimulating factor, Granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha (MSD ProInflammatory 9-Plex Kit)
Matrix tested: Human serum
Summary: The aim of this study was to identify the genomic response induced by ischaemic preconditioning (IPC) by analyzing gene expression patterns in a cohort of total knee arthroplasty patients. IPC is an innate mechanism that increases the tolerance of tissues to prolonged ischaemia, thereby protecting them.
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| Newhall, K.J., Diemer, G.S., Leshinsky, N., Kerkof, K., Chute, H.T., Russell, C.B., Rees, W., Welcher, A.A., Patterson, S.D., Means, G.D. (2010) Evidence for endotoxin contamination in plastic Na+-heparin blood collection tube lots. Clin Chem. Vol. 56(9):1483-91. Epub 2010 Jul 27.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, Vacutainer, LPS, lipopolysaccharide
Analytes tested using MSD assays: IL-1beta, TNF-alpha (MSD custom-coated plate)
Matrix tested: Human whole blood
Summary: The aim of this study was to investigate the effects on biomarker measurement due to endotoxin-like contamination associated with specific lots of blood collection tubes. Endotoxin exposure alters the inflammatory response in the cells, thereby masking patient response in clinical trials.
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| Nguyen, H.P., Bjorkqvist, M., Bode, F.J., Stephan, M., von Horsten, S. (2010) Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease. PLoS Curr. Vol. 2: RRN1190.
Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL13, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, Keratinocyte-derived chemokine, growth-related oncogene
Analytes tested using MSD assays: IL-1beta, IL-13, KC/GRO/CINC (CXCL1), TNF-alpha
Matrix tested: Rat serum
Summary: The aim of this study was to determine whether levels of specific cytokines are elevated in the blood of a transgenic rat model containing the human Huntington's disease mutation.
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| Price, G.E., Soboleski, M.R., Lo, C., Misplon, J.A., Quirion, M.R., Houser, K.V., Pearce, M.B., Pappas, C., Tumpey, T.M., Epstein, S.L. (2010) Single-Dose Mucosal Immunization with a Candidate Universal Influenza Vaccine Provides Rapid Protection from Virulent H5N1, H3N2 and H1N1 Viruses. PLoS ONE 5(10): e13162.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL5, IL10, IL12, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, GROalpha, CXCL1, growth regulated protein
Analytes tested using MSD assays: IL-1beta, IL-2, IL-4, IL-5, IL-10, IL-12, IFN-gamma, KC / GRO / CINC, TNF-alpha
Matrix tested: Mouse bronchoalveolar alvage fluid (BALF)
Summary: This study tested a single dose universal vaccine strategy in providing protection from multiple subtypes of influenza virus. The vaccine was based on using recombinant adenoviruses that expresses two highly conserved influenza virus antigens, matrix 2 and nucleoprotein.
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| Rask, C , Brimnes, J., Lund, K. (2010) Shorter dosing intervals of sublingual immunotherapy lead to more efficacious treatment in a mouse model of allergic inflammation. Scandinavian Journal of Immunology.
Interleukin, IL2, IL4, IL5, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, GRO / CXCL1
Analytes tested using MSD assays: Mouse Th1/Th2 9-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC / GRO / CINC, IL-10, IL-12, TNF-alpha)
Matrix tested: Mouse cell culture supernatants
Summary: In this study, the immunological effect of increased SLIT dosing frequency was tested in a mouse model of allergic inflammation.
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Read, S.W., DeGrezia, M., Ciccone, E.J., DerSimonian, R., Higgins, J., Adelsberger, J.W., Starling, J.M., Rehm, C., Sereti, I. (2010) The Effect of Leflunomide on Cycling and Activation of T-Cells in HIV-1-Infected Participants. PLoS One. Vol. 5(8): e11937.
Analytes tested using MSD assays: C-reactive protein (CRP)
Matrix tested: Human plasma
Summary: This paper provides the results of a randomized, double-blinded, placebo-controlled pilot study of leflunomide, administered to HIV infected individuals, in order to assess its safety and tolerability as well as its effect on reducing immune activation.
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| Reed, J.L., De Souza, M.J., Williams, N.I. (2010) Effects of exercise combined with caloric restriction on inflammatory cytokines. Appl Physiol Nutr Metab. Vol. 35(5):573-82.
Interleukin, IL6, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, Interferon, IFN-?, IFN?, IFN-g, IFNg, IFNgamma
Analytes tested using MSD assays: IFN-gamma, IL-6, TNF-alpha
Matrix tested: Human serum
Summary: The aim of this study was to determine whether exercise combined with caloric restriction has a favorable effect on the levels of inflammatory cytokines and to identify the factors associated with exercise and diet that contribute to changes in the levels of inflammatory biomarkers.
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| Rizzetto, L., Kuka, M., De Filippo, C., Cambi, A., Netea, M.G., Beltrame, L., Napolitani, G., Torcia, M.G., D'Oro, U., Cavalieri, D. (2010) Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism. J Immunol. Vol. 184(8):4258-68.
Interleukin, IL6, IL8, IL10, IL12p70, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha
Matrix tested: Peripheral blood mononuclear cell (PBMC) supernatants
Summary: In this study, differential Th17 responses in dendritic cells exposed to pathogenic and non-pathogenic fungi have been investigated and the role of cell wall mannan in fungal immune response has been studied in detail.
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| Rosen, P.J., Sweeney, .CJ., Park, .DJ., Beaupre, D.M., Deng, H., Leitch, I.M., Shubhakar, P., Zhu, M., Oliner, K.S., Anderson, A., Yee, L.K. (2010) A phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumors. Clin Cancer Res. Vol. 16(9):2677-87.
hepatocyte growth factor, HGF, anti-angiogenic agent
Analytes tested using MSD assays: Soluble c-Met
Matrix tested: Human plasma
Summary: This paper provides the results of a clinical study that determined the safety and tolerability of the combination of AMG 102 and either bevacizumab or motesanib in the treatment of refractory advanced solid tumors. AMG 102 is an antibody against hepatocyte growth factor / scatter factor (HGF/SF).
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| Sanda, S., Bollyky, J., Standifer, N., Nepom, G., Hamerman, J.A., Greenbaum, C. (2010) Short-term IL-1beta blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes. Clin Immunol. 2010 May 17. [Epub ahead of print].
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, IL17, MCP1, Monocyte chemotactic protein 1, C-reactive protein, MIP1alpha, MIP1a, MIP-1a, MIP-1a, MIP1a, Macrophage inflammatory protein 1 alpha, Interferon, IFN-g, IFNg, IFN-?, IFN?, IFNgamma, TNFalpha, TNF-a, TNFa, TNFa, TNF-a, tumor necrosis factor
Analytes tested using MSD assays: IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, MCP-1, CRP, MIP-1alpha, IFN-gamma, TNF-alpha
Matrix tested: Human serum
Summary: This study investigated the effects of short-term administration of anakinra, an IL-1 receptor antagonist, in adults with type 1 diabetes to understand the mechanistic effects on the immune system.
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| Saric, J., Li, J.V., Swann, J., Utzinger, J., Calvert, G., Nicholson, J.K., Dirnhofer, S., Dallman, M., Bictash, M., Holmes, E. (2010) Integrated Cytokine and Metabolic Analysis of Pathological Responses to Parasite Exposure in Rodents. J Proteome Res. Vol. 9(5):2255-64.
Interleukin, IL2, IL4, IL5, IL10, IL12, IL13, GRO / CXCL1, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, tumor necrosis factor, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: Mouse TH1/TH2 9-Plex (IL-1beta, IL-2, IL-4, IL-5, IL-10, IL-12, IFN-gamma, KC / GRO, TNF-alpha), Rat Demonstration Panel (IFN-gamma, IL-1beta, IL-4, IL-5, IL-13, KC / GRO, TNF-alpha)
Matrix tested: Mouse and Rat Plasma
Summary: In this paper, cytokine profiles of four parasite-rodent models were tested in relation to their metabolic phenotypes.
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| Saric, J., Li, J.V., Utzinger, J., Wang, Y., Keiser, J., Dirnhofer, S., Beckonert, O., Sharabiani, M.T., Fonville, J.M., Nicholson, J.K., Holmes, E. (2010) Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain. Mol Syst Biol. Vol. 6:396.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL4, IL5, IL13, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, CXCL1, KC, GRO
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, IL-5, IL-13, KC/GRO, TNF-alpha (MSD Rat Demonstration 7-Plex Ultra-Sensitive Kit)
Matrix tested: Rat plasma
Summary: The focus of this study was to characterize the system-wide response of Fasciola hepatica, the causative agent of Fascioliasis, in the rat host. A multilevel statistical analysis of data generated by 1H nuclear magnetic resonance (NMR) spectroscopy was done to elucidate the main features of the infection at the systems level.
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| Song, X., Kusakari, Y., Xiao, C.Y., Kinsella, S.D., Rosenberg, M.A., Scherrer-Crosbie, M., Hara, K., Rosenzweig, A., Matsui, T. (2010) mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol. 2010 Sep 22. [Epub ahead of print].
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL6, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, cardiac hypertrophy, heart failure, inflammation, transgenic mice, mTOR
Analytes tested using MSD assays: IL-1beta, IL-6, TNF-alpha
Matrix tested: Cell culture supernatants
Summary: The aim of this study was to determine the role of mTOR expression in cardiac hypertrophy and inflammatory response by using transgenic mice with cardiac-specific overexpression of wild type mTOR.
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| Soon, E., Holmes, A.M., Treacy, C.M., Doughty, N.J., Southgate, L., Machado, R.D., Trembath, R.C., Jennings, S., Barker, L., Nicklin, P., Walker, C., Budd, D.C., Pepke-Zaba, J., Morrell, N.W. (2010) Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation. Vol. 122(9):920-7. Epub 2010 Aug 16.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, IL13, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, 384-well assay
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8,IL-10, IL-12p70, IL-13, TNF-alpha
Matrix tested: Human serum
Summary: The aim of this study was to determine the relation between inflammatory cytokines and the hemodynamics, functional capacity and overall survival of patients with pulmonary arterial hypertension.
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| Suen, K.F., Turner, M.S., Gao, F., Liu, B., Althage, A., Slavin, A., Ou, W., Zuo, E., Eckart, M., Ogawa, T., Yamada, M., Tuntland, T., Harris, J.L., Trauger, J.W. (2010) Transient expression of an IL-23R extracellular domain Fc fusion protein in CHO vs. HEK cells results in improved plasma exposure. Protein Expr Purif. Vol. 71(1):96-102.
Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IFN-gamma
Matrix tested: Human peripheral blood mononuclear cell (PBMC) supernatants
Summary: The differences in plasma exposure and in vivo activity of IL-23R Fc fusion protein were correlated with its expression in different cell lines (CHO vs HEK).
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| Sugimoto, H., Okada, K., Shoda, J., Warabi, E., Ishige, K., Ueda, T., Taguchi, K., Yanagawa, T., Nakahara, A., Hyodo, I., Ishii, T., Yamamoto, M. (2010) Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. Am J Physiol Gastrointest Liver Physiol. Vol. 298(2):G283-94.
Monocyte chemoattractant protein 1
Analytes tested using MSD assays: Adiponectin, MCP-1
Matrix tested: Mouse serum
Summary: The role of Nrf2, which serves as a cellular stress sensor, in protection against steatohepatitis has been investigated in this paper.
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| Switalla, S., Lauenstein, L., Prenzler, F., Knothe, S., Forster, C., Fieguth, H.G., Pfennig, O., Schaumann, F., Martin, C., Guzman, C.A., Ebensen, T., Muller, M., Hohlfeld, J.M., Krug, N., Braun, A., Sewald, K. (2010) Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices. Toxicol Appl Pharmacol. 2010 Apr 29. [Epub ahead of print].
Interleukin, IL1beta, IL-1b, IL1b, IL-1ß, IL1ß, IL2, IL5, IL10, IL12p70, IL13, MIP1beta, MIP1b, MIP-1b, MIP-1ß, MIP1ß, Macrophage inflammatory protein 1 beta, Interferon, IFN-g, IFNg, IFN-?, IFN?, IFNgamma, Monocyte chemotactic protein 1, Luminex, ELISA
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-5, IL-10, IL-12 p70, IL-13, MCP-1, MIP-1ß
Matrix tested: Human PCLS (precision cut lung slices) culture supernatants and PCLS lysates
Summary: The focus of this study was to compare the innate cytokine response of a human lung tissue model (precision cut lung slices) with the corresponding in vivo situation. LPS and BPPcysMPEG were tested as immunomodulators in this case.
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| Szeto, G.L., Brice, A.K., Yang, H.C., Barber, S.A., Siliciano, R.F., Clements, J.E. (2010) Minocycline attenuates HIV infection and reactivation by suppressing cellular activation in human CD4+ T cells. J Infect Dis. Vol. 201(8):1132-40.
Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, Interleukin, IL2, TNF-a, TNFa, TNFa, TNF-a, tumor necrosis factor, TNFalpha
Analytes tested using MSD assays: IFN-gamma, IL-2, TNF-alpha
Matrix tested: Human cell culture supernatants
Summary: This study investigates the mechanism of action of anti-HIV drug, minocycline, which reduces viral replication by altering the cellular environment rather than targeting the virus directly.
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| Takai, H., Kato, A., Nakamura, T., Tachibana, T., Sakurai, T., Nanami, M., Suzuki, M. (2010) The importance of characterization of FITC-labeled antibodies used in tissue cross-reactivity studies. Acta Histochem. 2010 May 21. [Epub ahead of print].
IHC, IL-6R, IL6R, FITC, Fluorescein isothiocyanate, Tissue cross-reactivity, Binding affinity, Tocilizumab
Analytes tested using MSD assays: User developed assay to measure IL-6R binding affinity to FITC labeled anti-IL-6R antibodies
Matrix tested: Peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: In this study, the effect of FITC labeling of antibody on its binding affinity and immunohistochemistry staining profile was examined using two types of humanized monoclonal antibodies against IL-6 receptors.
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| Tellabati, A., Fernandes, V.E., Teichert, F., Singh, R., Rylance, J., Gordon, S., Andrew, P.W., Grigg, J. (2010) Acute exposure of mice to high-dose ultrafine carbon black decreases susceptibility to pneumococcal pneumonia. Part Fibre Toxicol. Vol. 7:30.
Keratinocyte-derived chemokine, growth-related oncogene
Analytes tested using MSD assays: KC/GRO/CINC (CXCL1), IFN-gamma, TNF-alpha
Matrix tested: Mouse bronchoalveolar lavage fluid (BALF)
Summary: The aim of this study was to test the hypothesis that loading the alveolar macrophages with ultrafine carbon black in vivo increases the susceptibility to pneumococcal pneumonia using a mouse model.
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| Thornburg, N.J., Shepherd, B., Crowe, J.E. Jr. (2010) Transforming growth factor beta is a major regulator of human neonatal immune responses following respiratory syncytial virus infection. J Virol. Vol. 84(24):12895-902.
Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, Interleukin, IL-1b, IL1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL6, IL10, IL12p70, IL13, IL17, tumor necrosis factor, TNFalpha, TNFa, TNF-a, TNFa, TNF-a, transforming growth factor beta, TGFß, TGFbeta, TGF-b, TGFb
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-13, IL-17, TNF-alpha, TGF-beta 1
Matrix tested: Cell culture supernatants
Summary: The aim of this study was to identify the differences in dendritic cell response to RSV infections between adult and neonate populations and correlate the results to the increased susceptibility of disease observed in infants.
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| Tolcher, A.W., Sweeney, CJ., Papadopoulos, K., Patnaik, A., Chiorean, E.G., Mita, A.C., Sankhala, K., Furfine, E., Gokemeijer, J., Iacono, L., Eaton, C., Silver, B.A., Mita, M. (2010) Phase I and Pharmacokinetic Study of CT-322 (BMS-844203), a Targeted Adnectin Inhibitor of VEGFR-2 Based on a Domain of Human Fibronectin. Clin Cancer Res. Vol. 17(2):363-71.
vascular endothelial growth factor, VEGF, South Texas Accelerated Research Therapeutics, San Antonio
Analytes tested using MSD assays: VEGF-A
Matrix tested: Human plasma
Summary: This paper provides the results of a phase I clinical trial for evaluating the safety of an anti-VEGFR2 drug, CT-322, in patients with advanced malignancies. VEGF assay from MSD was used to measure its levels in plasma pre- and post-infusion of the drug.
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| von Delwig, A., Locke, J., Robinson, J.H., Ng, W.F. (2010) Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis. Arthritis Rheum. Vol. 62(1):143-9.
Interleukin, IL2, IL4, IL5, IL10, IL12, IL13, interferon, IFN?, IFN-?, IFN-g, IFNg, IFNgamma
Analytes tested using MSD assays: IFN-gamma, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13
Matrix tested: Cell culture supernatants
Summary: This study investigated whether T-cells specific for citrullinated arthritogenic aggrecan peptides are present in rheumatoid arthritis patients and compared them to healthy controls to determine if these T cells may play a role in the pathogenesis of RA in humans.
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| Vrolix, R., Mensink, R.P. (2010) Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome. Am J Clin Nutr. [Epub ahead of print].
monocyte chemoattractant protein, MCP1
Analytes tested using MSD assays: MCP-1
Matrix tested: Human plasma
Summary: The aim of this study was to investigate the effects of consumption of foods with different glycemic index and glycemic loads on the levels of metabolic risk markers in healthy overweight subjects at increased risk to develop metabolic syndrome.
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| Wine, E., Shen-Tu, G., Gareau, M.G., Goldberg, H.A., Licht, C., Ngan, B.Y., Sorensen, E.S., Greenaway, J., Sodek, J., Zohar, R., Sherman, P.M. (2010) Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions. Am J Pathol. Vol. 177(3):1320-32. Epub 2010 Jul 22.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL2, IL4, IL5, IL10, IL12, Interferon, IFNg, IFN-g, IFNgamma, IFN-?, IFN-?, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, Keratinocyte chemoattractant
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-10, IL-12, KC/GRO/CINC, TNF-alpha (MSD Mouse TH1/TH2 9-Plex Panel), IL-17
Matrix tested: Mouse colon homogenates
Summary: This study investigated the role of Osteopontin in causing gut inflammation and the pathogenesis of inflammatory bowel disease by using C. rodentium as a murine model of infectious colitis.
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| Yee, L.D., Lester, J.L., Cole, R.M., Richardson, J.R., Hsu, J.C., Li, Y., Lehman, A., Belury, M.A., Clinton, S.K. (2010) Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition. Am J Clin Nutr. Vol. 91(5):1185-94.
Interleukin, IL6, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha, docosahexaenoic acid, DHA, eicosapentaenoic acid, EPA
Analytes tested using MSD assays: IL-6, TNF-alpha
Matrix tested: Human serum
Summary: This study aimed at investigating the preclinical benefits of omega-3 polyunsaturated fatty acids in breast cancer by testing different doses of omega-3 fatty acids in women at high risk of breast cancer.
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| Young, J., Yu, X., Wolslegel, K., Nguyen, A., Kung, C., Chiang, E., Kolumam, G., Wei, N., Wong, W.L., DeForge, L., Townsend, M.J., Grogan, J.L. (2010) Lymphotoxin-aß heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis. Cytokine 2010.
TNF-a, TNFa, TNFalpha, TNF-a, TNFa, tumor necrosis factor, Interleukin, IL-1b, IL1b, IL1ß. IL-1ß, IL1beta, IL6, IL8, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFN-g, IFNg, rheumatoid arthritis, synovium
Analytes tested using MSD assays: TNF-alpha, Lymphotoxin alpha/beta, IL-1beta, IFN-gamma, IL-12p70, IL-6, IL-8, IL-10
Matrix tested: Human serum and synovial fluid
Summary: This study determines whether Lymphotoxin alpha/beta heterotrimers (members of TNF-superfamily) are cleaved from cell membranes and are active in rheumatoid arthritis.
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| Zhang, G., Wang, J., Kelly, J., Gu, G., Hou, J., Zhou, Y., Redmond, H.P., Wang, J.H., Zhang, X. (2010) B7-H3 Augments the Inflammatory Response and Is Associated with Human Sepsis. J Immunol.
Interleukin, IL1b, IL-1b, IL1beta, IL-1ß, IL1ß, IL6, IL12p70, IL12-p70, tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha
Analytes tested using MSD assays: IL-1beta, IL-6, IL-12p70, TNF-alpha
Matrix tested: Cell culture supernatants
Summary: This study demonstrated the role of soluble B7-H3, a member of B7 superfamily of costimulatory proteins, in sepsis, and showed that levels of sB7-H3 are significantly elevated in plasma of patients with sepsis as compared to healthy individuals.
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| Zhao, M., Wigren, M., Dunér, P., Kolbus, D., Olofsson, K.E., Björkback, H., Nilsson, J., Fredrikson, G.N. (2010) FcgammaRIIB inhibits the development of atherosclerosis in low-density lipoprotein receptor-deficient mice. J Immunol. Vol. 184(5):2253-60.
FcgRIIB, FcgRIIB, TH1, TH2, Interleukin, IL2, IL4, IL5, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: Mouse Th1/Th2 9-plex Ultra-Sensitive Kit (IFN-gamma, IL-1beta, TNF-alpha, IL-2, IL-12, IL-4, IL-5, IL-10, KC / GRO / CINC)
Matrix tested: Mouse plasma, mouse splenocyte cell culture supernatants
Summary: This study examines the role of the inhibitory IgG receptor Fc(gamma)RIIB in atherosclerosis.
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| Zietsch, J., Ziegenhagen, N., Heppner, F.L., Reuss, D., von Deimling, A., Holtkamp, N. (2010) The 4q12 Amplicon in Malignant Peripheral Nerve Sheath Tumors: Consequences on Gene Expression and Implications for Sunitinib Treatment. PLoS One. Vol. 5(7): e11858.
Vascular endothelial growth factor
Analytes tested using MSD assays: VEGF
Matrix tested: Cell lysates
Summary: The focus of this study was to characterize chromosomal segment, 4q12, which has a cluster of genes for several receptor tyrosine kinases, by multiplex ligation-dependent probe amplification (MLPA) method. The effect of Sunitinib on the amplification of genes in 4q12 was examined in malignant peripheral nerve sheath tumors (MPNST) cell lines.
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| Zuercher, A.W., Holvoet, S., Weiss, M., Mercenier, A. (2010) Polyphenol-enriched apple extract attenuates food allergy in mice. Clin Exp Allergy. Vol. 40(6):942-50. Epub 2010 Feb 17.
Interleukin, IL4, IL5, IL10, Interferon, IFNgamma, IFN-g, IFNg, IFN-?, IFN?, mouse Th1/Th2 9-plex
Analytes tested using MSD assays: IL-4, IL-5, IL-10, IFN-gamma
Matrix tested: Mouse cell culture supernatants
Summary: In this study, the effects of polyphenols in apple extracts on reducing the symptoms of food allergy were tested in a mouse model.
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| Bafadhel, M., Saha, S., Siva, R., McCormick, M., Monteiro, W., Rugman, P., Dodson, P., Pavord, I.D., Newbold, P., Brightling, C.E. (2009) Sputum IL-5 Concentration Is Associated with a Sputum Eosinophilia and Attenuated by Corticosteroid Therapy in COPD. Respiration. Vol. 78:256-262.
Interleukin, IL4, IL5, IL6, IL10, IL13, IL17, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, Chronic obstructive pulmonary disease
Analytes tested using MSD assays: IL-1beta, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, IFN-gamma, TNF-a, CD120a, CD120b, CD126, GM-CSF, CCL2, CCL4, CCL3, CCL5, CCL11, CCL13, CCL17, CCL22, CCL26, CXCL8, CXCL10, CXCL11, VEGF
Matrix tested: Human sputum
Summary: In this paper, sputum cytokine and chemokine profile was tested in COPD patients with or without eosinophilia for biomarker validation.
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| Bollyky, P.L., Falk, B.A., Long, S.A., Preisinger, A., Braun, K.R., Wu, R.P., Evanko, S.P., Buckner, J.H., Wight, T.N., Nepom, G.T. (2009) CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J Immunol. Vol. 183(4):2232-41.
Interleukin, IL4, IL5, IL10, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IL-1beta, IL-4, IL-5, IL-10, IFN-gamma, TNF-a
Matrix tested: Human PBMC and mouse leukocyte cell culture supernatants
Summary: In this paper, the mechanism of the interaction between extracellular matrix receptor (CD44) and its ligand Hyaluronan (HA) has been studied with regard to regulatory T cell function.
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| Brignone, C., Escudier, B., Grygar, C., Marcu, M., Triebel, F. (2009) A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma. Clin Cancer Res. Vol. 15(19):6225-31.
Interleukin, IL6, IL8, IP10, MCP1, MCP4, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, MIP-1b, MIP1b, MIP-1ß, MIP1ß, MIP1beta, monocyte chemotactic protein, Macrophage-Derived Chemokine, Thymus and Activation Regulated Chemokine, Interferon Inducible Protein 10, tumor necrosis factor
Analytes tested using MSD assays: Human ProInflammatory 4-plex (IFN-gamma, IL-1beta, IL-6, TNF-alpha), and Human Chemokine 9-plex (Eotaxin, Eotaxin-3, IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1beta, and TARC)
Matrix tested: Human plasma
Summary: In this paper, the pharmacokinetics of an anti-cancer drug, IMP321, in a Phase I clinical trial has been studied.
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| Cardin, R.D., Bravo, F.J., Sewell, A.P., Cummins, J., Flamand, L., Juteau, J.M., Bernstein, D.I., Vaillant, A. (2009) Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection. Virol J. Vol. 6:214.
Interleukin, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, IL13, IP10, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, Interferon Inducible Protein 10, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha, IP-10
Matrix tested: Human peripheral blood mononuclear cell (PBMC) supernatants
Summary: Here, the in vivo effect of phosphorothioated oligonucleotides against Cytomegaloviral infections was studied.
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| Chiang, P.C., Hu, Y., Thurston, A., Sommers, C.D., Guzova, J.A., Kahn, L.E., Lai, Y., Blom, J.D. (2009) Pharmacokinetic and pharmacodynamic evaluation of the suitability of using fluticasone and an acute rat lung inflammation model to differentiate lung versus systemic efficacy. J Pharm Sci. Vol. 98(11):4354 -4364.
TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, lung inflammation, glucocorticoids, PK/PD
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Rat bronchoalveolar lavage fluid (BALF)
Summary: In this study, the efficacy of inhaled fluticasone has been examined with respect to that arising from local pulmonary exposures as compared to systemic exposure. Different formulations of fluticasone were used to demonstrate lung targeted efficacy in the lipopolysaccharide induced inflammation rat model.
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| Chowdhury, F., Williams, A. (2009) From research to regulated: challenges in transferring methods. Bioanalysis. Vol. 1(2):285-291.
Luminex, MESO SCALE DISCOVERY, clinical
Summary: This report summarizes some of the challenges as well as the solutions that academic units have in order to successfully transfer techniques from a research laboratory to a clinical setting for phase I trials.
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| Chowdhury. F., Williams, A., Johnson, P. (2009) Validation and comparison of two multiplex technologies, Luminex® and Mesoscale Discovery, for human cytokine profiling. J Immunol Methods. Vol. 340(1):55-64.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor
Analytes tested using MSD assays: Human TH1/TH2 10-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha)
Matrix tested: Human plasma
Summary: Two multiplex platforms have been directly compared here for measurement of human cytokines in ex-vivo stimulated whole blood.
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| Christensen, E., Pintilie, M., Evans, K.R., Lenarduzzi, M., Menard, C., Catton, C.N., Diamandis, E.P., Bristow, R.G. (2009) Longitudinal cytokine expression during IMRT for prostate cancer and acute treatment toxicity. Clin Cancer Res. Vol. 15(17):5576-83.
Interleukin, IL2, IL6, IL8, IL10, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, granulocyte macrophage colony stimulating factor, tumor necrosis factor
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha
Matrix tested: Human serum
Summary: This paper studies the expression of specific cytokines correlating with differential toxicity in prostrate cancer patients undergoing radiation therapy.
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| Christian, L.M., Franco, A., Glaser, R. Iams, J.D. (2009) Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women. Brain, Behavior, and Immunity. Vol. 23 (6):750-754.
Interleukin, IL6, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a
Analytes tested using MSD assays: IL-6, TNF-alpha
Matrix tested: Human serum
Summary: This study examines the associations between stress, depressive symptoms, and serum inflammatory markers in a sample of 60 pregnant women to test whether inflammation is a likely mechanism by which distress can cause negative perinatal outcomes.
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| Chung, D.J., Rossi, M., Romano, E., Ghith, J., Yuan, J., Munn, D.H., Young, J.W. (2009) Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells. Blood. Vol. 114(3):555-563.
Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IFN-gamma
Matrix tested: Human leukocyte cell culture supernatants
Summary: In this paper, an Indoleamine 2,3-dioxygenase (IDO) dependent mechanism of regulatory T cell (Tregs) expansion by dendritic cells has been identified and discussed in detail.
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| Clarke, S., Laxton, C., Horscroft, N., Richard, V., Thomas, A., Parkinson, T. (2009) Comparison of Rat and Human Responses to Toll-Like Receptor 7 Activation. J Interferon Cytokine Res. Vol. 29(2):113-26.
Interleukin, IL6, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, Interferon, Interferon alpha 2a, IFNa2a, IFN-a2a, IFN-a2a, IFNa2a, interferon-alpha-2a
Analytes tested using MSD assays: IL-1beta, IL6, TNF-alpha, IFN-alpha2a
Matrix tested: Human and rat peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: In this paper, the responses to Toll like receptor 7 (TLR7) agonist, SM360320, was investigated in rats and human PBMCs, and compared to the responses observed in whole animals.
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| Cockcroft, N.Y., Oke, O., Cunningham, F., Bishop, E., Fearon, I.M., Zantl, R., Gaca, M.D. (2009) An in vitro perfusion system to examine the responses of endothelial cells to simulated flow and inflammatory stimulation. Altern Lab Anim. Vol. 37(6):657-69.
IL6, IL8, Interleukin, monocyte chemotactic protein-1, MCP1
Analytes tested using MSD assays: IL-6, IL-8, MCP-1
Matrix tested: Human umbilical vein endothelial cell (HUVEC) culture medium
Summary: In this study, a simulated blood flow perfusion system was developed in vitro to test the effect of different flow patterns on the formation of atherosclerotic lesions.
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| Di Sabatino, A., Rovedatti, L., Kaur, R., Spencer, J.P., Brown, J.T., Morisset, V.D., Biancheri, P., Leakey, N.A., Wilde, J.I., Scott, L., Corazza, G.R., Lee, K., Sengupta, N., Knowles, C.H., Gunthorpe, M.J., McLean, P.G., MacDonald, T.T., Kruidenier, L. (2009) Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. J Immunol. Vol. 183(5):3454-62.
Interleukin, IL2, IL8, IL17, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IFN-gamma, IL-2, IL-8, IL-17
Matrix tested: Cell culture supernatants from human endoscopic biopsy and surgical specimens
Summary: This paper proposes the Ca(2+) release-activated Ca(2+) (CRAC) channel as a potential therapeutic target for the treatment of inflammatory bowel disease (IBD) and characterizes the use of a CRAC channel inhibitor, Synta 66, to inhibit T cell cytokine production, T-bet expression and proliferation of T cells in gut-derived lamina propria mononuclear cells (LPMCs) and organ cultures of IBD biopsy specimens.
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| Enewold, L., Mechanic, L.E., Bowman, E.D., Zheng, Y.L., Yu, Z., Trivers, G., Alberg, A.J., Harris, C.C. (2009) Serum concentrations of cytokines and lung cancer survival in African Americans and Caucasians. Cancer Epidemiol Biomarkers Prev. Vol. 18(1):215-22.
Interleukin, IL4, IL5, IL6, IL8, IL10, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha
Matrix tested: Human serum
Summary: This paper shows the results of a case-control study in which the association between different proinflammatory and anti-inflammatory cytokines with lung cancer survival has been tested.
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| Engstrom, L., Pinzon-Ortiz, M.C., Li, Y., Chen, S.C., Kinsley, D., Nelissen, R., Fine, J.S., Mihara, K., Manfra, D. (2009) Characterization of a murine keyhole limpet hemocyanin (KLH)-delayed-type hypersensitivity (DTH) model: role for p38 kinase. Int Immunopharmacol. Vol. 9(10):1218-27.
tumor necrosis factor, TNFa, TNF-a, TNF-a, TNFa, TNFalpha
Analytes tested using MSD assays: TNF-alpha, phosphorylated and total p38, phosphorylated and total JNK, phosphorylated and total ERK
Matrix tested: Mouse ear whole organ cultures, ear lysates, lymph node lysates
Summary: The focus of this study was to characterize the delayed type hypersensitivity response induced by KLH at a cellular and molecular level, and use this model to evaluate the effects of an immunomodulator, BIRB-796.
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| Frick, J.S., MacManus, C.F., Scully, M., Glover, L.E., Eltzschig, H.K., Colgan, S.P. (2009) Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol. Vol. 182(8):4957-64.
Interleukin, IL2, IL4, IL5, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC/GRO/CINC, IL-10, IL-12, TNF-a
Matrix tested: Mouse colon lysates
Summary: In this study, the role of Adenosine receptor (A2B) expressed on murine intestinal epithelial cells on experimentally induced colitis was tested.
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| Friese, R.S., Rao, F., Khandrika, S., Thomas, B., Ziegler, M.G., Schmid-Schönbein, G.W., O'Connor, D.T. (2009) Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease. Clin Exp Hypertens. Vol. 31(7):521-33.
matrix metalloproteinase
Analytes tested using MSD assays: MMP-1, MMP-2, MMP-3, MMP-10
Matrix tested: Human plasma
Summary: In this paper, the role of MMPs as inflammatory mediators in complicated as well as uncomplicated hypertension was studied.
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| Getz, E.B., Fisher, D.M., Fuller, R. (2009) Human pharmacokinetics/pharmacodynamics of an interleukin-4 and interleukin-13 dual antagonist in asthma. J Clin Pharmacol. Vol. 49(9):1025-36.
pitrakinra, IL4, Interleukin
Analytes tested using MSD assays: Customer developed assay for a drug
Matrix tested: Human plasma
Summary: The pharmacokinetics of a human IL-4 mutein that binds to IL-4 receptor was studied in this paper and compared to the pharmacological response in asthma.
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| Gourh, P., Arnett, F.C., Assassi, S., Tan, F.K., Huang, M., Diekman, L., Mayes, M.D., Reveille, J.D., Agarwal, S.K. (2009) Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations. Arthritis Res Ther. Vol. 11(5):R147.
Interleukin, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, IL13, IL17, IL23, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, TNF-alpha, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17, IL-23
Matrix tested: Human plasma
Summary: This study determines whether plasma cytokine profiles differ in systemic sclerosis patients grouped according to the three different SSc associated autoantibody subsets, anticentromere antibodies (ACAs), anti-topoisomerase antibodies (ATAs), and anti-RNA polymerase III antibodies (ARAs). The role of MMPs as inflammatory mediators in complicated as well as uncomplicated hypertension was studied.
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| Grip, O., Janciauskiene, S. (2009) Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease. PLoS ONE. Vol. 4(5):5263.
IL8, IP10, Interleukin, IL8, IP10, MCP1, MCP4, MIP-1b, MIP1b, MIP-1ß, MIP1ß, MIP1beta, monocyte chemotactic protein, Macrophage-Derived Chemokine, Thymus and Activation Regulated Chemokine, Interferon Inducible Protein 10
Analytes tested using MSD assays: MCP-1, MIP-1beta, Eotaxin, MCP-4, TARC, MDC, Eotaxin-3, IL-8, IP-10, P-selectin,, E-selectin, sICAM-3, Thrombomodulin
Matrix tested: Human plasma
Summary: Plasma levels of cytokines and chemokines in Crohn's disease patients administered with statins were measured to determine whether chemokine expression reduces after statin treatment.
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| Hu, Y.L., Metz, D.P., Chung, J., Siu, G., Zhang, M. (2009) B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. J Immunol. Vol. 182(3):1421-8.
Interferon, IFN-g, IFNg, IFNgamma, IFN-g, IFNg
Analytes tested using MSD assays: IFN-gamma
Matrix tested: Mouse lymphocyte cell culture medium
Summary: This paper discusses the critical role played by ICOS and its ligand, B7RP-1, in enhancing the development of autoimmune diseases in murine models of rheumatoid arthritis and systemic lupus erythematosus.
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| Keely, S., Ryan, S.M., Haddleton, D.M., Limer, A., Mantovani, G., Murphy, E.P., Colgan, S.P., Brayden, D.J. (2009) Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers. J Control Release. Vol. 135(1):35-43.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: Human TH1/TH2 10-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha)
Matrix tested: Human cell culture supernatants (Caco-2)
Summary: In this paper, a mucoadhesive polymer, pDMAEMA, was synthesized and conjugated to dexamethasone (DEX) and the adhesive as well as anti-inflammatory properties of this conjugate (DEX-pDMAEMA) was studied in human intestinal monolayers.
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| Keun, H.C., Sidhu, J., Pchejetski, D., Lewis, J.S., Marconell, H., Patterson, M., Bloom, S.R., Amber, V., Coombes, R.C., Stebbing, J. (2009) Serum molecular signatures of weight change during early breast cancer chemotherapy. Clin Cancer Res. Vol. 15(21):6716-23.
IL6, Interleukin, TNFa, TNF-a, TNFalpha, TNFa, tumor necrosis factor, TNF-a
Analytes tested using MSD assays: IL-6, TNF-alpha
Matrix tested: Human serum
Summary: In this paper, metabolic and cytokine profiles of breast cancer patients undergoing chemotherapy was studied to gain insights into the physiologic processes associated with weight gain in these patients.
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| Kleinschek, M.A., Boniface, K., Sadekova, S., Grein, J., Murphy, E.E., Turner, S.P., Raskin, L., Desai, B., Faubion, W.A., de Waal Malefyt, R., Pierce, R.H., McClanahan, T., Kastelein, R.A. (2009) Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J Exp Med. Vol. 206(3):525-34.
Interferon, Interleukin, IL17, IL17F, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IFN-gamma, IL-17, IL-17F
Matrix tested: Human cell culture supernatants
Summary: This study identified that there exists an abundance of TH17 cells expressing CD161+ receptor in the intestines of Crohn's disease patients and this Th17 cell pool can be activated by IL-23 to cause destructive tissue inflammation.
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| Koppe, S.W., Elias, M., Moseley, R.H., Green, R.M. (2009) Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Am J Physiol Gastrointest Liver Physiol. Vol. 297(2):G378-84.
IL-1b, IL-1ß, IL1ß, IL1beta, Interleukin
Analytes tested using MSD assays: Insulin, Leptin, IL-1beta
Matrix tested: Mouse serum and liver / hepatic tissue lysates
Summary: In this paper, the effect of high trans fat diet on the development of nonalcoholic fatty liver disease was examined and compared to a high fat diet devoid of trans fats.
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| Kuai, J., Gregory, B., Hill, A., Pittman, D.D., Feldman, J.L., Brown, T., Carito, B., O'Toole, M., Ramsey, R., Adolfsson, O., Shields, K.M., Dower, K., Hall, J.P., Kurdi, Y., Beech, J.T., Nanchahal, J., Feldmann, M., Foxwell, B.M., Brennan, F.M., Winkler, D.G., Lin, L.L. (2009) TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford). Vol. 48(11):1352-8.
Triggering receptor expressed on myeloid cells-1, TREM1, rheumatoid arthritis, Interleukin, IL-1b, IL-1ß, IL1ß, IL1beta, IL8, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, Granulocyte Macrophage Colony Stimulating Factor
Analytes tested using MSD assays: IL-1beta, IL-8, GM-CSF, TNF-alpha
Matrix tested: Human synovium cell culture supernatants from Rheumatoid arthritis patients
Summary: In this paper, the expression and the role of TREM-1 in the synovium of rheumatoid arthritis patients was investigated and the level of TREM-1 in plasma of these patients was assessed.
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| Kuhle, J., Lindberg, R.L., Regeniter, A., Mehling, M., Steck, A.J., Kappos, L, Czaplinski, A. (2009) Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis. Eur J of Neurology. Vol. 16(6):771-4.
chemokine, IL8, Interleukin, IP10, Macrophage Derived Chemokine, Macrophage Inflammatory Protein, Thymus and Activation Regulated Chemokine, Interferon Inducible Protein, Monocyte Chemotactic Protein
Analytes tested using MSD assays: Eotaxin, Eotaxin-3, IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1beta, TARC
Matrix tested: Human serum and cerebrospinal fluid (CSF)
Summary: In this paper, the levels of inflammatory markers in amyotrophic lateral sclerosis were studied in comparison to other non-inflammatory neurological diseases.
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| Lembo, A., J, Neri, B., Tolley, J., Barken, D., Carroll, S., Pan, H. (2009) Use of serum biomarkers in a diagnostic test for irritable bowel syndrome. Aliment Pharmacol Ther. Vol. 29(8):834-42.
Interleukin, IL1ß, IL-1ß, IL1b, IL1beta, IL-1b, Brain derived neurotrophic factor, TNF-alpha like weak inducer of apoptosis, Tissue Inhibitor of Metalloproteinase-1, Neutrophil gelatinase associated lipocalin, Growth-related oncogene- a, IBS
Analytes tested using MSD assays: IL-1beta, BDNF, TWEAK, TIMP-1, NGAL, GRO-a
Matrix tested: Human serum
Summary: In this study, a set of 10 biomarkers were selected out of a panel of 140 markers to develop a diagnostic test for Irritable Bowel Syndrome.
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| Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Björkqvist, M., Träskman-Bendz, L., Brundin, L. (2009) Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity. Biol Psychiatry. Vol. 66(3):287-92.
CSF, Interleukin, IL1ß, IL-1ß, IL1b, IL1beta, IL6, IL8, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, major depressive disorder, depression
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, TNF-alpha
Matrix tested: Human cerebrospinal fluid, human plasma
Summary: In this study, cytokines in cerebrospinal fluid of suicide attempters were measured to identify immune system alterations associated with depressive disorders.
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| Liu, Y., Zhu, L., Fatheree, N.Y., Liu, X., Pacheco, S.E., Tatevian, N., Rhoads, J.M. (2009) Changes in Intestinal Toll-like Receptors and Cytokines Precede Histological Injury in a Rat Model of Necrotizing Enterocolitis. Am J Physiol Gastrointest Liver Physiol. Vol. 297(3):442-50.
Interleukin, IL1ß, IL-1ß, IL1b, IL1beta, IL-1b, keratinocyte derived chemokine / growth related oncogene, IL4, IL5, IL13, TNFa, TNF-a, TNFalpha, tumor necrosis factor, TNFa, TNF-a
Analytes tested using MSD assays: IFN-gamma, IL-1beta, TNF-alpha, KC / GRO/ CXCL1, IL-4, IL-5, IL-13
Matrix tested: Rat ileal tissue lysates
Summary: The role of Toll-like receptor signaling and cytokine expression in the pathogenesis of neonatal necrotizing enterocolitis has been studied in detail in this paper.
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| Maanen, M.A., Stoof, S.P., van der Zanden, E.P., de Jonge, W.J., Janssen, R.A., Fischer, D.F., Vandeghinste, N., Brys, R., Vervoordeldonk, M.J., Tak, P.P. (2009) The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation. Arthritis Rheum. Vol. 60(5):1272-81.
Interleukin, IL8
Analytes tested using MSD assays: IL-8
Matrix tested: Tissue culture supernatants from Rheumatoid Arthritis FLS (Fibrobalst like synoviocytes collected and cultured from human synovial fluid)
Summary: The paper discusses the importance of a neurotransmitter (acetylcholine) in synovial inflammation and thus rheumatoid arthritis. Screening for cell surface expressed or secreted proteins was conducted that when down regulated can up-regulate proinflammatory cytokine expression.
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| Mak, G.J., Ledwidge, M.T., Watson, C.J., Phelan, D.M., Dawkins, I.R., Murphy, N.F., Patle, A.K., Baugh, J.A., McDonald, K.M. (2009) Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone. J Am Coll Cardiol. Vol. 54(18):1674-82.
Interleukin, IL6, IL8, monocyte chemoattractant protein 1, C-reactive protein, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a
Analytes tested using MSD assays: IL-6, IL-8, TNF-alpha, MCP-1, CRP
Matrix tested: Human serum
Summary: This study assessed collagen turnover in preserved systolic function heart failure (HFPSF) patients and tested whether treatment with the aldosterone antagonist eplerenone has an impact on abnormalities in collagen metabolism in these patients.
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| Astengo, M., Dahl, A., Karlsson, T., Mattsson-Hultén, L., Wiklund, O., Wennerblom, B. (2009) Physical training after percutaneous coronary intervention in patients with stable angina: effects on working capacity, metabolism, and markers of inflammation. European Journal of Cardiovascular Prevention & Rehabilitation. [Epub in circulation].
Interleukin, IL8, IL6, IL10, c reactive protein
Analytes tested using MSD assays: C-reactive protein (CRP), serum amyloid A (SAA), IL-6, IL-8, IL-10
Matrix tested: Human serum
Summary: This study tested the hypothesis that exercise training improves glucose and lipid metabolism, the inflammatory / anti-inflammatory balance, and the outcome of elective percutaneous coronary intervention in patients with stable coronary disease.
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| Matt, P., Schoenhoff, F., Habashi, J., Holm, T., Van Erp, C., Loch, D., Carlson, O.D., Griswold, B.F., Fu, Q., Backer, J.D., PhD, Loey, B., Huso, D.L., McDonnell, N.B., Van Eyk, J.E., Dietz, H.C. (2009) Circulating Transforming Growth Factor-ß in Marfan Syndrome. Journal of American Heart Association. Vol. 120(6):526-32.
Transforming growth factor, TGFß1, TGF-ß1, TGFbeta
Analytes tested using MSD assays: TGF-beta1
Matrix tested: Human plasma
Summary: In this clinical study, the effects of a drug, losartan (blocks TGFß1 activation) on Marfan Syndrome were tested.
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| Mentor-Marcel, R.A., Bobe, G., Barrett, K.G., Young, M.R., Albert, P.S., Bennink, M.R., Lanza, E., Colburn, N.H. (2009) Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice. Cancer Prev Res. Vol. 2(1):60-9.
Interleukin, IL2, IL4, IL5, IL6, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, Granulocyte Macrophage Colony Stimulating Factor, Monocyte Chemotactic Protein
Analytes tested using MSD assays: Mouse Th1/Th2 9-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC / GRO / CINC, IL-10, IL-12, TNF-alpha), Mouse Custom Metabolic Panel (IL-6, GM-CSF, Insulin, MCP-1, Resistin)
Matrix tested: Mouse serum
Summary: This paper is based on the study of changes in specific obesity or inflammation related proteins and the corresponding genes in colon mucosa as a result of modification of diet.
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| Patel, A., Murray, J., McElwee-Whitmer, S., Bai, C., Kunapuli, P., Johnson, E.N. (2009) A combination of ultrahigh throughput PathHunter and cytokine secretion assays to identify glucocorticoid receptor agonists. Anal Biochem. Vol. 385(2):286-92.
Interleukin, IL6, IL8, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, TNF-alpha
Matrix tested: Cell culture supernatants
Summary: In this study, Path Hunter technology (a registered trademark of DiscoveRx Corporation) combined with cytokine secretion assays were used to screen an entire Merck compound library for glucocorticoid receptor (GR) agonists in a 3456-well plate format.
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| Patel, K.D., Duggan, S.P., Currid, C.A., Gallagher, W.M., McManus, R., Kelleher, D., Murphy, R.T., Ryan, A.W. (2009) High sensitivity cytokine detection in acute coronary syndrome reveals up-regulation of Interferon Gamma and Interleukin-10 post Myocardial Infarction. Clinical Immunology. Vol. 133(2):251-6.
Interleukin, IL2, IL6, IL8, IL10, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor, Granulocyte Macrophage Colony Stimulating Factor, Monocyte Chemotactic Protein
Analytes tested using MSD assays: Human ProInflammatory 9-Plex Ultra-Sensitive Kit (GM-CSF, IFN-gamma, IL-1beta, IL-10, IL-12 p70, IL-2, IL-6, IL-8, TNF-alpha)
Matrix tested: Human serum
Summary: This is a clinical study to determine specific cytokines that are upregulated in myocardial infarction and can therefore serve as biomarkers for the same.
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| Prencipe, M., Fitzpatrick, P., Gorman, S., Tosetto, M., Klinger, R., Furlong, F., Harrison, M., O'Connor, D., Roninson, I.B., O'Sullivan, J., McCann, A. (2009) Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro. Br J Cancer. Vol. 101(11):1900-8.
Interleukin, IL6, IL8, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, mitotic arrest deficiency protein, chemotherapy
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8
Matrix tested: MCF7 cell culture supernatants
Summary: In this paper, the role of MAD2 protein levels have been studied in association with developing resistance to a chemotherapeutic drug called paclitaxel.
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| Redd, A.D., Dabitao, D., Bream, J.H., Charvat, B., Laeyendecker, O., Kiwanuka, N., Lutalo, T., Kigozi, G., Tobian, A.A., Gamiel, J., Neal, J.D., Oliver, A.E., Margolick, J.B., Sewankambo, N., Reynolds, S.J., Wawer, M.J., Serwadda, D., Gray, R.H., Quinn, T.C. (2009) Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa. Proc Natl Acad Sci U S A. Vol. 106(16):6718-23.
Interleukin, IL2, IL6, IL8, IL10, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor, granulocyte macrophage colony stimulating factor
Analytes tested using MSD assays: GM-CSF, IFN-gamma, IL-1beta, IL-2, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha
Matrix tested: Human serum
Summary: This study explored the longitudinal relationship between microbial translocation, immune activation and circulating inflammatory cytokine response in a cohort of HIV-1 infected individuals with different rates of disease progression.
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| Remondo, C., Cereda, V., Mostbock, S., Sabzevari, H., Franzusoff, A., Schlom, J., Tsang, K.Y. (2009) Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen. Vaccine. Vol. 27(7):987-94.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha
Matrix tested: Human dendritic cell culture supernatants
Summary: This study examines the use of a yeast vector containing the transgene for human carcinoembryonic antigen (CEA) in cancer immunotherapy due to its ability to activate human dendritic cells (DCs) and stimulate CEA-specific T-cell responses.
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| Russell, F.A., Fernandesa, E.S., Couradeb J.P., Keeblea, J.E., Brain, S.D. (2009) Tumour necrosis factor a mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1ß, protein kinase C and cyclooxygenase-2 signaling. Pain. Vol. 142(3):264-274.
Interleukin, IL6, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor
Analytes tested using MSD assays: IL-1beta, IL-6, IL-10, IL-12, IFN-gamma, KC / GRO / CINC, TNF-alpha
Matrix tested: Mouse paw homogenates
Summary: In this study, the mechanisms that link the inflammatory and nociceptive effects of TNF-alpha have been examined.
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Russo, A.L., Jedlicka, K., Wernick, M., McNally, D., Kirk, M., Sproull, M., Smith, S., Shankavaram, U., Kaushal, A., Figg, W.D., Dahut, W., Citrin, D., Bottaro, D.P., Albert, P.S., Tofilon, P.J., Camphausen, K. (2009) Urine Analysis and Protein Networking Identify Met as a Marker of Metastatic Prostate Cancer. Clin Cancer Res. Vol. 15(13):4292-4298.
Analytes tested using MSD assays: Met
Matrix tested: Urine
Summary: This study is based on the validation of Met as a marker for metastatic prostrate cancer since its levels differ significantly between localized disease group and the metastatic group.
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| Sears, D.D., Miles, P.D., Chapman, J., Ofrecio, J.M., Almazan, F., Thapar, D., Miller, Y.I. (2009) 12/15-Lipoxygenase Is Required for the Early Onset of High Fat Diet-Induced Adipose Tissue Inflammation and Insulin Resistance in Mice. PLoS One. Vol. 4 (9):7250.
Interleukin, IL6, IL10, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC / GRO / CINC, TNF-alpha
Matrix tested: Mouse epididymal white adipose tissue (eWAT) lysates and plasma
Summary: In this paper, the authors tested whether 12/15-Lipoxygenase gene product is associated with high fat diet induced insulin resistance in mice.
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| Siddiqui, S., Cruse, G., McKenna, S., Monteiro, W., Mistry, V., Wardlaw, A., Brightling, C. (2009) IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis. BMC Pulmonary Medicine. Vol. 9:34.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, IL8, Monocyte Chemotactic Protein, Macrophage-Derived Chemokine, Thymus and Activation Regulated Chemokine, Interferon Inducible Protein 10, MIP1ß, MIP1b, MIP1beta
Analytes tested using MSD assays: Human TH1/TH2 10-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha), Human Chemokine 9-Plex (Eotaxin, Eotaxin-3, IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1beta, TARC)
Matrix tested: Human serum
Summary: This study is based on the comparison of IL-13 expression in peripheral blood T-cells and eosinophils from asthma patients with healthy controls and attempts to identify an inflammatory stimulus for this expression.
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| Singh, B.N., Hayes, G.R., Lucas, J.J., Sommer, U., Viseux, N., Mirgorodskaya, E., Trifonova, R.T., Sassi, R.R., Costello, C.E., Fichorova, R.N. (2009) Structural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function. Glycoconj J. Vol. 26(1):3-17.
Interleukin, IL8, ERK, NF kappa B, MAPK, Vaginal mucosal immunity
Analytes tested using MSD assays: IL-8, Phospho ERK1/2, Phospho NF-kappaB/p65 (Ser538), Phospho MEK
Matrix tested: Human epithelial cell culture supernatants
Summary: This study examines the biochemical nature of Trichomonas vaginalis surface lipophosphoglycan (LPG) and determines the molecular domains necessary for host immunoinflammatory response.
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| Sjöberg, S., Eriksson, E.E., Tivesten, A., Carlsson, A., Klasson, A., Levin, M., Borén, J., Krettek, A. (2009) CD44-deficiency on hematopoietic cells limits T-cell number but does not protect against atherogenesis in LDL receptor-deficient mice. Atherosclerosis. Vol. 206(2):369-74.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: Mouse Th1/Th2 9-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, KC / GRO / CINC, IL-10, IL-12, TNF-alpha)
Matrix tested: Mouse cell culture supernatants
Summary: In this study, bone marrow reconstitution experiments were done in low density lipoprotein (LDL) receptor deficient mouse model to test whether CD44 expressed by hematopoietic cells plays a critical role in the pathology of atherogenesis.
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| Symonds, E.L., Riedel, C.U., O'Mahony, D., Lapthorne, S., O'Mahony, L., Shanahan, F. (2009) Involvement of T helper type 17 and regulatory T cell activity in Citrobacter rodentium invasion and inflammatory damage. Clinical & Experimental Immunology. Vol. 157(1):148-154.
Interleukin, IL6, IL10, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, IL8, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC / GRO / CXCL1, TNF-alpha
Matrix tested: Mouse cell culture supernatants
Summary: In this paper, the main signaling events associated with the clearance of Citrobacter rodentium (induces colitis) from the colon have been studied in mice.
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| Trifonova, R.T., Doncel, G.F., Fichorova, R.N. (2009) Polyanionic Microbicides Modify TLR_mediated Cervicovaginal immune response. Antimicrob Agents Chemother. Vol. 53(4):1490-500.
Interleukin, Interferon, IL8, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, IFNb, IFB-b, IFNbeta, IFN-ß, IFNß, HIV-1
Analytes tested using MSD assays: IL-8, IL-1beta, IFN-beta
Matrix tested: Human cervical and vaginal epithelial cell culture supernatants and lysates
Summary: This study tests the effects of anti-HIV microbicides dextran sulfate and polystyrene sulfonate on Toll-like receptor signaling in human epithelial cell lines.
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| Urry, Z., Xystrakis, E., Richards, D.F., McDonald, J., Sattar, Z., Cousins, D.J., Corrigan, C.J., Hickman, E., Brown, Z., Hawrylowicz, C.M. (2009) Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest. Vol. 119(2):387-98.
Interleukin, IL5, IL10, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IL-5, IL-10, IL-13, IFN-gamma
Matrix tested: Human peripheral blood mononuclear cell (PBMC) supernatants
Summary: In this paper, the effect of 1a25VitD3 (the active form of Vitamin D) on IL-10 producing Treg cells and Toll like receptor signaling has been discussed.
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| Watson, J.A., Watson, C.J., McCrohan, A.M., Woodfine, K., Tosetto, M., McDaid, J., Gallagher, E., Betts, D., Baugh, J., O'Sullivan, J., Murrell, A., Watson, R.W., McCann, A. (2009) Generation of an epigenetic signature by chronic hypoxia in prostate cells. Human Molecular Genetics. Vol. 18(19):3594-604.
Interleukin, IL8, IL6, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8 and TNF-alpha
Matrix tested: Tissue culture supernatants
Summary: In this study, a benign prostrate cancer cell line has been compared to a hypoxic-conditioned prostrate cancer cell line to identify phenotypic and epigenetic consequences of chronic hypoxia in relation to cancer, apoptosis, invasion and cellular senescence.
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| Wigren, M., Bengtsson, D., Dunér, P., Olofsson, K., Björkbacka, H., Bengtsson, E., Fredrikson, G.N., Nilsson, J. (2009) Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells. Circ Res. Vol. 104(12):62-70.
Interleukin, IL2, IL4, IL5, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: Mouse TH1/TH2 9-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-10, IL-12, KC / GRO / CINC, TNF-alpha)
Matrix tested: Mouse splenocyte cell culture supernatants
Summary: In this paper, the mechanism for anti-atherogenic properties of alum has been investigated by administering alum in the absence of an antigen into mice.
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| Willett, C.G., Duda, D.G., di Tomaso, E., Boucher, Y., Ancukiewicz, M., Sahani, D.V., Lahdenranta, J., Chung, D.C., Fischman, A.J., Lauwers, G.Y., Shellito, P., Czito, B.G., Wong, T.Z., Paulson, E., Poleski, M., Vujaskovic, Z., Bentley, R., Chen, H.X., Clark, J.W., Jain, R.K. (2009) Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study. Journal of Clinical Oncology. Vol. 27(18):3020-3026.
Vascular endothelial growth factor receptor, Placental growth factor, Basic fibroblast growth factor, Granulocyte macrophage colony-stimulating factor, Interleukin, IL6, IL8, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor
Analytes tested using MSD assays: soluble VEGFR, VEGF, PlGF, bFGF, GM-CSF, IL-1beta, IL-6, IL-8, and TNF-alpha
Matrix tested: Human EDTA plasma
Summary: This is a phase II clinical study determining the effects of Bevacizumab treatment on localized rectal cancer.
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| Xu, Y., Li, J., Ferguson, G.D., Mercurio, F., Khambatta, G., Morrison, L. Lopez-Girona, A., Corral, L.G., Webb, D.R., Bennett, B.L., Xie, W. (2009) Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases. Blood. Vol. 114(2):338-345.
Interleukin, IL2
Analytes tested using MSD assays: Human IL-2
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: In this paper, the mechanism of action of immunomodulatory drugs has been investigated.
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| Yang, J.B., James, E., Roti, M., Huston, L., Gebe, J.A., Kwok, W.W. (2009) Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals. Intrnl Immuno. Vol. 21(1):63-71.
Interleukin, IL5, IL10, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IFN-gamma, IL-5, IL-10, IL-13
Matrix tested: Human serum
Summary: In this study, the authors have developed a novel tetramer guided epitope mapping (TGEM) method to identify dominant CD4+ T-cell epitopes in SARS virus from subjects that have not been exposed to the pathogen.
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| Yamasaki, S, Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S., Saito, T. (2009) C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc Natl Acad Sci USA. Vol. 106(6):1897-902.
ITAM, TNF, IL-10, KC / GRO / CINC
Analytes tested using MSD assays: Cytokines (specific cytokines not mentioned)
Matrix tested: Malassezia activated macrophage culture
Summary: In this study, the role of Mincle receptor in eliciting an immune response to Malassezia fungal infections has been examined.
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| Zhu, A.X., Sahani, D.V., Duda, D.G., di Tomaso, E., Ancukiewicz, M., Catalano, O.A., Sindhwani, V., Blaszkowsky, L.S. Yoon, S.S., Lahdenranta, J., Bhargava, P., Meyerhardt, J. Clark, J.W., Kwak, E.L., Hezel, A.F., Miksad, R., Abrams, T.A., Enzinger, P.C., Fuchs, C.S., Ryan, D.P., Jain, R.K. (2009) Efficacy, Safety, and Potential Biomarkers of Sunitinib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study. Journal of Clinical Oncology. Vol. 27(18):3027-3035.
Interleukin, IL6, IL8, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, Vascular endothelial growth factor receptor, Placental growth factor, Basic fibroblast growth factor
Analytes tested using MSD assays: VEGF, PlGF, soluble VEGFR1, bFGF, IL-1beta, IL-6, IL-8, TNF-alpha
Matrix tested: Human EDTA plasma
Summary: This paper discusses the results of a multidisciplinary clinical trial using sunitinib drug to treat hepatocellular carcinoma.
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| Calvo, K.R., Dabir, B., Kovach, A., Devor, C., Bandle, R., Bond, A., Shih, J.H., Jaffe, E.S. (2008) IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma. Blood. Vol. 112(9):3818-26.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha
Matrix tested: Human lymph node cell lysates from follicular lymphoma patients
Summary: In this paper, the cytokine profile in lymph nodes of patients with Follicular Lymphoma was studied to better understand signaling networks associated with tumor.
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| Catalfamo, M., Di Mascio, M., Hu, Z., Srinivasula, S., Thaker, V., Adelsberger, J., Rupert, A., Baseler, M., Tagaya, Y., Roby, G., Rehm, C., Follmann, D., Lane, H.C. (2008) HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells. PNAS. Vol. 105(50):19851-19856.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha
Matrix tested: Human serum
Summary: The mechanism of immune activation and CD4 depletion during HIV infection has been discussed in this paper.
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| de la Rosa, G., Yang, D., Tewary, P., Varadhachary, A., Oppenheim, J.J. (2008) Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses. J Immunol. Vol. 180(10):6868-76.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: Human TH1/TH2 10-Plex (IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-alpha
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: In this paper, the interaction of lactoferrin with cells of the immune system has been investigated in detail.
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| Dennis, A., Kudo, T., Kruidenier, L., Girard, F., Crepin, V.F., MacDonald, T.T., Frankel, G., Wiles, S. (2008) The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium. Infect Immun. Vol. 76(11):4978-88.
Interleukin, IL6, IL10, IL12, IL12-p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, KC / GRO / CINC, tumor necrosis factor, NFkB, Nuclear Factor kappa B
Analytes tested using MSD assays: Mouse ProInflammatory 7-plex (IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC/GRO/CINC, TNF-alpha
Matrix tested: Mouse colon tissue homogenates
Summary: The transcription factor, NF-kB, has been found to be crucial in maintaining intestinal inflammation during host defense, and in this study, the immune response of mice lacking the p50 subunit of NF-kB during C. rodentium infection has been assessed.
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| Dillon, T.M., Ricci, M.S., Vezina, C., Flynn, G.C. Liu, Y. D., Rehder, D.S., Plant, M., Henkle, B., Li, Y., Deechongkit, S., Varnum, B., Wypych, J., Balland, A., Bondarenko P. V. (2008) Structural and functional characterization of disulfide isoforms of the human IGG2 subclass. J Biol Chem. Vol. 283(23):16206-15.
Interleukin, IL6
Analytes tested using MSD assays: Human IL-6
Matrix tested: Human serum
Summary: In this paper, a method has been described to make disulphide forms of human IgG2 antibody and the potency and biophysical properties of these forms have been discussed.
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| Dower, K., Ellis, D.K., Saraf, K, Jelinsky, S.A., Lin, L.L. (2008) Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide. J Immunol. Vol. 180(5):3520-34.
Interleukin, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, IL12p40, IL12-p40, Granulocyte Macrophage Colony Stimulating Factor
Analytes tested using MSD assays: IL-1beta, IL-12p40, GM-CSF
Matrix tested: Cell culture supernatants
Summary: In this paper, the cellular consequences of TREM-1 activation have been investigated by characterizing global gene expression changes in human monocytes in response to TREM-1 cross-linking in comparison to and combined with LPS.
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| Fichorova R.N., Richardson-Harman, N., Alfano, M., Belec, L., Carbonneil, C., Chen, S., Cosentino, L., Curtis, K., Dezzutti, C.S., Donoval, B. Doncel, G.F., Donaghay, M., Grivel, J.C., Guzman, E., Hayes, M., Herold, B, Hillier, S., Lackman-Smith, C., Landay, A., Margolis, L., Mayer, K.H., Pasicznyk, J.M., Pallansch-Cokonis, M., Poli, G., Reichelderfer, P., Roberts, P., Rodriguez, I., Saidi, H., Sassi, R.R., Shattock, R., Cummins, J.E. Jr. (2008) Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study. Anal Chem. Vol. 80(12): 4741-51.
Interleukin, IL6, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: Human IL-1beta, IL-6
Matrix tested: Human serum and surrogate vaginal fluid
Summary: In this paper, different immunoassay formats (microplate vs bead-based) from different companies were evaluated to measure cytokines in complex biological fluids such as surrogate vaginal fluid and human serum. Intra- and Interlaboratory comparisons were done by 12 laboratories in four countries, using 14 immunoassays and four detection platforms based on absorbance, chemiluminescence, electrochemiluminescence, and fluorescence.
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| Fitzgerald, P., Cassidy Eugene, M., Clarke, G., Scully, P., Barry, S., Quigley Eamonn, M.M., Shanahan, F., Cryan, J., Dinan, T. G. (2008) Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity. Neurogastroenterol Motil. Vol. 20(12):1291-7.
Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IFN-gamma
Matrix tested: Human plasma
Summary: This study examined the hypothesis that Irritable bowel syndrome is associated with increased tryptophan (Trp) catabolism along the Kynurenine pathway due to increased IFN-gamma levels.
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| Grund, E.M., Kagan, D., Tran, C.A., Zeitvogel, A., Starzinski-Powitz, A., Nataraja, S., Palmer, S.S. (2008) Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells. Mol Pharmacol. Vol. 73(5):1394-404.
Interleukin, IL6, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IL-6, IL-8, GMCSF, MCP-1, phospho (Thr180/Tyr182) and total p38, phospho (Ser473) and total Akt, phospho NFkB (Ser468), phospho (Thr202/Tyr204) and total Erk
Matrix tested: Cell culture supernatants
Summary: This study explores the ability of TNF-alpha binding protein (TBP) and kinase inhibitors to reduce the inflammatory and necrotic effects of TNF-alpha in relation to endometriosis.
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| Haskova, Z., Hoang, B., Luo, G., Morgan, L.A., Billin, A.N., Barone, F.C., Shearer, B.G., Barton, M.E., Kilgore, K.S. (2008) Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARbeta/delta ligand GW0742. Inflamm Res. Vol. 57(7):314-21.
Interleukin, IL6, IL8, Monocyte Chemotactic Protein, Macrophage-Derived Chemokine, Granulocyte Macrophage Colony Stimulating Factor
Analytes tested using MSD assays: IL-1beta, IL-6, TNF-alpha
Matrix tested: Mouse bronchoalveolar lavage fluid (BALF)
Summary: This study explored the anti-inflammatory effects of PPARß/d activation by use of the selective PPARß/d ligand (GW0742) in a mouse model of lipopolysaccharide (LPS)-induced pulmonary inflammation.
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| Herberich, B., Cao, G.Q., Chakrabarti, .PP., Falsey, J.R., Pettus, L., Rzasa, R.M., Reed, A.B., Reichelt, A., Sham, K., Thaman, M., Wurz, R.P., Xu, S., Zhang, D., Hsieh, F., Lee, M.R., Syed, R., Li, V., Grosfeld, D., Plant, M.H., Henkle, B., Sherman, L., Middleton, S., Wong, L.M., Tasker, A.S. (2008) Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold. J Med Chem. Vol. 51 (20):6271-6279.
Interleukin, IL8, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, quinazoline, SAR
Analytes tested using MSD assays: IL-8, TNF-alpha
Matrix tested: Cell culture supernatant, rat plasma
Summary: In this study, novel phthalazine-based inhibitors of p38 have been generated and their structure-activity relationship has been examined to make orally bioavailable inhibitors with good pharmacokinetic properties for the treatment of inflammatory diseases.
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| Inglefield, J.R., Dumitru, C.D., Alkan, S.S., Gibson, S.J., Lipson, K.E., Tomai, M.A., Larson, C.J., Vasilakos, J.P. (2008) TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN. J Interferon Cytokine Res. Vol. 28(4):253-63.
Interleukin, IL8, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, quinazoline, SAR
Analytes tested using MSD assays: MCP-1, IP-10, IL-12p70
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: The antitumor effects of a TLR7 agonist, 852A, has been evaluated in this paper by measuring the .ability of 852A induced cytokines to block in vitro and in vivo tumor proliferation.
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| Koppelman, B., Webb, H.K., Medicherla, S., Almirez, R., Feng, Y., Chavez, J.C., Mao, C.P., Nguyen, A., Liu, Y.W., Kapoun, A.M., Muiru, G., Huang, Y.A., Dugar, S., Mavunkel, B.J., Lim, D.W., Chakravarty, S., Luedtke, G., Protter, A.A., Higgins, L.S. (2008) Pharmacological properties of SD-282 - an alpha-isoform selective inhibitor for p38 MAP kinase. Pharmacology. Vol. 81(3):204-20.
Interleukin, IL6, IL8, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, p38 MAP kinase, Asthma, sepsis
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, TNF-alpha
Matrix tested: Human plasma
Summary: The focus of this study was to examine the pharmacological properties of SD-282, which displays a very high specificity for inhibiting p38 MAPK, on cytokine production in vitro as well as in vivo.
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| Kwok, W.W., Yang, J., James, E., Bui, J., Huston, L., Wiesen, A.R., Roti, M. (2008) The anthrax vaccine adsorbed vaccine generates protective antigen (PA)-Specific CD4+ T cells with a phenotype distinct from that of naive PA T cells. Infect Immun. Vol. 76(10):4538-45.
Interleukin, IL5, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IFN-gamma, IL-5, IL-13
Matrix tested: Cell culture supernatants
Summary: In this paper, a group of individuals immunized with anthrax vaccine was compared with a group of unvaccinated volunteers to examine the CD4+ T-cell responses against Protective Antigen elicited by vaccination.
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| Lee, J.K., McCoy M.K, Harms, A.S, Ruhn, K.A., Gold S.J., Tansey M.G. (2008) Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response. J Neurosci. Vol. 28(34):8517-28.
Interleukin, IL6, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12, KC / GRO, TNF-alpha
Matrix tested: Mouse microglial BV2 cell culture supernatants
Summary: This paper discusses the regulatory effect of RGS10 (regulator of G-protein signaling 10) on microglial activation and neuron survival in relation to Parkinson's disease.
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| Leng, S.X., McElhaney, J.E., Walston J.D., Xie D.X., Fedarko N.S., Kuchel, G.A. (2008) ELISA and Multiplex Technologies for Cytokine Measurement in Inflammation and Aging Research. J Gerontol A Biol Sci Med Sci. Vol. 63(8):879-84.
MESO SCALE DISCOVERY, Luminex, ELISA, multiplex, aging, inflammation, multiplex arrays
Summary: This paper compares ELISA with different multiplex technologies with respect to technical aspects, cost and methodological issues for the measurement of cytokines in older adults.
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| Li, Y.Y., Bao, M., Meurer, J., Skuballa, W., Bauman, J.G., Doecke, W.D., Zollner, T.M. (2008) The identification of a small molecule inhibitor that specifically reduces T cell-mediated adaptive but not LPS-mediated innate immunity by T cell membrane-monocyte contact bioassay. Immunol Lett. Vol. 117(1):114-8.
384-well assay, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: In this study, the authors developed a T cell-monocyte contact bioassay to identify compounds that block TNF-alpha production from T cell-mediated, but not LPS-mediated, monocyte activation, and will therefore have an improved side-effect profile.
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Lloyd, E., Somera-Molina, K., Van Eldik, L.J., Watterson, D.M., Wainwright, M.S. (2008) Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.
J Neuroinflammation. Vol. 30(5):28.
Interleukin, IL-1beta, IL-1b, IL1ß, IL1b, IL6, TNF-a, TNFa, TNFa, TNF-a, TNFalpha
Analytes tested using MSD assays: IL-1ß, IL-6, TNF-alpha and CCL2
Matrix tested: Brain extracts from mouse model of closed head injury
Summary: This paper tested the hypothesis that regulation of cytokine and chemokine levels following traumatic brain injury causes a decrease in neurologic injury and improves brain function. A small molecule experimental drug called Minozac was used to suppress the up-regulation of cytokines after injury.
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| Luger, D., Silver, P.B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E.P., Sgambellone, N.M., Chan, C.C., Caspi, R.R. (2008) Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. Vol. 205(4):799-810.
Interleukin, IL17
Analytes tested using MSD assays: Customer developed IL-17F assay
Matrix tested: Cell culture supernatants
Summary: In this paper, the role of IL-23 - IL-17 pathway in the pathogenesis of experimental autoimmune uveitis has been examined.
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| Luqman, M., Klabunde, S., Lin, K., Georgakis, G.V., Cherukuri, A., Holash, J., Goldbeck, C., Xu, X., Kadel, E.E. 3rd, Lee, S.H., Aukerman, S.L., Jallal, B., Aziz, N., Weng, W.K., Wierda, W., O'Brien, S., Younes, A. (2008) The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood. Vol. (112)3:711-720.
Interleukin, IL6, IL8, IL10, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, Granulocyte Macrophage Colony Stimulating Factor
Analytes tested using MSD assays: IL-6, IL-8, IL-10, GM-CSF, TNF-alpha
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: This study demonstrates the effect of HCD122, a novel anti-CD40 monoclonal antibody, in inhibiting CD40 ligand-induced activation of signaling pathways, proliferation and survival of B-cell chronic lymphocytic leukemia cells.
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| Mathieu, M.C., Lord-Dufour, S., Bernier, V., Boie, Y., Burch, J.D., Clark, P., Denis, D., Han, Y., Mortimer, J.R., Therien, A.G. (2008) Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis. Eur J Immunol. Vol. 38(7):1900-12.
Interleukin, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, Interferon Inducible Protein 10
Analytes tested using MSD assays: IFN-gamma, IL-12, IP-10
Matrix tested: Human plasma, human fibroblast-like synoviocytes (FLS) cell culture supernatants
Summary: In this paper, the roles of prostaglandin E2 and IFN-gamma in chronic inflammation associated with rheumatoid arthritis has been investigated.
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| McDaniel, J.C., Belury, M., Ahijevych, K., Blakely, W. (2008) Omega-3 fatty acids effect on wound healing. Wound Repair Regen. Vol. 16(3):337-45.
Interleukin, IL6, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IL-1 beta, IL-6, TNF-alpha
Matrix tested: Wound blister fluid
Summary: In this paper, the effects of marine-derived o-3 eicosapentaenoic (EPA) and docosahexaenoic (DHA) polyunsaturated fatty acids on the levels of proinflammatory cytokines in wound fluid and the time to complete healing in healthy, human skin were evaluated.
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| Netterwald, J. (2008) Immuno's Logical - Drug developers turn to the new and established immunoassay platforms to measure and identify protein biomarkers. Drug Disc Devel. Vol. 11(10):24-28.
Interleukin, IL6, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Summary: This is a magazine article that serves as a minireview of newly available immunoassay platforms for the identification of protein biomarkers.
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| Newland, N., Richter, A. (2008) Agents associated with lung inflammation induce similar responses in NCI-H292 lung epithelial cells. Toxicol In Vitro. Vol. 22(7):1782-8.
Interleukin, IL6, IL8
Analytes tested using MSD assays: IL-6, IL-8
Matrix tested: Cell culture supernatant
Summary: In this study, the authors examined the ability of a lung epithelial model to respond to lung toxicants including cigarette smoke total particulate matter, fly ash, bleomycin, lipopolysaccharide, vanadyl sulphate, diesel exhaust particles, and carbon black.
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| Patsouris, D, Li, P.P., Thapar, D., Chapman, J., Olefsky, J.M., Neels, J.G. (2008) Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. Vol. 8(4):301-9.
Interleukin, IL6, IL10, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, Monocyte Chemotactic Protein, Granulocyte Macrophage Colony Stimulating Factor
Analytes tested using MSD assays: Mouse pro-inflammatory 7 plex (IFN-gamma, IL-1beta, IL-6, IL-10, IL-12p70, KC / GRO / CINC, TNF-alpha), Custom Metabolic panel (IL-6, GM-CSF, insulin, MCP-1, resistin, TNF-alpha)
Matrix tested: Mouse serum and tissue lysates
Summary: This study investigates the role of a specific subset of macrophages that express CD11c in the development of obesity-associated insulin resistance and type II diabetes.
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| Roti, M., Yang, J., Berger, D., Huston, L., James, E.A., Kwok, W.W. (2008) Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus. J Immunol. Vol. 180(3):1758-68.
Interleukin, IL5, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-5, IL-13, TNF-alpha
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: This study tested the hypothesis that CD4+ T cells generated in response to other Influenza A viruses can recognize H5N1 viral proteins due to homology between the viral proteins of different influenza A subtypes.
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| Ryan, K.R., Hong, M., Arkwright, P.D., Gennery, A.R., Costigan, C., Dominguez, M., Denning, D., McConnell, V., Cant, A.J., Abinun, M., Spickett, G.P., Lilic, D. (2008) Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED. Clin Exp Immunol. Vol. 154(3):406-14.
Interleukin, IL2, IL5, IL6, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-2, IL-5, IL-6, IL-10, IL-12p70, IL-13, TNF-alpha
Matrix tested: Human monocyte-derived dendritic cell (moDC) culture supernatants
Summary: This study investigated dendritic cell function in response to Candida and non-Candida infections, to assess the underlying mechanisms in the pathogenicity of chronic mucocutaneous candidiasis (CMC).
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| Schneider, C., Docke, W.D., Zollner, T.M., Rose, L. (2008) Chronic Mouse Model of TMA-Induced Contact Hypersensitivity. J Invest Dermatol. Vol. 129(4):899-907.
Interleukin, IL4, IL12, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-4, IL-12, IL-13, TNF-alpha
Matrix tested: Mouse ear homogenates
Summary: In this study a chronic mouse model for atopic dermatitis was developed by comparing a standard acute trimellitic anhydride (TMA)-induced chronic hypersensitivity model in Balb/c mice with subacute and chronic models of TMA-induced ear inflammation.
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| Serra, A., Nuti, S., Tavarini, S., Sammicheli, C., Rosa, D., Saletti, G., Soldaini, E., Abrignani, S., Wack, A. (2008) Coligation of the Hepatitis C Virus Receptor CD81 with CD28 Primes Naive T Lymphocytes to Acquire Type 2 Effector Function. J Immunology. Vol. 181:174-185.
Interleukin, IL2, IL4, IL5, IL10, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-2, IL-4, IL-5, IL-10, TNF-alpha
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: In this study, a novel T-cell receptor independent activation pathway has been described for human T cells based on co-engagement of the costimulatory molecule CD28 and a number of tetraspanins including the HCV receptor CD81.
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| Sun, J., Schiffman, J., Raghunath, A., Ng Tang, D., Chen, H., Sharma, P. (2008) Concurrent decrease in IL-10 with development of immune-related adverse events in a patient treated with anti-CTLA-4 therapy. Cancer Immun. Vol. 8:9.
Interleukin, IL2, IL4, IL10, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g
Analytes tested using MSD assays: IFN-gamma, IL-2, IL-4, IL-10
Matrix tested: Human plasma
Summary: In this paper, immune related adverse events (irAEs) in patients treated with anti-CTLA-4 antibody have been investigated by measuring plasma cytokines in bladder cancer patients treated with anti-CTLA-4 therapy.
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| Thompson, W.L., Karpus W.J., Van Eldik, L.J. (2008) MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult. J Neuroinflam. Vol. 5:35.
Monocyte Chemotactic Protein
Analytes tested using MSD assays: MCP-1
Matrix tested: Mouse brain homogenates
Summary: This study examined the role of the chemokine MCP-1 in activation of the brain during acute systemic inflammation by testing the effects of inhibiting MCP-1 on brain inflammation using MCP-1 knock-out mice.
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| Toedter, G., Hayden, K., Wagner, C., Brodmerkel, C. (2008) Simultaneous Detection of Eight Analytes in Human Serum by Two Commercially Available Platforms for Multiplex Cytokine Analysis. Clin Vaccine Immunol. Vol. 15(1):42-48.
Interleukin, IL4, IL6, IL12p40, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, Monocyte Chemotactic Protein, MIP1ß, MIP1b, MIP1beta, vascular endothelial growth factor, macrophage inflammatory protein
Analytes tested using MSD assays: IFN-gamma, VEGF, IL-4, IL-6, IL-12p40, MIP-1beta, MCP-1, TNF-alpha
Matrix tested: Human serum
Summary: In this study, a comparison of two commercially available multiplex Platforms, MESO SCALE DISCOVERY and Pierce SearchLight technology was done in conjunction with standard ELISA to measure eight different cytokines in serum samples from subjects with ulcerative colitis, Crohn's disease, rheumatoid arthritis (RA), and psoriasis. Spike recovery and the range of quantitation were also compared.
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| Tran, T.A., McCoy, M.K., Sporn, M.B., Tansey, M.G. (2008) The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. J Neuroinflammation. Vol. 5:14.
Interleukin, IL6, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12, KC / GRO / CXCL1, TNF-alpha
Matrix tested: Murine BV2 microglial cell culture supernatants
Summary: This study examined the cellular basis for the anti-inflammatory properties of a synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me), its ability to modulate microglial activity and protect neurons against inflammation.
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| Wolk, K.E., Lazarowski, E.R., Traylor, Z.P., Yu, E.N., Jewell, N.A., Durbin, R.K., Durbin, J.E., Davis, I.C. (2008) Influenza A virus inhibits alveolar fluid clearance in BALB/c mice. Am J Respir Crit Care Med. Vol. 178(9):969-76.
pro-inflammatory
Analytes tested using MSD assays: Proinflammatory cytokines and chemokines (not individually listed)
Matrix tested: Bronchoalveolar lavage fluid from BALB/c mice
Summary: Alveolar fluid clearance after Influenza A viral infection was tested in BALB/c mice.
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| Yang, B., Trump, R.P., Shen, Y., McNulty, J.A., Clifton, L.G., Stimpson, S.A., Lin, P., Pahel, G.L. (2008) RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice. BMC Pharmacology. Vol. 8:7.
Interleukin, IL6, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, IL-10, IL-12, KC / GRO / CXCL1, TNF-alpha
Matrix tested: Murine BV2 microglial cell culture supernatants
Summary: This study is based on the comparison of IL-13 expression in peripheral blood T-cells and eosinophils from asthma patients with healthy controls and attempts to identify an inflammatory stimulus for this expression.
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| Young, H.A. (2008) Cytokine Multiplex Analysis in Inflammation and Cancer. Methods and Protocols: ed. Kozlov, S.V. Volume 1: Experimental Models and Practical Approaches. Vol. 511: 85-105.
RNAse protection assay, high throughput genomics, PCR, MSD, Luminex, SearchLight, FASTQuant, Flow cytometry, FlowCytomix, ELISA
Summary: This article reviews the different commercial approaches that are available for the analysis of multiple cytokines in single samples at the protein and RNA levels.
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| Chen, J.H., Zhang, Z.M. Stebbins J.L., Zhang, X.Y., Hoffman, R., Moore, A., Pellecchia, M. (2007) A Fragment-Based Approach for the Discovery of Isoform-Specific p38 Inhibitors. ACS Chem Bio. Vol. 2(5):329-336.
TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Cell culture medium
Summary: In this paper, a new method for the discovery of novel kinase inhibitors has been developed based on the application of the interligand NOE (nuclear Overhauser effect) fragment-based approach. NMR spectroscopy was used for screening and structure determination.
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| Ghosh, T.K., Michelson, D.J., Solberg, J.C., Lipson, K.E., Inglefield, J.R., Alkan, S.S. (2007) TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha. Int Immunopharmacol. Vol. 7(8):1111-21.
Interleukin, IL12p70, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, IFNalpha, IFN-a, IFNa, IFNa, IFN-a, IFNbeta, IFN-ß, IFNß, IFNb, IFN-b, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor
Analytes tested using MSD assays: IFN-alpha, IFN-beta, IFN-gamma, IL-12p70, TNF-alpha
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: In this study, the effect of a combination of Toll-like receptor agonists on cytokine production was examined using human PBMCs.
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| Hagemann, T., Robinson, S.C., Thompson, R.G., Charles, K., Kulbe, H., Balkwill, F.R. (2007) Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis. Mol Cancer Ther. Vol. 6(7):1993-2002.
Interleukin, IL2, IL4, IL5, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-10, IL-12, KC / GRO / CINC, TNF-alpha
Matrix tested: Ascites fluid from ovarian carcinoma patients, cell culture supernatants
Summary: This paper examined the mechanisms through which malignant cell-derived macrophage migration inhibitory factor (MIF) influences ovarian cancer growth and invasion.
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| Hall, J.P., Kurdi Y., Hsu S., Cuozzo J., Liu J., Telliez J.B., Seidl K.J., Winkler, A., Hu, Y., Green, N., Askew, G.R., Tam, S., Clark, J.D., Lin, L.L. (2007) Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. Vol. 282(46):33295-304.
Interleukin, IL8
Analytes tested using MSD assays: IL-8
Matrix tested: HeLa cell culture supernatants
Summary: In this study, several highly selective and potent small molecule inhibitors of Tpl2 (MAPKKK in the ERK and the Tpl2-MEK-ERK signaling pathways) activity to validate the functions of Tpl2 in human cells.
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| Holland, S.M., DeLeo, F.R., Elloumi, H.Z., Hsu, A.P., Uzel, G., Brodsky, N., Freeman, A.F., Demidowich, A., Davis, J., Turner, M.L., Anderson, V.L., Darnell, D.N., Welch, P.A., Kuhns, D.B., Frucht, D.M., Malech, H.L., Gallin, J.I., Kobayashi, S.D., Whitney, A.R., Voyich, J.M., Musser, J.M., Woellner, C., Schäffer, A.A., Puck, J.M., Grimbacher, B. (2007) STAT3 Mutations in the Hyper-IgE Syndrome. New England J Med. Vol. 357(16):1655-1658.
Interleukin, IL8
Analytes tested using MSD assays: Cytokines (type not specifically mentioned)
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: This study investigated the phenotypes of patients suffering from autosomal dominant hyper-immunoglobulin E syndrome (HIES) to assay gene expression and in vitro cytokine production to identify relevant pathways.
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| Lutterloh, E.C., Opal, S.M., Pittman, D.D., Keith, J.C., Tan, X.Y., Clancy, B.M., Palmer, H., Milarski, K., Sun, Y., Palardy, J.E., Parejo, N.A., Kessimian, N. (2007) Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection. Crit Care. Vol. 11(6):122.
Monocyte chemoattractant protein, Interleukin, IL6, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-6, MCP-1, TNF-alpha
Matrix tested: Mouse serum
Summary: The therapeutic role of RAGE inhibition was examined in the mouse cecal ligation and puncture (CLP) model of polymicrobial sepsis and a mouse model of systemic listeriosis.
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| Patou, J., Gevaert, P., Van Zele, T., Holtappels, G., van Cauwenberge, P., Bachert, C. (2007) Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps. J Allergy Clin Immunol. Vol. 121 (1):110-115.
Interleukin, IL2, IL4, IL5, IL8, IL10, IL12p70, IL13, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, TNF-a
Matrix tested: Human nasal tissue homogenates
Summary: This study investigated the modulatory effects of the S. aureus surface proteins SpA, LTA, and enterotoxin B (SEB) in nasal polyp tissue and tested the differences from normal nasal (control) tissue.
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| Ronkina, N., Kotlyarov, A., Dittrich-Breiholz, O., Kracht, M., Hitti, E., Milarski, K. (2007) The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK. Mol Cell Biol. Vol. 27(1):180-181.
Monocyte chemoattractant protein, Interleukin, IL1, IL6, IL8, IL10, IL12p40, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, Granulocyte Macrophage Colony Stimulating Factor, regulated upon activation, normal T cell expressed and secreted
Analytes tested using MSD assays: IFN-gamma, IL-1, IL-6, IL-8, IL-10, IL-12p40, KC / GRO / CINC, RANTES, GM-CSF, MCP-1, TNF-alpha
Matrix tested: Mouse bone marrow-derived macrophage cell culture supernatants
Summary: MK2 and MK3 are protein kinases downstream of p38 mitogen-activated protein kinase (MAPK). In this paper, the physiological role of MK3 has been analyzed by gene targeting strategy in an MK2-free genetic background.
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| Salter, M., Biggadike, K., Matthews, J.L., West, M.R., Haase, M.V., Farrow, S.N., Uings, I.J, Gray, D.W. (2007) Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease. Am J Physiol Lung Cell Mol Physiol. Vol. 293(3):L660-7.
Tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: This study examined the properties of Fluticasone furoate (FF), a novel enhanced-affinity glucocorticoid for topical therapy for allergic rhinitis, with respect to its efficacy, selectivity, and tissue binding.
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| Seike, M., Yanaihara, N., Bowman, E.D., Zanetti, K.A., Budhu, A., Kumamoto, K., Mechanic, L.E., Matsumoto, S., Yokota, J., Shibata, T., Sugimura, H., Gemma, A., Kudoh, S., Wang, X.W., Harris, C.C. (2007) Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. J Natl Cancer Inst. Vol. 15(99):1257-69.
Interleukin, IL2, IL8, IL10, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: IFN-gamma, IL-1beta, IL-2, IL-8, IL-10, TNF-alpha
Matrix tested: Human lung tissue homogenates
Summary: In this study, gene expression profiling of noncancerous lung tissue was done to test whether it could predict the metastatic capability of lung adenocarcinoma.
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| Sterling T.R., Martire, T., de Almeida, A.S., Ding, L., Greenberg, D.E., Moreira, L.A., Elloumi, H., Torres, A.P., Sant'Anna, C.C., Calazans, E., Paraguassu, G., Gebretsadik, T., Shintani, A., Miller, K., Kritski, A., Lapa e Silva, J.R., Holland, S.M. (2007) Immune function in young children with previous pulmonary or miliary/meningeal tuberculosis and impact of BCG vaccination. Pediatrics. Vol. 120(4):912-21.
Interleukin, IL8
Analytes tested using MSD assays: IL-8
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: This paper investigated the immunologic factors associated with military / meningeal tuberculosis in young children.
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| Thomas, A., Laxton, C., Rodman, J., Myangar, N., Horscroft, N., Parkinson, T. (2007) Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. Antimicrob Agents Chemother. Vol. 51(8):2969-78.
Interleukin, IL6, Interferon, IFNalpha, IFN-a2a, IFNa2a, IFNa2a, IFN-a2a, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor
Analytes tested using MSD assays: IFN-alpha2a, IL-1beta, IL-6, TNF-alpha
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: This paper examined the effects of agonists of Toll-like receptors 1 to 9 to see which ones are capable of inducing antiviral activity against HCV infection in human peripheral blood mononuclear cells (PBMCs).
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| Trifonova, R.T., Bajpai, M., Pasicznyk, J.M., Chandra, N., Doncel, G.F., Fichorova, R.N. (2007) Biomarkers of leukocyte traffic and activation in the vaginal mucosa. Biomarkers. Vol. 12(6):608-22.
vascular adhesion molecule, HIV-1
Analytes tested using MSD assays: E-selectin, VCAM-1
Matrix tested: Human cervicovaginal lavage (CVL) fluid
Summary: This paper is based on the identification of non-invasive soluble biomarkers of vascular and leukocyte activation for the evaluation of compound-induced cervicovaginal mucosal inflammation.
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| Athauda, G., Giubellino, A., Coleman, J.A., Horak, C., Steeg, P.S., Lee, M.J., Trepel, J., Wimberly, J., Sun, J., Coxon, A., Burgess, T.L., Bottaro, D.P. (2006) c-Met Ectodomain Shedding Rate Correlates with Malignant Potential. Clin Cancer Res. Vol. 12(14):4154-4162.
Hepatocyte growth factor receptor, cMet, cancer
Analytes tested using MSD assays: Customer developed assay on MSD Streptavidin plates for ectodomain of c-Met
Matrix tested: Cell culture supernatants
Summary: This study tested the hypothesis that c-Met overexpression in cancer might result in increased ectodomain shedding, which in turn could be a biomarker of tumor progression.
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| Bower, W.A., Culver, D.H., Castor, D., Wu, Y., James, V.N., Zheng, H., Hammer, S., Kuhnert, W.L., Williams, I.T., Bell, B.P., Vlahov, D., Dezzutti, C.S. (2006) Changes in hepatitis C virus (HCV) viral load and interferon-alpha levels in HIV/HCV-coinfected patients treated with highly active antiretroviral therapy. J Acquir Immune Defic Syndr. Vol. 42(3):293-7.
Interferon, IFNalpha, IFN-a, IFNa, IFNa, IFN-a
Analytes tested using MSD assays: IFN-alpha
Matrix tested: Human serum
Summary: In this study, the authors evaluated the impact of Highly Active Antiretroviral Therapy (HAART) on HCV RNA titer and transaminase levels in HIV / HCV-coinfected patients.
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| Fichorova, R.N., Trifonova, R.T., Gilbert, R.O., Costello, C.E., Hayes, G.R., Lucas, J.J., Singh, B.N. (2006) Trichomonas vaginalis Lipophosphoglycan Triggers a Selective Upregulation of Cytokines by Human Female Reproductive Tract Epithelial Cells. Infection and Immunity. Vol. 74(10):5773-5779.
Interleukin, IL6, IL8, IL10, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, MIP3alpha, MIP3a, MIP-3a, MIP-3a, MIP3a, macrophage inflammatory protein 3 alpha
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, IL-10, MIP-3alpha, TNF-alpha
Matrix tested: Cell culture supernatants
Summary: This study tested whether lipophosphoglycan (LPG), the main cell surface glycoconjugate of T. vaginalis, initiates cytokine secretion by host cells.
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| Ge, Y., Montano, I., Rustici, G., Freebern, W.J., Haggerty, C.M., Cui, W., Ponciano-Jackson, D., Chandramouli, G.V., Gardner, E.R., Figg, W.D., Abu-Asab, M., Tsokos, M., Jackson, S.H., Gardner. K. (2006) Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood. Vol. 108:4126-35.
Granulocyte macrophage colony stimulating factor, Interleukin, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, tumor necrosis factor, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß
Analytes tested using MSD assays: GM-CSF, IL1beta, IL2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha
Matrix tested: Cell culture supernatants
Summary: This study is based on the profiling of transcriptional and signal transduction pathways of thalidomide derivatives to identify a novel functional class of thalidomide analogs that act through direct manipulation of the cellular redox state to selectively kill leukemic cells.
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| Ghosh, T.K., Michelson, D.J., Fink, J., Solberg, J.C., Inglefield, J.R., Hook, D., Gupta, S.K., Gibson, S., Alkan, S.S. (2006) Toll-like receptor (TLR) 2-9 agonists-induced cytokines and chemokines: I. Comparison with T cell receptor-induced responses. Cell Immunol. Vol. 243(1):48-57.
Interferon, IFNalpha, IFN-a, IFNa, IFNa, IFN-a, IFNbeta, IFN-ß, IFNß, IFNb, IFN-b, Interleukin, IL2, IL4, IL8, IL10, IL12p40, IL12p70, IL13, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, IL8, Monocyte Chemotactic Protein, macrophage inflammatory protein 1 beta, MIP1ß, MIP1b, MIP1beta
Analytes tested using MSD assays: IFN-alpha, IFN-beta, IFN-gamma, IL-1beta, IL-2, IL-4, IL-8, IL-10, IL-12p40, IL-12p70, IL-13, TNF-alpha, MCP-1, MIP-1beta, RANTES
Matrix tested: Human peripheral blood mononuclear cell (PBMC) culture supernatants
Summary: In this study, the cytokine and chemokine profiles generated by individual TLR agonists, TLR-TLR and TLR-T cell receptor (TCR) interactions were investigated.
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| Pulichino, A.M., Rowland, S., Wu, T., Clark, P., Xu, D., Mathieu, M.C., Riendeau, D., Audoly, L.P. (2006) Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis. J Pharmacol Exp Ther. Vol. 319(3):1043-50.
Tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Rat whole blood
Summary: In this paper, the role of Prostaglandin type, PGI2, has been examined in a rat model of osteoarthritis (OA) and rheumatoid arthritis using an antagonist to PGI2 receptor an mice that are deficient of this receptor.
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| Ryan, S., Taylor, C.T., McNicholas, W.T. (2006) Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome. Am J Res and Crit Care Med. Vol. 174(7):824-30.
Interleukin, IL1, IL6, IL8, IL10, IL12, Interferon, IFNgamma, IFN-g, IFNg, IFNg, IFN-g, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a
Analytes tested using MSD assays: IFN-gamma, IL-1, IL-6, IL-8, IL-10, IL-12, TNF-alpha
Matrix tested: Human serum
Summary: The focus of this study was to determine, with a particular emphasis on TNF-alpha, the clinical predictors of elevated proinflammatory cytokines in obstructive sleep apnea syndrome (OSAS).
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| Trifonova, R.T., Pasicznyk, J.M., Fichorova, R.N. (2006) Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivo. Antimicrobial Agents and Chemotherapy. Vol. 50(12):4005-10.
Interleukin, IL6, IL8, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, Interferon Inducible Protein 10
Analytes tested using MSD assays: IL-1beta, IL-6, IL-8, IP-10, TNF-alpha
Matrix tested: Human serum
Summary: In this study, a topical anti-HIV-1 microbicide, cellulose acetate 1,2-benzenedicarboxylate (CAP) and other over-the-counter (OTC) vaginal products were evaluated for their impact on inflammatory mediators signifying potential HIV-1-enhancing risk factors.
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| Freebern, W.J., Haggerty, C.M., Montano, I., McNutt, M.C., Collins, I., Graham, A., Chandramouli, G.V.R., Stewart, D.H., Biebuyck, H.A., Taub, D.D., Gardner, K. (2005) Pharmacologic profiling of transcriptional targets deciphers promoter logic. Pharmacogenomics J. Vol. 5(5):305-323.
Granulocyte macrophage colony stimulating factor, Interleukin, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, IL-1b, IL1beta, IL1b, IL-1ß, IL1ß, tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a
Analytes tested using MSD assays: GM-CSF, IL-1beta, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, TNF-alpha
Matrix tested: Cell culture supernatants
Summary: In this study, a novel transcriptional approach for profiling the activation of multiple transcriptional targets against arrays of therapeutic and signal transducing agents has been described.
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| Han, S., Zhou, V., Pan, S., Liu, Y., Hornsby, M., McMullan, D., Klock, H.E., Haugen, J., Lesley, S.A., Gray, N., Caldwell, J., Gu, X.J. (2005) Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett. Vol. 15(24):5467-73.
Tumor necrosis factor, TNFa, TNF-a, TNFalpha, TNFa, TNF-a, ERK, MAPK
Analytes tested using MSD assays: TNF-alpha
Matrix tested: Cell culture supernatants
Summary: This paper is based on the identification of novel inhibitors of the ERK/MAPK pathway using a TR-FRET-based in vitro coupling assay.
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* Pub Med (www.pubmed.gov) is a service of the U.S. National Library of Medicine and the National Institutes of Health
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